Shubnikov-de Haas oscillations in YBa_2Cu_4O_8

We report the observation of Shubnikov-de Haas oscillations in the underdoped cuprate superconductor YBa$_2$Cu$_4$O$_8$ (Y124). For field aligned along the c-axis, the frequency of the oscillations is $660\pm 30$ T, which corresponds to $\sim 2.4$ % of the total area of the first Brillouin zone. The effective mass of the quasiparticles on this orbit is measured to be $2.7\pm0.3$ times the free electron mass. Both the frequency and mass are comparable to those recently observed for ortho-II YBa$_2$Cu$_3$O$_{6.5}$ (Y123-II). We show that although small Fermi surface pockets may be expected from band structure calculations in Y123-II, no such pockets are predicted for Y124. Our results therefore imply that these small pockets are a generic feature of the copper oxide plane in underdoped cuprates.Comment: v2: Version of paper accepted for publication in Physical Review Letters. Only minor changes to the text and reference

Ekpyrotic collapse with multiple fields

A scale invariant spectrum of isocurvature perturbations is generated during collapse in the scaling solution in models where two or more fields have steep negative exponential potentials. The scale invariance of the spectrum is realised by a tachyonic instability in the isocurvature field. We show that this instability is due to the fact that the scaling solution is a saddle point in the phase space. The late time attractor is identified with a single field dominated ekpyrotic collapse in which a steep blue spectrum for isocurvature perturbations is found. Although quantum fluctuations do not necessarily to disrupt the classical solution, an additional preceding stage is required to establish classical homogeneity.Comment: 13 pages, 1 figur

Evaluation of a thrice weekly administration of teicoplanin in the outpatient setting; retrospective observational multi-centre study

Introduction: The glycopeptide teicoplanin is commonly utilised to facilitate Outpatient Parenteral Antimicrobial Therapy (OPAT). Licensed for once daily maintenance dosing, teicoplanin’s long half-life allows for less frequent dosing (e.g. thrice weekly) following successful loading. This service evaluation reviews the safety and effectiveness of a novel thrice weekly teicoplanin dosing regimen. Methods A retrospective, observational study was conducted at Chelsea & Westminster hospital (March 2018 – July 2020), evaluating trough serum teicoplanin concentrations for patients receiving >5 days of teicoplanin in the OPAT setting. Teicoplanin dosing and administration (once daily versus thrice weekly), clinical outcomes, and therapeutic levels were analysed for all patients. The project was registered with clinical governance locally. Results A total of 82 patients treated with teicoplanin in the OPAT service where included; 53/82 receiving thrice weekly and 29/82 receiving once daily dosing. Mean teicoplanin trough levels were similar in both groups (26.2mg/L and 25.8mg/L in once daily and thrice weekly groups, p=0.8895). High clinical success rates were recorded in both groups (25/29 [86.2%] versus 50/53 [94.3%]). No correlation with clinical outcomes and initial teicoplanin serum levels was identified. Normal renal function (>90mL/min) was associated with lower teicoplanin serum concentrations (21.4mg/L[±10.1] versus 29.7mg/L[SD±14], p = 0.0178) in the thrice weekly dosed group but not with the once daily dosed group (mean 28.2mg/L[±9.4] versus 23.7mg/L[±9.9], p = 0.2201). Conclusions This study supports thrice weekly teicoplanin as a convenient and effective OPAT for administration in the OPAT setting. Therapeutic drug monitoring is advised to adjust for intra-patient variability

Fragile three-dimensionality in the quasi-one-dimensional cuprate PrBa_2Cu_4O_8

In this article we report on the experimental realization of dimensional crossover phenomena in the chain compound PrBa$_2$Cu$_4$O$_8$ using temperature, high magnetic fields and disorder as independent tuning parameters. In purer crystals of PrBa$_2$Cu$_4$O$_8$, a highly anisotropic three-dimensional Fermi-liquid state develops at low temperatures. This metallic state is extremely susceptible to disorder however and localization rapidly sets in. We show, through quantitative comparison of the relevant energy scales, that this metal/insulator crossover occurs precisely when the scattering rate within the chain exceeds the interchain hopping rate(s), i.e. once carriers become confined to a single conducting element.Comment: 12 pages, 5 figures, published at http://www.iop.org/EJ/article/1367-2630/8/9/172/njp6_9_172.htm

