Geometries for universal quantum computation with matchgates

Matchgates are a group of two-qubit gates associated with free fermions. They are classically simulatable if restricted to act between nearest neighbors on a one-dimensional chain, but become universal for quantum computation with longer-range interactions. We describe various alternative geometries with nearest-neighbor interactions that result in universal quantum computation with matchgates only, including subtle departures from the chain. Our results pave the way for new quantum computer architectures that rely solely on the simple interactions associated with matchgates.Comment: 6 pages, 4 figures. Updated version includes an appendix extending one of the result

Indirect tests of the Randall-Sundrum model

I present phenomenological implications of the Randall-Sundrum model for indirect searches, specifically a selection of flavor observables and Higgs-related collider searches. I review the interplay of constraints from CP violation in flavor physics, possible effects in rare decays, and model-specific protection mechanisms. Deviations in the Higgs couplings to fermions and, at one-loop, to gluons are unexpectedly strong and lead to strong modifications in Higgs searches.Comment: 8 pages, 6 figures; Talk given at Discrete '10: Symposium on Prospects in the Physics of Discrete Symmetries, Rome, Italy, 6-11 Dec 201

Gauged flavour symmetry for the light generations

We study the phenomenology of a model where an SU(2)^3 flavour symmetry acting on the first two generation quarks is gauged and Yukawa couplings for the light generations are generated by a see-saw mechanism involving heavy fermions needed to cancel flavour-gauge anomalies. We find that, in constrast to the SU(3)^3 case studied in the literature, most of the constraints related to the third generation, like electroweak precision bounds or B physics observables, can be evaded, while characteristic collider signatures are predicted.Comment: 16 pages, 3 figure

Understanding and assessing the impact of treatment in diabetes: the Treatment-Related Impact Measures for Diabetes and Devices (TRIM-Diabetes and TRIM-Diabetes Device)

<p>Abstract</p> <p>Purpose</p> <p>Diabetes is a debilitating illness requiring lifelong management. Treatments can be varied in terms of mode of administration as well as type of agent. Unfortunately, most patient reported outcome measures currently available to assess the impact of treatment are specific to diabetes type, treatment modality or delivery systems and are designed to be either a HRQoL or treatment satisfaction measure. To address these gaps, the Treatment Related Impact Measure-Diabetes and Device measures were developed. This paper presents the item development and validation of the TRIM Diabetes/Device.</p> <p>Methods</p> <p>Patient interviews were conducted to collect the patient perspective and ensure high content validity. Interviews were hand coded and qualitatively analyzed to identify common themes. A conceptual model of the impact of diabetes medication was developed and preliminary items for the TRIM-Diabetes/Device were generated and cognitively debriefed. Validation data was collected via an on-line survey and analyzed according to an a priori statistical analysis plan to validate the overall score as well as each domain. Item level criteria were used to reduce the preliminary item pool. Next, factor analysis to identify structural domains was performed. Reliability and validity testing was then performed.</p> <p>Results</p> <p>One hundred and five patients were interviewed in focus groups, individual interviews and for cognitive debriefing. Five hundred seven patients participated in the validation study. Factor analysis identified seven domains: Treatment Burden, Daily Life; Diabetes Management; Psychological Health; Compliance and Device Function and Bother. Internal consistency reliability coefficients of the TRIM-Diabetes/Device ranged from 0.80 and 0.94. Test-retest reliability of the TRIM-Diabetes/Device ranged from 0.71 to 0.89. All convergent and known groups validity hypotheses were met for the TRIM-Diabetes/Device total scores and sub-scales.</p> <p>Conclusion</p> <p>Validation is an ongoing and iterative process. These findings are the first step in that process and have shown that both the TRIM-Diabetes and the TRIM-Diabetes Device have acceptable psychometric properties. Future research is needed to continue the validation process and examine responsiveness and the validity of the TRIM-Diabetes/Device in a clinical trial population.</p