3,327 research outputs found
Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes
A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure determinations reveal lanthanide coordination at the sulfonate group, bridging several calixarene units, giving coordination polymers. All complexes in this study have been determined to be relatively non-toxic using in vitro cell assays with CCâ
â values in the range 30â170 ÎźM
Development of PDT/PET theranostics: synthesis and biological evaluation of an šâ¸F-radiolabeled water soluble porphyrin
Synthesis of the first water-soluble porphyrin radiolabeled with fluorine-18 is described: a new molecular theranostic agent which integrates the therapeutic selectivity of photodynamic therapy (PDT) with the imaging efficacy of positron emission tomography (PET). Generation of the theranostic was carried out through the conjugation of a cationic water-soluble porphyrin bearing an azide functionality to a fluorine-18 radiolabeled prosthetic bearing an alkyne functionality through click conjugation, with excellent yields obtained in both cold and hot synthesis. Biological evaluation of the synthesized structures shows the first example of an 18 F-radiolabeled porphyrin retaining photocytotoxicity following radiolabeling and demonstrable conjugate uptake and potential application as a radiotracer in vivo. The promising results gained from biological evaluation demonstrate the potential of this structure as a clinically relevant theranostic agent, offering exciting possibilities for the simultaneous imaging and photodynamic treatment of tumors
Plans for a Neutron EDM Experiment at SNS
The electric dipole moment of the neutron, leptons, and atoms provide a
unique window to Physics Beyond the Standard Model. We are currently developing
a new neutron EDM experiment (the nEDM Experiment). This experiment, which will
be run at the 8.9 A Neutron Line at the Fundamental Neutron Physics Beamline
(FNPB) at the Spallation Neutron Source (SNS) at the Oak Ridge National
Laboratory, will search for the neutron EDM with a sensitivity two orders of
magnitude better than the present limit. In this paper, the motivation for the
experiment, the experimental method, and the present status of the experiment
are discussed.Comment: 9 Pages, 4 Figures, submitted to the proceedings of the Second
Meeting of the APS Topical Group on Hadronic Physics, Nashville, TN, October
22-24, 200
On the X-ray variability of magnetar 1RXS J170849.0-400910
We present a long-term X-ray flux and spectral analysis for 1RXS
J170849.0-400910 using Swift/XRT spanning over 8 years from 2005-2013. We also
analyze two observations from Chandra and XMM in the period from 2003-2004. In
this 10-yr period, 1RXS J170849.0-400910 displayed several rotational glitches.
Previous studies have claimed variations in the X-ray emission associated with
some of the glitches. From our analysis we find no evidence for significant
X-ray flux variations and evidence for only low-level spectral variations. We
also present an updated timing solution for 1RXS J170849.0-400910, from RXTE
and Swift observations, which includes a previously unreported glitch at MJD
56019. We discuss the frequency and implications of radiatively quiet glitches
in magnetars.Comment: 9 pages, 2 figures, accepted for publication in Ap
X-ray Observations of XSS J12270-4859 in a New Low State: A Transformation to a Disk-Free Rotation-Powered Pulsar Binary
We present XMM-Newton and Chandra observations of the low-mass X-ray binary
XSS J12270--4859, which experienced a dramatic decline in optical/X-ray
brightness at the end of 2012, indicative of the disappearance of its accretion
disk. In this new state, the system exhibits previously absent
orbital-phase-dependent, large-amplitude X-ray modulations with a decline in
flux at superior conjunction. The X-ray emission remains predominantly
non-thermal but with an order of magnitude lower mean luminosity and
significantly harder spectrum relative to the previous high flux state. This
phenomenology is identical to the behavior of the radio millisecond pulsar
binary PSR J1023+0038 in the absence of an accretion disk, where the X-ray
emission is produced in an intra-binary shock driven by the pulsar wind. This
further demonstrates that XSS J12270-4859 no longer has an accretion disk and
has transformed to a full-fledged eclipsing "redback" system that hosts an
active rotation-powered millisecond pulsar. There is no evidence for diffuse
X-ray emission associated with the binary that may arise due to outflows or a
wind nebula. An extended source situated 1.5' from XSS J12270--4859 is unlikely
to be associated, and is probably a previously uncatalogued galaxy cluster.Comment: 8 pages, 6 figures; accepted for publication in the Astrophysical
Journa
The SCUBA 8-mJy survey - I: Sub-millimetre maps, sources and number counts
We present maps, source lists, and number counts from the largest, unbiassed,
extragalactic sub-mm survey so far undertaken with the SCUBA camera on the
JCMT. Our maps cover 260 sq. arcmin, to a noise level S(850)=2.5 mJy/beam. We
have reduced the data using both SURF, and our own pipeline which produces
zero-footprint maps and noise images. The uncorrelated noise maps produced by
the latter approach have allowed application of a maximum-likelihood method to
measure the statistical significance of each peak, leading to properly
quantified flux-density errors for all potential sources. We detect 19 sources
with S/N > 4, 38 with S/N > 3.5, and 72 with S/N > 3. To assess completeness
and the impact of source confusion we have applied our source extraction
algorithm to a series of simulated images. The result is a new estimate of the
sub-mm source counts in the flux-density range S(850)=5-15mJy, which we compare
with other estimates, and with model predictions. Our estimate of the
cumulative source count at S(850) > 8 mJy is 320 (+80,-100) per square degree.
