Comments on the superluminal motion in Cygnus X-3

Following the recent discovery that Cyg X-3 exhibits superluminal motion, the implications of superluminal expansion and contraction are investigated. We propose that the effect is due to either a propagating photon pattern or to outwardly moving shells illuminated by an intense beam of radiation.Comment: accepted for publication in MNRAS; 5 pages, 3 figure

Successful paediatric HIV treatment in rural primary care in Africa

<p>Objective: Clinical outcomes of HIV-infected children on antiretroviral treatment (ART) in a decentralised, nurse/counsellor-led programme.</p> <p>Design: Clinical cohort.</p> <p>Setting: KwaZulu-Natal, South Africa.</p> <p>Patients: HIV-infected children aged <= 15 years on ART, June 2004-2008.</p> <p>Main outcome measures: Survival according to baseline characteristics including age, WHO clinical stage, haemoglobin and CD4%, was assessed in Kaplan-Meier analyses. Hazard ratios for mortality were estimated using Cox proportional hazards regression and changes in laboratory parameters and weight-for-age z scores after 6-12 months' treatment were calculated.</p> <p>Results: 477 HIV-infected children began ART at a median age of 74 months (range 4-180), median CD4 count (CD4%) of 433 cells/mm(3) (17%) and median HIV viral load of log 4.2 copies/ml; 105 (22%) were on treatment for tuberculosis and 317 (76.6%) were WHO stage 3/4. There were significant increases after ART initiation in CD4% (17% vs 22%; p<0.001), haemoglobin (9.9 vs 11.7 g/l; p <= 0.001) and albumin (30 vs 36 g/l; p <= 0.001). 32 (6.7%) children died over 732 child-years of follow-up (43.7 deaths/1000 child-years; 95% CI 32.7 to 58.2), 17 (53.1%) within 90 days of treatment initiation; median age of death was 84 (IQR 10-181) months. Children with baseline haemoglobin <= 8 g/l were more likely to die (adjusted HR 4.5; 95% CI 1.6 to 12.3), as were those aged <18 months compared with >60 months (adjusted HR 3.2; 95% CI 1.2 to 9.1).</p> <p>Conclusions Good clinical outcomes in HIV-infected children on ART are possible in a rural, decentralised service. Few young children are on ART, highlighting the urgent need to identify HIV-exposed infants.</p&gt

Simple computer method provides contours for radiological images

Computer is provided with information concerning boundaries in total image. Gradient of each point in digitized image is calculated with aid of threshold technique; then there is invoked set of algorithms designed to reduce number of gradient elements and to retain only major ones for definition of contour

Persistence of Manifolds in Nonequilibrium Critical Dynamics

We study the persistence P(t) of the magnetization of a d' dimensional manifold (i.e., the probability that the manifold magnetization does not flip up to time t, starting from a random initial condition) in a d-dimensional spin system at its critical point. We show analytically that there are three distinct late time decay forms for P(t) : exponential, stretched exponential and power law, depending on a single parameter \zeta=(D-2+\eta)/z where D=d-d' and \eta, z are standard critical exponents. In particular, our theory predicts that the persistence of a line magnetization decays as a power law in the d=2 Ising model at its critical point. For the d=3 critical Ising model, the persistence of the plane magnetization decays as a power law, while that of a line magnetization decays as a stretched exponential. Numerical results are consistent with these analytical predictions.Comment: 4 pages revtex, 1 eps figure include

Exact numerical simulation of power-law noises

Many simulations of stochastic processes require colored noises: I describe here an exact numerical method to simulate power-law noises: the method can be extended to more general colored noises, and is exact for all time steps, even when they are unevenly spaced (as may often happen for astronomical data, see e.g. N. R. Lomb, Astrophys. Space Sci. {\bf 39}, 447 (1976)). The algorithm has a well-behaved computational complexity, it produces a nearly perfect Gaussian noise, and its computational efficiency depends on the required degree of noise Gaussianity.Comment: 14 postscript figures, accepted for publication on Phys. Rev.

Structural phase transitions of vortex matter in an optical lattice

We consider the vortex structure of a rapidly rotating trapped atomic Bose-Einstein condensate in the presence of a co-rotating periodic optical lattice potential. We observe a rich variety of structural phases which reflect the interplay of the vortex-vortex and vortex-lattice interactions. The lattice structure is very sensitive to the ratio of vortices to pinning sites and we observe structural phase transitions and domain formation as this ratio is varied.Comment: 4 pages, 3 figure

Variation of practice and poor outcomes for extremely low gestation births: ordained before birth?

Editorial\uc9ditorialPeer reviewed: YesNRC publication: Ye

Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro

The potent novel poly(ADP-ribose) polymerase (PARP) inhibitor, NU1025, enhances the cytotoxicity of DNA-methylating agents and ionizing radiation by inhibiting DNA repair. We report here an investigation of the role of PARP in the cellular responses to inhibitors of topoisomerase I and II using NU1025. The cytotoxicity of the topoisomerase I inhibitor, camptothecin, was increased 2.6-fold in L1210 cells by co-incubation with NU1025. Camptothecin-induced DNA strand breaks were also increased 2.5-fold by NU1025 and exposure to camptothecin-activated PARP. In contrast, NU1025 did not increase the DNA strand breakage or cytotoxicity caused by the topoisomerase II inhibitor etoposide. Exposure to etoposide did not activate PARP even at concentrations that caused significant levels of apoptosis. Taken together, these data suggest that potentiation of camptothecin cytotoxicity by NU1025 is a direct result of increased DNA strand breakage, and that activation of PARP by camptothecin-induced DNA damage contributes to its repair and consequently cell survival. However, in L1210 cells at least, it would appear that PARP is not involved in the cellular response to etoposide-mediated DNA damage. On the basis of these data, PARP inhibitors may be potentially useful in combination with topoisomerase I inhibitor anticancer chemotherapy. © 2001 Cancer Research Campaign http://www.bjcancer.co