Cosmology as Geodesic Motion

For gravity coupled to N scalar fields with arbitrary potential V, it is shown that all flat (homogeneous and isotropic) cosmologies correspond to geodesics in an (N+1)-dimensional `augmented' target space of Lorentzian signature (1,N), timelike if V>0, null if V=0 and spacelike if V<0. Accelerating cosmologies correspond to timelike geodesics that lie within an `acceleration subcone' of the `lightcone'. Non-flat (k=-1,+1) cosmologies are shown to evolve as projections of geodesic motion in a space of dimension (N+2), of signature (1,N+1) for k=-1 and signature (2,N) for k=+1. This formalism is illustrated by cosmological solutions of models with an exponential potential, which are comprehensively analysed; the late-time behviour for other potentials of current interest is deduced by comparison.Comment: 26 pages, 2 figures, journal version with additional reference

Curvature perturbations from ekpyrotic collapse with multiple fields

A scale-invariant spectrum of isocurvature perturbations is generated during collapse in the ekpyrotic scaling solution in models where multiple fields have steep negative exponential potentials. The scale invariance of the spectrum is realized by a tachyonic instability in the isocurvature field. This instability drives the scaling solution to the late time attractor that is the old ekpyrotic collapse dominated by a single field. We show that the transition from the scaling solution to the single field dominated ekpyrotic collapse automatically converts the initial isocurvature perturbations about the scaling solution to comoving curvature perturbations about the late-time attractor. The final amplitude of the comoving curvature perturbation is determined by the Hubble scale at the transition.Comment: 15 pages, 3 figures, a reference added, to be published in CQG, a remark on the comoving density perturbation correcte

Spatial partitioning of the regulatory landscape of the X-inactivation centre

In eukaryotes transcriptional regulation often involves multiple long-range elements and is influenced by the genomic environment. A prime example of this concerns the mouse X-inactivation centre (Xic), which orchestrates the initiation of X-chromosome inactivation (XCI) by controlling the expression of the non-protein-coding Xist transcript. The extent of Xic sequences required for the proper regulation of Xist remains unknown. Here we use chromosome conformation capture carbon-copy (5C) and super-resolution microscopy to analyse the spatial organization of a 4.5-megabases (Mb) region including Xist. We discover a series of discrete 200-kilobase to 1 Mb topologically associating domains (TADs), present both before and after cell differentiation and on the active and inactive X. TADs align with, but do not rely on, several domain-wide features of the epigenome, such as H3K27me3 or H3K9me2 blocks and lamina-associated domains. TADs also align with coordinately regulated gene clusters. Disruption of a TAD boundary causes ectopic chromosomal contacts and long-range transcriptional misregulation. The Xist/Tsix sense/antisense unit illustrates how TADs enable the spatial segregation of oppositely regulated chromosomal neighbourhoods, with the respective promoters of Xist and Tsix lying in adjacent TADs, each containing their known positive regulators. We identify a novel distal regulatory region of Tsix within its TAD, which produces a long intervening RNA, Linx. In addition to uncovering a new principle of cis-regulatory architecture of mammalian chromosomes, our study sets the stage for the full genetic dissection of the X-inactivation centre

Cosmology with positive and negative exponential potentials

We present a phase-plane analysis of cosmologies containing a scalar field $\phi$ with an exponential potential $V \propto \exp(-\lambda \kappa \phi)$ where $\kappa^2 = 8\pi G$ and $V$ may be positive or negative. We show that power-law kinetic-potential scaling solutions only exist for sufficiently flat ($\lambda^26$) negative potentials. The latter correspond to a class of ever-expanding cosmologies with negative potential. However we show that these expanding solutions with a negative potential are to unstable in the presence of ordinary matter, spatial curvature or anisotropic shear, and generic solutions always recollapse to a singularity. Power-law kinetic-potential scaling solutions are the late-time attractor in a collapsing universe for steep negative potentials (the ekpyrotic scenario) and stable against matter, curvature or shear perturbations. Otherwise kinetic-dominated solutions are the attractor during collapse (the pre big bang scenario) and are only marginally stable with respect to anisotropic shear.Comment: 8 pages, latex with revtex, 9 figure

