Textbook Treatment of Structured Programming Standards and Guidelines

COBOL is still the language of choice in most business computer information systems (BCIS). As a result, COBOL remains the language of choice in structured programming courses required in most undergraduate and graduate computer information system (CIS) and business administration curricula in the United States and Canada. The cost of maintaining COBOL systems, however, can be very expensive for business. A collection of structured programming standards and guidelines (SPSGs) for CIS designed with COBOL has evolved to reduce maintenance costs: This review examines SPSG coverage in textbooks currently used in structured programming courses. These textbooks are evaluated and ranked on the basis of SPSG content. In turn, each SPSG is prioritized according to the degree of inter-textbook coverage. Three textbooks and four SPSGs stand out in the research findings along with suggestions for further empirical research

Management Strategies for Enhanced Beef Production on Suckler Cow Farms

While around two thirds the Norwegian beef is produced on dairy cow farms, meat production on specialized beef farms has increased in recent years. The specialized beef industry consists of suckler cow herds producing calves, and farm operations that purchase weaned calves for fattening. A linear programming (LP) model of suckler cow herds, selling weaned calves at 200 days, was developed to study the influence of certain management strategies on profitability. The data were derived from the records of 31 suckler cow herds from three Norwegian regions. The feed costs for silage (roughly half of the feed), NH3-treated straw, concentrate and farm and range pastures were calculated and used as model input. In the model pasture could account for as much as half of the annual feed intake with spring calving on small British breeds and 30% with autumn calving on large continental breeds. In region 1 and 2 in south Norway, late harvesting of roughages and using NH3 treated straw was advantageous compared to earlier harvesting and less concentrates. The growth rate of calves was demonstrated to be an important parameter for the economy in both British and continental breeds. Shortening age at first calving to 2 years, and the calving interval to 12 months was profitable but the gains were small. Similarly, the front-end loading concept with 2/3 of the calves after the first ovulation period, and the remaining in the next, was profitable compared to a similar number (1/3) in three subsequent periods. The economics of a high or low replacement rate was also examined

Policy Measures for Extensive Farming Systems in Southwest Norway

The open landscapes produced over centuries by farming in southwest Norway are threatened by agricultural abandonment, raising public concern for maintenance of the species rich and valuable coastal grasslands. A study in two municipalities revealed that semi-natural grasslands, traditionally grazed in spring and fall and mowed in-between, are most affected. Two linear programming models, one for part time sheep farms and one for larger mixed dairy and meat farms, were developed to study measures for stimulating production, in particular effects on grazing and land utilization of altering support between leys, farm pasture, and grazing animals. Yields and fertilization level in the models were set in accordance with farm account studies. Sheep numbers and grazing can be expanded by hiring more labour and by increased fertilization if profitability is improved. On mixed dairy farms with a milk quota, increased support for grazing might promote a transfer to steers, currently quite uncommon. Prolonging the spring and fall grazing periods should also be considered to improve management of such grasslands, but may increase gastrointestinal nematode problems in the wet coastal climate, and involve less outfield grazing. The analysis demonstrates that idle pasture resources can be utilized by supporting grazing, however, a mixed support system seems appropriate whereas too strong or unilateral support for grazing may lead to increased feed purchases. The balancing of measures targeting grazing animals, leys, and farm pastures can be improved

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

Diverse optogenetic tools have allowed versatile control over neural activity. Many depolarizing and hyperpolarizing tools have now been developed in multiple laboratories and tested across different preparations, presenting opportunities but also making it difficult to draw direct comparisons. This challenge has been compounded by the dependence of performance on parameters such as vector, promoter, expression time, illumination, cell type and many other variables. As a result, it has become increasingly complicated for end users to select the optimal reagents for their experimental needs. For a rapidly growing field, critical figures of merit should be formalized both to establish a framework for further development and so that end users can readily understand how these standardized parameters translate into performance. Here we systematically compared microbial opsins under matched experimental conditions to extract essential principles and identify key parameters for the conduct, design and interpretation of experiments involving optogenetic techniques

Beyond the Red, Purple, and Blue: Election Law Issues in 2012

The Symposium Welcome was given by Clint A. Nichols, the Allen Chair Editor for the University of Richmond Law Review, and Wendy C. Perdue, Dean & Professor of Law at the University of Richmond School of Law. The “Get out the vote?” session was presented by Keesha M. Gaskins, Senior Counsel with the Brennan Center for Justice at New York University; Steven F. Huefner, Professor of Law and Director of Clinical Programs at The Ohio State University Moritz College of Law; Joshua N. Lief, Senior Assistant Attorney General for the Commonwealth of Virginia; and Michael J. Pitts, Professor of Law and Dean’s Fellow at Indiana University’s Robert H. McKinney School of Law. The “Third Parties to the Process” session was presented by Jocelyn F. Benson, Associate Professor of Law at Wayne State University Law School; Joshua A. Douglas, Assistant Professor of Law at the University of Kentucky College of Law; and Rebecca Green, Professor of the Practice of Law and Co-Director of the Election Law Program at the William & Mary Law School. The “Drawing the Lines” session was presented by Keesha M. Gaskins, Senior Counsel with the Brennan Center for Justice at New York University; Dale Ho, Assistant Counsel with the NAACP Legal Defense and Educational Fund; Dr. Michael P. McDonald, Associate Professor of Government and Politics at George Mason University; Donald Palmer, Secretary of the Virginia State Board of Elections; and Rob Richie, Executive Director of FairVote

Organic matter and carbon isotope composition of carbonate nodules and associated sediments from middle valley, leg 139

