6,155 research outputs found
Cell Therapy for Type 1 Diabetes
Acknowledgements The work described in this review was supported by a grant from the MRC. K.R.M. is supported by a fellowship from the Scottish Translational Medicines and Therapeutics Initiative through the Wellcome Trust.Peer reviewedPublisher PD
Growing communities through nature: research report
This is the final version.Growing Communities Through Nature was designed to test models for community engagement in co-production and local innovation, following this up with co-designed and co-delivered maintenance, monitoring and evaluation activity. The research team investigated the impact of using three different institutional vehicles for bringing together communities around local activity. The project worked in three Cornish towns - Launceston, Helston and Newquay - to run workshops co-designing public open spaces in collaboration with a number of partners. The workshops aimed to bring people together to share ideas about an existing space and its potential improvement, discuss new designs for the site and how to maintain the space, as well as monitoring and evaluating its impact on biodiversity and the local community. In addition to the benefits of climate change mitigation, the development of deeper working relationships between the University, partner organisations and the public provides a blueprint for further integration between higher education institutions and communities. Experience of using co-design, co-delivery and co-monitoring methods and tools provides a foundation from which the partners can develop future place-based activities to respond to a range of needs and challenges (such as community development and housing schemes). This approach could also be scaled-up to other Cornish towns and villages via larger collaborative funding applications. This research report documents the project, peoplesâ experiences and the wider implications.UKR
On representations of super coalgebras
The general structure of the representation theory of a -graded
coalgebra is discussed. The result contains the structure of Fourier analysis
on compact supergroups and quantisations thereof as a special case. The general
linear supergroups serve as an explicit illustration and the simplest example
is carried out in detail.Comment: 18 pages, LaTeX, KCL-TH-94-
Approximating a Wavefunction as an Unconstrained Sum of Slater Determinants
The wavefunction for the multiparticle Schr\"odinger equation is a function
of many variables and satisfies an antisymmetry condition, so it is natural to
approximate it as a sum of Slater determinants. Many current methods do so, but
they impose additional structural constraints on the determinants, such as
orthogonality between orbitals or an excitation pattern. We present a method
without any such constraints, by which we hope to obtain much more efficient
expansions, and insight into the inherent structure of the wavefunction. We use
an integral formulation of the problem, a Green's function iteration, and a
fitting procedure based on the computational paradigm of separated
representations. The core procedure is the construction and solution of a
matrix-integral system derived from antisymmetric inner products involving the
potential operators. We show how to construct and solve this system with
computational complexity competitive with current methods.Comment: 30 page
Concentrations of Polychlorinated Biphenyls (PCBâs), Chlorinated Pesticides, and Heavy Metals and Other Elements in Tissues of Belugas, Delphinapterus leucas, from Cook Inlet
Tissues from Cook Inlet beluga whales, Delphinapterus leucas, that were collected as part of the Alaska Marine Mammal Tissue Archival Project were analyzed for polychlorinated biphenyls (PCBâs), chlorinated pesticides, and heavy metals and other elements. Concentrations of total PCBâs (ÎŁPCBâs), total DDT (ÎŁDDT), chlordane compounds, hexachlorobenzene (HCB), dieldrin, mirex, toxaphene, and hexachlorocyclohexane (HCH) measured in Cook Inlet beluga blubber were compared with those reported for belugas from two Arctic Alaska locations (Point Hope and Point Lay), Greenland, Arctic Canada, and the highly contaminated stock from the St. Lawrence estuary in eastern Canada. The Arctic and Cook Inlet belugas had much lower concentrations (ÎŁPCBâs and ÎŁDDT were an order of magnitude lower) than those found in animals from the St. Lawrence estuary. The Cook Inlet belugas had the lowest concentrations of all (ÎŁPCBâs aver-aged 1.49 ± 0.70 and 0.79 ± 0.56 mg/kg wet mass, and ÎŁDDT averaged 1.35 ± 0.73 and 0.59 ± 0.45 mg/kg in males and females, respectively). Concentrations in the blubber of the Cook Inlet males were significantly lower than those found in the males of the Arctic Alaska belugas (ÎŁPCBâs and ÎŁDDT were about half). The lower levels in the Cook Inlet animals might be due to differences in contaminant sources, food web differences, or different age distributions among the animals sampled. Cook Inlet males had higher mean and median concentrations than did females, a result attributable to the transfer of these compounds from mother to calf during pregnancy and during lactation. Liver concentrations of cadmium and mercury were lower in the Cook Inlet belugas (most cadmium values were <1 mg/kg and mercury values were 0.704â11.42 mg/kg wet mass), but copper levels were significantly higher in the Cook Inlet animals (3.97â123.8 mg/kg wet mass) than in Arctic Alaska animals and similar to those reported for belugas from Hudson Bay. Although total mercury levels were the lowest in the Cook Inlet population, methylmercury concentrations were similar among all three groups of the Alaska animals examined (0.34â2.11 mg/kg wet mass). As has been reported for the Point Hope and Point Lay belugas, hepatic concentrations of silver were r
Lassoing and corraling rooted phylogenetic trees
The construction of a dendogram on a set of individuals is a key component of
a genomewide association study. However even with modern sequencing
technologies the distances on the individuals required for the construction of
such a structure may not always be reliable making it tempting to exclude them
from an analysis. This, in turn, results in an input set for dendogram
construction that consists of only partial distance information which raises
the following fundamental question. For what subset of its leaf set can we
reconstruct uniquely the dendogram from the distances that it induces on that
subset. By formalizing a dendogram in terms of an edge-weighted, rooted
phylogenetic tree on a pre-given finite set X with |X|>2 whose edge-weighting
is equidistant and a set of partial distances on X in terms of a set L of
2-subsets of X, we investigate this problem in terms of when such a tree is
lassoed, that is, uniquely determined by the elements in L. For this we
consider four different formalizations of the idea of "uniquely determining"
giving rise to four distinct types of lassos. We present characterizations for
all of them in terms of the child-edge graphs of the interior vertices of such
a tree. Our characterizations imply in particular that in case the tree in
question is binary then all four types of lasso must coincide
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