The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network

During early development of female mouse embryos, both X chromosomes are transiently active. X gene dosage is then equalized between the sexes through the process of X chromosome inactivation (XCI). Whether the double dose of X-linked genes in females compared with males leads to sex-specific developmental differences has remained unclear. Using embryonic stem cells with distinct sex chromosome compositions as a model system, we show that two X chromosomes stabilize the naive pluripotent state by inhibiting MAPK and Gsk3 signaling and stimulating the Akt pathway. Since MAPK signaling is required to exit the pluripotent state, differentiation is paused in female cells as long as both X chromosomes are active. By preventing XCI or triggering it precociously, we demonstrate that this differentiation block is released once XX cells have undergone X inactivation. We propose that double X dosage interferes with differentiation, thus ensuring a tight coupling between X chromosome dosage compensation and development

An intercomparison of CH3O2 measurements by Fluorescence Assay by Gas Expansion and Cavity Ring–Down Spectroscopy within HIRAC (Highly Instrumented Reactor for Atmospheric Chemistry)

Simultaneous measurements of CH3O2 radical concentrations have been performed using two different methods in the Leeds HIRAC (Highly Instrumented Reactor for Atmospheric Chemistry) chamber at 295 K and in 80 mbar of a mixture of 3 : 1 He : O2 and 100 mbar or 1000 mbar of synthetic air. The first detection method consisted of the indirect detection of CH3O2 using the conversion of CH3O2 into CH3O by excess NO with subsequent detection of CH3O by fluorescence assay by gas expansion (FAGE). The FAGE instrument was calibrated for CH3O2 in two ways. In the first method, a known concentration of CH3O2 was generated using the 185 nm photolysis of water vapour in synthetic air at atmospheric pressure followed by the conversion of the generated OH radicals to CH3O2 by reaction with CH4 / O2. This calibration can be used for experiments performed in HIRAC at 1000 mbar in air. In the second method, calibration was achieved by generating a near steady-state of CH3O2 and then switching off the photolysis lamps within HIRAC and monitoring the subsequent decay of CH3O2 which was controlled via its self-reaction, and analysing the decay using second order kinetics. This calibration could be used for experiments performed at all pressures. In the second detection method, CH3O2 has been measured directly using Cavity Ring-Down Spectroscopy (CRDS) using the absorption at 7487.98 cm-1 in the A <– X (ν12) band with the optical path along the ~1.4 m chamber diameter. Analysis of the second-order kinetic decays of CH3O2 by self-reaction monitored by CRDS has been used for the determination of the CH3O2 absorption cross section at 7487.98 cm-1, both at 100 mbar of air and at 80 mbar of a 3 : 1 He : O2 mixture, from which σCH3O2 = (1.49 ± 0.19) × 10–20 cm2 molecule-1 was determined for both pressures. The absorption spectrum of CH3O2 between 7486 and 7491 cm-1 did not change shape when the total pressure was increased to 1000 mbar, from which we determined that σCH3O2 is independent of pressure over the pressure range 100–1000 mbar in air. CH3O2 was generated in HIRAC using either the photolysis of Cl2 with UV black lamps in the presence of CH4 and O2 or the photolysis of acetone at 254 nm in the presence of O2. At 1000 mbar of synthetic air the correlation plot of [CH3O2]FAGE against [CH3O2]CRDS gave a gradient of 1.10 ± 0.02. At 100 mbar of synthetic air the gradient of the FAGE – CRDS correlation plot had a gradient of 1.06 ± 0.01 and at 80 mbar of 3 : 1 He : O2 mixture the correlation plot gradient was 0.91 ± 0.02. These results provide a validation of the FAGE method to determine concentrations of CH3O2