El concepto de Praelatus desde los orígenes hasta la Alta Edad Media

Pretendemos con el presente trabajo publicar un extracto de la tesis doctoral presentada en la Facultad de Teología de la Universidad de Navarra en 1988, con el título «El concepto de praelatus desde los orígenes hasta la Alta Edad Media». Consideramos que es un extracto de la entera tesis doctoral puesto que de los siete capítulos de que consta, hemos prescindido solamente del relativo a las Fuentes Epigráficas, por confirmar cuanto hemos obtenido de los testimonios documentales. El objeto de esta investigación es estudiar la evolución del concepto de praelatus desde sus orígenes hasta la Alta Edad Media; es decir, desde que se encuentran los primeros testimonios del uso de dicho término hasta el siglo X. El desarrollo del contenido de praelatus está muy relacionado con la evolución experimentada por las palabras antistes y praesul, que culmina con la asunción por parte del derivado de praelatus en las lenguas romances, del significado bajolatino de los mencionados términos

Combined Treatment with Open and Endovascular Surgery of a Mycotic Abdominal Aortic Aneurysm

AbstractWe report the treatment of a 67-year-old male patient with a suprarenal mycotic aortic aneurysm. A 67-year-old male developed renal failure during the treatment of a urine infection and a paracervical abscess. Further investigations revealed a 5.6cm saccular suprarenal abdominal aortic aneurysm. A successful combined treatment was carried out with endovascular techniques and open surgery, realizing a retrograde aorto-superior mesenteric bypass. Postoperative follow up scans showed exclusion and thrombosis of the aneurysm. Treatment of mycotic aneurysms is mainly surgical, but endovascular therapy helps to avoid highly complicated surgery and reduces mortality

Right Structural and Functional Reorganization in Four-Year-Old Children with Perinatal Arterial Ischemic Stroke Predict Language Production

Brain imaging methods have contributed to shed light on the mechanisms of recovery after early brain insult. The assumption that the unaffected right hemisphere can take over language functions after left perinatal stroke is still under debate. Here, we report how patterns of brain structural and functional reorganization were associated with language outcomes in a group of 4-year-old children with left perinatal arterial ischemic stroke. Specifically, we gathered specific fine-grained developmental measures of receptive and productive aspects of language as well as standardized measures of cognitive development. We also collected structural neuroimaging data as well as functional activations during a passive listening story-telling fMRI task and a resting state session (rs-fMRI). Children with a left perinatal stroke showed larger lateralization indices of both structural and functional connectivity of the dorsal language pathway towards the right hemisphere that, in turn, were associated with better language outcomes. Importantly, the pattern of structural asymmetry was significantly more right-lateralized in children with a left perinatal brain insult than in a group of matched healthy controls. These results strongly suggest that early lesions of the left dorsal pathway and the associated perisylvian regions can induce the inter-hemispheric transfer of language functions to right homolog regions. This study provides combined evidence of structural and functional brain reorganization of language networks after early stroke with strong implications for neurobiological models of language development

Leigh syndrome is the main clinical characteristic of PTCD3 deficiency

Mitochondrial translation defects are a continuously growing group of disorders showing a large variety of clinical symptoms including a wide range of neurological abnormalities. To date, mutations in PTCD3, encoding a component of the mitochondrial ribosome, have only been reported in a single individual with clinical evidence of Leigh syndrome. Here, we describe three additional PTCD3 individuals from two unrelated families, broadening the genetic and phenotypic spectrum of this disorder, and provide definitive evidence that PTCD3 deficiency is associated with Leigh syndrome. The patients presented in the first months of life with psychomotor delay, respiratory insufficiency and feeding difficulties. The neurologic phenotype included dystonia, optic atrophy, nystagmus and tonic-clonic seizures. Brain MRI showed optic nerve atrophy and thalamic changes, consistent with Leigh syndrome. WES and RNA-seq identified compound heterozygous variants in PTCD3 in both families: c.[1453-1G>C];[1918C>G] and c.[710del];[902C>T]. The functional consequences of the identified variants were determined by a comprehensive characterization of the mitochondrial function. PTCD3 protein levels were significantly reduced in patient fibroblasts and, consistent with a mitochondrial translation defect, a severe reduction in the steady state levels of complexes I and IV subunits was detected. Accordingly, the activity of these complexes was also low, and high-resolution respirometry showed a significant decrease in the mitochondrial respiratory capacity. Functional complementation studies demonstrated the pathogenic effect of the identified variants since the expression of wild-type PTCD3 in immortalized fibroblasts restored the steady-state levels of complexes I and IV subunits as well as the mitochondrial respiratory capacity. Additionally, minigene assays demonstrated that three of the identified variants were pathogenic by altering PTCD3 mRNA processing. The fourth variant was a frameshift leading to a truncated protein. In summary, we provide evidence of PTCD3 involvement in human disease confirming that PTCD3 deficiency is definitively associated with Leigh syndrome.© 2022 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology

El concepto de Praelatus desde los orígenes hasta la Alta Edad Media

Pretendemos con el presente trabajo publicar un extracto de la tesis doctoral presentada en la Facultad de Teología de la Universidad de Navarra en 1988, con el título «El concepto de praelatus desde los orígenes hasta la Alta Edad Media». Consideramos que es un extracto de la entera tesis doctoral puesto que de los siete capítulos de que consta, hemos prescindido solamente del relativo a las Fuentes Epigráficas, por confirmar cuanto hemos obtenido de los testimonios documentales. El objeto de esta investigación es estudiar la evolución del concepto de praelatus desde sus orígenes hasta la Alta Edad Media; es decir, desde que se encuentran los primeros testimonios del uso de dicho término hasta el siglo X. El desarrollo del contenido de praelatus está muy relacionado con la evolución experimentada por las palabras antistes y praesul, que culmina con la asunción por parte del derivado de praelatus en las lenguas romances, del significado bajolatino de los mencionados términos