27,291 research outputs found
Erythrocyte as a link between basic and clinical research
© 2011 – IOS Press and the authorsWe review the major hemorheological experimental studies that show the erythrocyte aggregation as a link between basic and clinical research. The results of the clinical cross-sectional and longitudinal studies presented here will highlight the possible association between erythrocyte aggregation and plasma fibrinogen. Basic studies conducted in vitro are also mentioned as for its relevance in answering questions raised in clinical settings, as well as and in understanding the underlying influent factors in the erythrocyte tendency to aggregate and disaggregate.This work was supported by
“Fundação para a Ciência e Tecnologia
Some Implications of the Cosmological Constant to Fundamental Physics
In the presence of a cosmological constant, ordinary Poincare' special
relativity is no longer valid and must be replaced by a de Sitter special
relativity, in which Minkowski space is replaced by a de Sitter spacetime. In
consequence, the ordinary notions of energy and momentum change, and will
satisfy a different kinematic relation. Such a theory is a different kind of a
doubly special relativity. Since the only difference between the Poincare' and
the de Sitter groups is the replacement of translations by certain linear
combinations of translations and proper conformal transformations, the net
result of this change is ultimately the breakdown of ordinary translational
invariance. From the experimental point of view, therefore, a de Sitter special
relativity might be probed by looking for possible violations of translational
invariance. If we assume the existence of a connection between the energy scale
of an experiment and the local value of the cosmological constant, there would
be changes in the kinematics of massive particles which could hopefully be
detected in high-energy experiments. Furthermore, due to the presence of a
horizon, the usual causal structure of spacetime would be significantly
modified at the Planck scale.Comment: 15 pages, lecture presented at the "XIIth Brazilian School of
Cosmology and Gravitation", Mangaratiba, Rio de Janeiro, September 10-23,
200
Cosmological Term and Fundamental Physics
A nonvanishing cosmological term in Einstein's equations implies a
nonvanishing spacetime curvature even in absence of any kind of matter. It
would, in consequence, affect many of the underlying kinematic tenets of
physical theory. The usual commutative spacetime translations of the Poincare'
group would be replaced by the mixed conformal translations of the de Sitter
group, leading to obvious alterations in elementary concepts such as time,
energy and momentum. Although negligible at small scales, such modifications
may come to have important consequences both in the large and for the
inflationary picture of the early Universe. A qualitative discussion is
presented which suggests deep changes in Hamiltonian, Quantum and Statistical
Mechanics. In the primeval universe as described by the standard cosmological
model, in particular, the equations of state of the matter sources could be
quite different from those usually introduced.Comment: RevTeX, 4 pages. Selected for Honorable Mention in the Annual Essay
Competition of the Gravity Research Foundation for the year 200
Evidence that the degree of band 3 phosphorylation modulates human erythrocytes nitric oxide efflux – in vitro model of hyperfibrinogenemia
© 2011 – IOS Press and the authors. All rights reservedRecent evidence has shown that plasma fibrinogen, a major cardiovascular risk factor, interacts with the erythrocyte membrane and acts to influence blood flow via erythrocyte nitric oxide (NO) modulation. In the present pioneer in-vitro study, whole blood samples were harvested from healthy subjects and aliquots were incubated in the absence (control aliquots) and presence of fibrinogen at different degrees of band 3 phosphorylation, and the levels of NO, nitrite, nitrate and S-nitroglutathione (GSNO) were determined.
Hyperfibrinogenemia interferes with erythrocyte NO mobilization without changing its efflux in a way that seems to be dependent of the degree of band 3 phosphorylation. In presence of higher fibrinogen concentrations the NO efflux is reinforced when band 3 is phosphorylated (p < 0.001). Higher levels of nitrite, nitrate and GSNO were documented (p < 0.05). However, the mechanisms by which fibrinogen signalling modulates erythrocyte function remain to be clarified and are currently under study. These conditions may be considered an approach to be followed in blood storage for transfusions.This study was supported by grants from the FCT - Fundação para a Ciência e a Tecnologia (project reference PTDC/SAU-OSM/73449/2006
Theoretical investigation of moir\'e patterns in quantum images
Moir\'e patterns are produced when two periodic structures with different
spatial frequencies are superposed. The transmission of the resulting structure
gives rise to spatial beatings which are called moir\'e fringes. In classical
optics, the interest in moir\'e fringes comes from the fact that the spatial
beating given by the frequency difference gives information about details(high
spatial frequency) of a given spatial structure. We show that moir\'e fringes
can also arise in the spatial distribution of the coincidence count rate of
twin photons from the parametric down-conversion, when spatial structures with
different frequencies are placed in the path of each one of the twin beams. In
other words,we demonstrate how moir\'e fringes can arise from quantum images
Quantization of multidimensional cat maps
In this work we study cat maps with many degrees of freedom. Classical cat
maps are classified using the Cayley parametrization of symplectic matrices and
the closely associated center and chord generating functions. Particular
attention is dedicated to loxodromic behavior, which is a new feature of
two-dimensional maps. The maps are then quantized using a recently developed
Weyl representation on the torus and the general condition on the Floquet
angles is derived for a particular map to be quantizable. The semiclassical
approximation is exact, regardless of the dimensionality or of the nature of
the fixed points.Comment: 33 pages, latex, 6 figures, Submitted to Nonlinearit
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