Production trend identification and forecast for shop-floor business intelligence

The paper introduces a methodology to define production trend classes and also the results to serve with trend prognosis in a given manufacturing situation. The prognosis is valid for one, selected production measure (e.g. a quality dimension of one product, like diameters, angles, surface roughness, pressure, basis position, etc.) but the applied model takes into account the past values of many other, related production data collected typically on the shop-floor, too. Consequently, it is useful in batch or (customized) mass production environments. The proposed solution is applicable to realize production control inside the tolerance limits to proactively avoid the production process going outside from the given upper and lower tolerance limits. The solution was developed and validated on real data collected on the shop-floor; the paper also summarizes the validated application results of the proposed methodology. © 2016, IMEKO-International Measurement Federation Secretariat. All rights reserved

Direct, biomimetic synthesis of (+)-artemone via a stereoselective, organocatalytic cyclization

We present a four-step synthesis of (+)-artemone from (–)- linalool, featuring iminium organocatalysis of a doubly diastereoselective conjugate addition reaction. The strategy follows a proposed biosynthetic pathway, rapidly generates stereochemical complexity, uses no protecting groups, and minimizes redox manipulations

IL-2 Immunotherapy to Recently HIV-1 Infected Adults Maintains the Numbers of IL-17 Expressing CD4+ T (TH17) Cells in the Periphery

Little is known about the manipulation of IL-17 producing CD4+ T cells (TH17) on a per-cell basis in humans in vivo. Previous studies on the effects of IL-2 on IL-17 secretion in non-HIV models have shown divergent results. We hypothesized that IL-2 would mediate changes in IL-17 levels among recently HIV-1-infected adults receiving anti-retroviral therapy. We measured cytokine T cell responses to CD3/CD28, HIV-1 Gag, and CMV pp65 stimulation, and changes in multiple CD4+ T cell subsets. Those who received IL-2 showed a robust expansion of naive and total CD4+ T cell counts and T-reg counts. However, after IL-2 treatment, the frequency of TH17 cells declined, while counts of TH17 cells did not change due to an expansion of the CD4+ naïve T cell population (CD27+CD45RA+). Counts of HIV-1 Gag-specific T cells declined modestly, but CMV pp65 and CD3/CD28 stimulated populations did not change. Hence, in contrast with recent studies, our results suggest IL-2 is not a potent in vivo regulator of TH17 cell populations in HIV-1 disease. However, IL-2-mediated T-reg expansions may selectively reduce responses to certain antigen-specific populations, such as HIV-1 Gag

Improvement of product design process by knowledge value analysis

Nowadays, design activities remain the core issue for global product development. As knowledge is more and more integrated, effective analysis of knowledge value becomes very useful for the improvement of product design processes. This paper aims at proposing a framework of knowledge value analysis in the context of product design process. By theoretical analysis and case study, the paper illustrates how knowledge value can be calculated and how the results can help the improvement of product design process, such as deciding which knowledge to choose and what to do next

Sharing meaning and physical activity through a tangible interactive lighting object

This paper searches to explore the relation between designing for interaction and designing for systems by building an interactive lighting object as a part of a system for sharing meaning. The reflective transformative design process with extensive user involvement resulted in creation of an interactive lamp that expresses human-inspired behaviours that can be shared with another lighting object. Different from existing studies, the sharing of meaning was explored in the interaction between the human and the product instead of merely by observation. The preliminary tests showed that shared meaning through interactive lighting behaviours were difficult to interpret to be similar on cognitive (perceptual) level. On the level of experience the object promoted shared aesthetically pleasing responses and was intriguing for users to explore and create shared valu

Preparation and Characterization of Biocompatible Electrospun Nanofiber Scaffolds

Nanoscale fibers were prepared for the fabrication of scaffolds by using a strong electrostatic field on the polymer solution. Electrospinning is widely applied for production of drug delivery, tissue engineering, and regenerative medicine systems as well as biosensors and enzyme immobilization. Nanofibers, thanks to their high surface area to volume ratio, can also mimic the extracellular matrix, thus it has been recognized as a suitable technique for the fast fabrication of scaffolds. This article demonstrates the fabrication of several nanofibrous scaffolds from biopolymers such as polycaprolactone, poly(lactic acid), poly(lactide-co-glycolide), poly(lactide-co-caprolactone) and poly(hydroxybutyrate-co-hydroxy valerate). The characterization and comparison of the scaffolds were achieved based on the morphology and surface characteristic of the nanofibers. The samples showed hydrophobic characteristic, thus a plasma surface treatment was applied successfully to increase hydrophilicity and the effect of the treatment was evaluated based on the wettability and the change in elemental composition of the surface based on X-ray photoelectron spectroscopy