Carbonate nodules and associated sediments from Ocean Drilling Program Leg 139 sites of the Middle Valley, Juan de Fuca Ridge, were studied using a combination of inorganic and organic geochemical techniques. The mineralogy and stable isotopic compositions defined three types of nodules, reflecting the conditions of carbonate precipitation. Nodule ingrowth has entrapped the sedimentary organic matter, and concomitant displacement of the sedimentary mineral matrix and associated organic matter resulted in decreased bitumen extract yields from the nodules. Molecular organic geochemical analyses of the bitumen by gas chromatography-mass spectrometry revealed that polycyclic aromatic hydrocarbons are major constituents in the total extracts, reflecting the high-temperature origin of the entrapped hydrothermal organic products. Strong reducing conditions are evident during the hydrothermal alteration of biomarker precursors to products. The oxygen isotope data reflect the lower fluid temperatures during carbonate precipitation

Making space for empathy: supporting doctors in the emotional labour of clinical care

BACKGROUND: The academic and medical literature highlights the positive effects of empathy for patient care. Yet, very little attention has been given to the impact of the requirement for empathy on the physicians themselves and on their emotional wellbeing. DISCUSSION: The medical profession requires doctors to be both clinically competent and empathetic towards the patients. In practice, accommodating both requirements can be difficult for physicians. The image of the technically skilful, rational, and emotionally detached doctor dominates the profession, and inhibits physicians from engaging emotionally with their patients and their own feelings, which forms the basis for empathy. This inhibition has a negative impact not only on the patients but also on the physicians. The expression of emotions in medical practice is perceived as unprofessional and many doctors learn to supress and ignore their feelings. When facing stressful situations, these physicians are more likely to suffer from depression and burnout than those who engage with and reflect on their feelings. Physicians should be supported in their emotional work, which will help them develop empathy. Methods could include questionnaires that aid self-reflection, and discussion groups with peers and supervisors on emotional experiences. Yet, in order for these methods to work, the negative image associated with the expression of emotions should be questioned. Also, the work conditions of physicians should improve to allow them to make use of these tools. SUMMARY: Empathy should not only be expected from doctors but should be actively promoted, assisted and cultivated in the medical profession

Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience (EMPOWER) among Surrogate Decision-Makers of ICU Patients: study protocol for a randomized controlled trial

Background Critical illness increases the risk for poor mental health outcomes among both patients and their informal caregivers, especially their surrogate decision-makers. Surrogates who must make life-and-death medical decisions on behalf of incapacitated patients may experience additional distress. EMPOWER (Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience) is a novel cognitive-behavioral, acceptance-based intervention delivered in the intensive care unit (ICU) setting to surrogate decision-makers designed to improve both patients’ quality of life and death and dying as well as surrogates’ mental health. Methods Clinician stakeholder and surrogate participant feedback (n = 15), as well as results from an open trial (n = 10), will be used to refine the intervention, which will then be evaluated through a multisite randomized controlled trial (RCT) (n = 60) to examine clinical superiority to usual care. Feasibility, tolerability, and acceptability of the intervention will be evaluated through self-report assessments. Hierarchical linear modeling will be used to adjust for clustering within interventionists to determine the effect of EMPOWER on surrogate differences in the primary outcome, peritraumatic stress. Secondary outcomes will include symptoms of post-traumatic stress disorder, prolonged grief disorder, and experiential avoidance. Exploratory outcomes will include symptoms of anxiety, depression, and decision regret, all measured at 1 and 3 months from post-intervention assessment. Linear regression models will examine the effects of assignment to EMPOWER versus the enhanced usual care group on patient quality of life or quality of death and intensity of care the patient received during the indexed ICU stay assessed at the time of the post-intervention assessment. Participant exit interviews will be conducted at the 3-month assessment time point and will be analyzed using qualitative thematic data analysis methods. Discussion The EMPOWER study is unique in its application of evidence-based psychotherapy targeting peritraumatic stress to improve patient and caregiver outcomes in the setting of critical illness. The experimental intervention will be strengthened through the input of a variety of ICU stakeholders, including behavioral health clinicians, physicians, bereaved informal caregivers, and open trial participants. Results of the RCT will be submitted for publication in a peer-reviewed journal and serve as preliminary data for a larger, multisite RCT grant application

Amygdala circuitry mediating reversible and bidirectional control of anxiety

Anxiety—a sustained state of heightened apprehension in the absence of immediate threat—becomes severely debilitating in disease states. Anxiety disorders represent the most common of psychiatric diseases (28% lifetime prevalence) and contribute to the aetiology of major depression and substance abuse. Although it has been proposed that the amygdala, a brain region important for emotional processing, has a role in anxiety, the neural mechanisms that control anxiety remain unclear. Here we explore the neural circuits underlying anxiety-related behaviours by using optogenetics with two-photon microscopy, anxiety assays in freely moving mice, and electrophysiology. With the capability of optogenetics to control not only cell types but also specific connections between cells, we observed that temporally precise optogenetic stimulation of basolateral amygdala (BLA) terminals in the central nucleus of the amygdala (CeA)—achieved by viral transduction of the BLA with a codon-optimized channelrhodopsin followed by restricted illumination in the downstream CeA—exerted an acute, reversible anxiolytic effect. Conversely, selective optogenetic inhibition of the same projection with a third-generation halorhodopsin (eNpHR3.0) increased anxiety-related behaviours. Importantly, these effects were not observed with direct optogenetic control of BLA somata, possibly owing to recruitment of antagonistic downstream structures. Together, these results implicate specific BLA–CeA projections as critical circuit elements for acute anxiety control in the mammalian brain, and demonstrate the importance of optogenetically targeting defined projections, beyond simply targeting cell types, in the study of circuit function relevant to neuropsychiatric disease