156 research outputs found
Iron and Calcium Biomineralizations in the Pampean Coastal Plains, Argentina: Their Role in the Environmental Reconstruction of the Holocene
Biomineralizations are biogenic composites, crystalline or amorphous,produced by the metabolic activity of organisms distributed all over the world. Theaim of this work was to evaluate the presence of iron and calcium biomineralizationsand their influence in the physicochemical and mineralochemical variations inpaleo and actual pedosedimentary sequences of the coastal plains in Mar Chiquita.The complex interaction of calcium with iron biomineralizations, as framboidal andpoliframboidal pyrites associated with gypsum, barite, calcite, halite, and iron oxyhydroxides,have demonstrated the active and complex biogeochemistry that occursin the temperate?wet paleoesturaries and estuaries of the coastal Pampean Plains.Particularly the consequences that different human activities could have.Fil: Osterrieth, Margarita Luisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Frayssinet, Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Geología de Costas y del Cuaternario. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto de Geología de Costas y del Cuaternario; ArgentinaFil: Frayssinet, Lucrecia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentin
LibraRing: An Architecture for Distributed Digital Libraries Based on DHTs
Abstract. We present a digital library architecture based on distributed hash tables. We discuss the main components of this architecture and the protocols for offering information retrieval and information filtering functionality. We present an experimental evaluation of our proposals.
Understanding Helical Magnetic Dynamo Spectra with a Nonlinear Four-Scale Theory
Recent MHD dynamo simulations for magnetic Prandtl number demonstrate
that when MHD turbulence is forced with sufficient kinetic helicity, the
saturated magnetic energy spectrum evolves from having a single peak below the
forcing scale to become doubly peaked with one peak at the system (=largest)
scale and one at the forcing scale. The system scale field growth is well
modeled by a recent nonlinear two-scale nonlinear helical dynamo theory in
which the system and forcing scales carry magnetic helicity of opposite sign.
But a two-scale theory cannot model the shift of the small-scale peak toward
the forcing scale. Here I develop a four-scale helical dynamo theory which
shows that the small-scale helical magnetic energy first saturates at very
small scales, but then successively saturates at larger values at larger
scales, eventually becoming dominated by the forcing scale. The transfer of the
small scale peak to the forcing scale is completed by the end of the kinematic
growth regime of the large scale field, and does not depend on magnetic
Reynolds number for large . The four-scale and two-scale theories
subsequently evolve almost identically, and both show significant field growth
on the system and forcing scales that is independent of . In the present
approach, the helical and nonhelical parts of the spectrum are largely
decoupled. Implications for fractionally helical turbulence are discussed.Comment: 19 Pages, LaTex, (includes 4 figs at the end), in press, MNRA
Turbulent Dynamos and Magnetic Helicity
It is shown that the turbulent dynamo -effect converts magnetic
helicity from the turbulent field to the mean field when the turbulence is
electromagnetic while the magnetic helicity of the mean-field is transported
across space when the turbulence is electrostatic or due to the electron
diamagnetic effect. In all cases, however, the dynamo effect strictly conserves
the total helicity except for resistive effects and a small battery effect.
Implications for astrophysical situations, especially for the solar dynamo, are
discussed.Comment: 5 pages, 1 figur
Standard smoking cessation services in sites participating in the SCIMITAR+ trial for people with severe mental ill health
Aims and methodThe SCIMITAR+ trial was commissioned to evaluate the effectiveness of a bespoke smoking cessation intervention for people with severe mental ill health compared with usual services. It is difficult to define what constitutes usual care in smoking cessation services. We aimed to define what this was during the trial. Twenty-two National Health Service healthcare providers participated in a bespoke survey asking about usual care in their area. RESULTS: All sites offered smoking cessation support; however, service provider and service type varied substantially. In some cases services were not streamlined, meaning that people received smoking cessation counselling from one organisation and smoking cessation medication from another.Clinical implicationsTo better implement the National Institute for Health and Care Excellence guideline PH48, clearer referral pathways need to be implemented and communicated to patients, staff and carers. People with severe mental ill health need to be able to access services that combine nicotine replacement therapy and behavioural support in a streamlined manner.Declaration of interestNone
Floating Patches of HCN at the Surface of Their Aqueous Solutions - Can They Make "HCN World" Plausible?
