Estimation of probiotic and vitamine d efficiency in prophylactics of infectious diseases in premature infants

The objective: to study the efficacy of probiotic and vitamin D use in prophylaxis of infectious diseases in premature infants. Materials and methods. The reseach has been conducted on the base of the Odessa National Medical University – neonatal unit of the maternity hospital N 7 (Odessa). The I group consisted of 20 premature infants (PI) who got BioGiy drops. The II group conssted of 19 PI, who got BioGiy drops and vitamin D3. Control group- 23 PI who did not get the preparations mentioned above. At birth and at the age of 3–4 months complex immunological investigation was carried out. Every month the morbidity of PI was observed. Results. PI are more likely to suffer from infectious diseases, functional disorders of the gastrointestinal tract and hypovitaminosis D. The results obtained indicate a high effectiveness of probiotic with vitamin D3 use for the prevention of infectious diseases in PI. The greatest effect was observed in the prevention of skin infections and respiratory diseases of the upper respiratory tract as a reduction of respiratory episodes frequency, acceleration of recovery and lighter course of the disease. Also, the combination of probiotic and vitamin D has proven itself as a means of preventing hypovitaminosis D in PI

Features of premature infants immune system

Premature birth (PB) is the most important aspects in maternal and child health care. The frequency of PB and birth of immature infants is increasing and ranges from 4.0 to 15.0-20.0%. In Ukraine its frequency varies from 3.0% to 12.0%. Preterm infants account for 60-70% of early neonatal and 65-75% of infant mortality. The aim: to examine the main premature baby’s immune system indexes as it is the immune system state that determines survival of a newborn child, the peculiarity of its life in neonatal period, effectiveness of therapeutic and rehabilitation measures, as well as the degree of disability. There were two groups of premature children under study: the I group, n = 62 premature infants, the age of gestation 34-36 weeks without perinatal pathology. The IId group (control ) was represented by 15 healthy newborns, aged 38-40 weeks of gestation. The study was carried out in the first 3 days of the child's life by flow cytofluorometry. In premature infants, the immaturity of the immune system was noted in the form of decrease in all indices of nonspecific immunity: the level of the complement component of C3, the level of immunoglobulins class A, G and M and the values of T-killers and B-lymphocytes