Assuming that the majority of sources have z > 1.5, the co-moving number
density of high-z galaxies forming stars at a rate >1000 solar masses per year
is 10^-5 per Mpc^3, with only a weak dependence on the precise redshift
distribution. This number density corresponds to that of massive ellipticals
with L > 3-4 L* at low redshift and is also the same as the co-moving number
density of comparably massive, passively-evolving objects in the redshift band
1<z<2 inferred from recent surveys of extremely red objects. Thus the bright
sub-mm sources can plausibly account for the formation of all present-day
massive ellipticals. Improved z constraints, and a proper measurement of sub-mm
clustering can refine or refute this picture.Comment: Minor revisions. 27 pages, 13 figures. Higher resolution versions of
Figs 5,6,7 and 8 are available from the autho
Comment on ``Measurement of the He mass diffusion coefficient in superfluid He over the 0.45--0.95 K temperature range
The role of 3He-3He collisions in our diffusion experiment is addressed and
shown to not be relevant to the measurement of 3He diffusion against phonons in
superfluid helium.Comment: Two pages, in Europhysics Letters forma
Perspectives of frailty and frailty screening: Protocol for a collaborative knowledge translation approach and qualitative study of stakeholder understandings and experiences
Accompanying the unprecedented growth in the older adult population worldwide is an increase in the prevalence of frailty, an age-related clinical state of increased vulnerability to stressor events. This increased vulnerability results in lower social engagement and quality of life, increased dependency, and higher rates of morbidity, health service utilization and mortality. Early identification of frailty is necessary to guide implementation of interventions to prevent associated functional decline. Consensus is lacking on how to clinically recognize and manage frailty. It is unknown how healthcare providers and healthcare consumers understand and perceive frailty, whether or not they regard frailty as a public health concern; and information on the indirect and direct experiences of consumer and healthcare provider groups towards frailty are markedly limited.We will conduct a qualitative study of consumer, practice nurse, general practitioner, emergency department physician, and orthopedic surgeons' perspectives of frailty and frailty screening in metropolitan and non-metropolitan South Australia. We will use tailored combinations of semi-structured interviews and arts-based data collection methods depending on each stakeholder group, followed by inductive and iterative analysis of data using qualitative description.Using stakeholder driven approaches to understanding and addressing frailty and frailty screening in context is critical as the prevalence and burden of frailty is likely to increase worldwide. We will use the findings from the Perceptions of Frailty and Frailty Screening study to inform a context-driven identification, implementation and evaluation of a frailty-screening tool; drive awareness, knowledge, and skills development strategies across stakeholder groups; and guide future efforts to embed emerging knowledge about frailty and its management across diverse South Australian contexts using a collaborative knowledge translation approach. Study findings will help achieve a coordinated frailty and healthy ageing strategy with relevance to other jurisdictions in Australia and abroad, and application of the stakeholder driven approach will help illuminate how its applicability to other jurisdictions.Mandy M. Archibald, Rachel Ambagtsheer, Justin Beilby, Mellick J. Chehade, Tiffany K. Gill, Renuka Visvanathan, and Alison L. Kitso
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