The liquid/vapor interface of the aqueous solutions of HCN of different concentrations has been investigated using molecular dynamics simulation and intrinsic surface analysis. Although HCN is fully miscible with water, strong interfacial adsorption of HCN is observed at the surface of its aqueous solutions, and, at the liquid surface, the HCN molecules tend to be located even at the outer edge of the surface layer. It turns out that in dilute systems the HCN concentration can be about an order of magnitude larger in the surface layer than in the bulk liquid phase. Furthermore, HCN molecules show a strong lateral self-association behavior at the liquid surface, forming thus floating HCN patches at the surface of their aqueous solutions. Moreover, HCN molecules are staying, on average, an order of magnitude longer at the liquid surface than water molecules, and this behavior is more pronounced at smaller HCN concentrations. Because of this enhanced dynamical stability, the floating HCN patches can provide excellent spots for polymerization of HCN, which can be the key step in the prebiotic synthesis of partially water-soluble adenine. All of these findings make the hypothesis of "HCN world" more plausible
Successful recruitment to trials : findings from the SCIMITAR+ Trial
BACKGROUND: Randomised controlled trials (RCT) can struggle to recruit to target on time. This is especially the case with hard to reach populations such as those with severe mental ill health. The SCIMITAR+ trial, a trial of a bespoke smoking cessation intervention for people with severe mental ill health achieved their recruitment ahead of time and target. This article reports strategies that helped us to achieve this with the aim of aiding others recruiting from similar populations. METHODS: SCIMITAR+ is a multi-centre pragmatic two-arm parallel-group RCT, which aimed to recruit 400 participants with severe mental ill health who smoke and would like to cut down or quit. The study recruited primarily in secondary care through community mental health teams and psychiatrists with a smaller number of participants recruited through primary care. Recruitment opened in October 2015 and closed in December 2016, by which point 526 participants had been recruited. We gathered information from recruiting sites on strategies which led to the successful recruitment in SCIMITAR+ and in this article present our approach to trial management along with the strategies employed by the recruiting sites. RESULTS: Alongside having a dedicated trial manager and trial management team, we identified three main themes that led to successful recruitment. These were: clinicians with a positive attitude to research; researchers and clinicians working together; and the use of NHS targets. The overriding theme was the importance of relationships between both the researchers and the recruiting clinicians and the recruiting clinicians and the participants. CONCLUSIONS: This study makes a significant contribution to the limited evidence base of real-world cases of successful recruitment to RCTs and offers practical guidance to those planning and conducting trials. Building positive relationships between clinicians, researchers and participants is crucial to successful recruitment
Universal Sequence Replication, Reversible Polymerization and Early Functional Biopolymers: A Model for the Initiation of Prebiotic Sequence Evolution
Many models for the origin of life have focused on understanding how evolution can drive the refinement of a preexisting enzyme, such as the evolution of efficient replicase activity. Here we present a model for what was, arguably, an even earlier stage of chemical evolution, when polymer sequence diversity was generated and sustained before, and during, the onset of functional selection. The model includes regular environmental cycles (e.g. hydration-dehydration cycles) that drive polymers between times of replication and functional activity, which coincide with times of different monomer and polymer diffusivity. Template-directed replication of informational polymers, which takes place during the dehydration stage of each cycle, is considered to be sequence-independent. New sequences are generated by spontaneous polymer formation, and all sequences compete for a finite monomer resource that is recycled via reversible polymerization. Kinetic Monte Carlo simulations demonstrate that this proposed prebiotic scenario provides a robust mechanism for the exploration of sequence space. Introduction of a polymer sequence with monomer synthetase activity illustrates that functional sequences can become established in a preexisting pool of otherwise non-functional sequences. Functional selection does not dominate system dynamics and sequence diversity remains high, permitting the emergence and spread of more than one functional sequence. It is also observed that polymers spontaneously form clusters in simulations where polymers diffuse more slowly than monomers, a feature that is reminiscent of a previous proposal that the earliest stages of life could have been defined by the collective evolution of a system-wide cooperation of polymer aggregates. Overall, the results presented demonstrate the merits of considering plausible prebiotic polymer chemistries and environments that would have allowed for the rapid turnover of monomer resources and for regularly varying monomer/polymer diffusivities
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