Wavelength-tunable picosecond pulses from a passively mode-locked figure-eight Erbium-doped fiber laser with a Sagnac fiber filter

We experimentally demonstrated a wavelength-tunable passively mode-locked Erbium-doped figure-eight fiber laser. Wide tunability is achieved using a high-birefringence (hi-bi) fiber Sagnac loop. The filter transmission function is controlled by selecting the hi-bi fiber loop length. The output pulses are wavelength tunable over a range from 1525 nm to 1555 nm. The FWHM of the autocorrelation trace is about 3.1 ps and the pulse spectrum has a FWHM of 1.5 nm. The pulse temporal and spectral widths remain constant over the tunable range

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism

Genome-wide association studies (GWASs) have identified 19 susceptibility loci for Alzheimer’s disease (AD). However, understanding how these genes are involved in the pathophysiology of AD is one of the main challenges of the “post-GWAS” era. At least 123 genes are located within the 19 susceptibility loci; hence, a conventional approach (studying the genes one by one) would not be time- and cost-effective. We therefore developed a genome-wide, high-content siRNA screening approach and used it to assess the functional impact of gene under-expression on APP metabolism. We found that 832 genes modulated APP metabolism. Eight of these genes were located within AD susceptibility loci. Only FERMT2 (a β3-integrin co-activator) was also significantly associated with a variation in cerebrospinal fluid Aβ peptide levels in 2886 AD cases. Lastly, we showed that the under-expression of FERMT2 increases Aβ peptide production by raising levels of mature APP at the cell surface and facilitating its recycling. Taken as a whole, our data suggest that FERMT2 modulates the AD risk by regulating APP metabolism and Aβ peptide production

Actively mode-locked all-fiber laser by 5 MHz transmittance modulation of an acousto-optic tunable bandpass filter

Active mode-locking of an all-fiber ring laser by transmittance modulation of an in-fiber acousto-optic tunable bandpass filter (AOTBF) is reported. Cavity loss modulation is achieved by full acousto-optic mode re-coupling cycle induced by standing flexural acoustic waves. The modulator permits the implementation of 28 dB of nonresonant light suppression, 1.4 nm of modulation bandwidth, 74% of modulation depth and 4.11 dB of optical loss in a 72.5 cm-long all-fiber configuration. The effects of the modulated AOTBF on the laser performance are investigated. Transform-limited optical pulses of 8.8 ps temporal width and 6.0 W peak power were obtained at 4.87 MHz repetition rate

Q-switched Er/Yb Double Clad Single Mode Fiber Laser

An actively Q-switched Er/Yb double-clad fiber laser is developed at 1549 nm. The pulse width was 34 ns for a repetition rate of 120 kHz with an average output power of 4.0 W

Flat supercontinuum generation pumped by amplified noise-like pulses from a figure-eight erbium-doped fiber laser

The conditions to obtain noise-like pulses (NLPs) from a figure-eight fiber laser (F8L) and their application for supercontinuum (SC) generation in the anomalous dispersion regime are reported. The F8L is designed to remove the undesired low-intensity background radiation from pulse emission, generating NLPs with a 3 dB spectral bandwidth of 17.43 nm at the fundamental repetition frequency of 0.8 MHz. After amplification, NLPs reach a maximum average power of 9.2 mW and 123.32 nm spectral bandwidth. By controlling the amplifier pump power, flat SC generation is demonstrated through both a 800 m long spool of SMF-28 fiber and a piece of 5 m long highly nonlinear optical fiber. The results demonstrate a satisfactory flatness of ~3 dB over a bandwidth of ~1000 nm in the range from 1261 to 2261 nm, achieving to the best of our knowledge, one of the flattest SC generated from noise-like pulse