An improved algorithm for polar cloud-base detection by ceilometer over the ice sheets

Optically thin ice and mixed-phase clouds play an important role in polar regions due to their effect on cloud radiative impact and precipitation. Cloud-base heights can be detected by ceilometers, low-power backscatter lidars that run continuously and therefore have the potential to provide basic cloud statistics including cloud frequency, base height and vertical structure. The standard cloud-base detection algorithms of ceilometers are designed to detect optically thick liquid-containing clouds, while the detection of thin ice clouds requires an alternative approach. This paper presents the polar threshold (PT) algorithm that was developed to be sensitive to optically thin hydrometeor layers (minimum optical depth τ ≥ 0.01). The PT algorithm detects the first hydrometeor layer in a vertical attenuated backscatter profile exceeding a predefined threshold in combination with noise reduction and averaging procedures. The optimal backscatter threshold of 3 × 10^−4 km⁻¹ sr⁻¹ for cloud-base detection near the surface was derived based on a sensitivity analysis using data from Princess Elisabeth, Antarctica and Summit, Greenland. At higher altitudes where the average noise level is higher than the backscatter threshold, the PT algorithm becomes signal-to-noise ratio driven. The algorithm defines cloudy conditions as any atmospheric profile containing a hydrometeor layer at least 90 m thick. A comparison with relative humidity measurements from radiosondes at Summit illustrates the algorithm's ability to significantly discriminate between clear-sky and cloudy conditions. Analysis of the cloud statistics derived from the PT algorithm indicates a year-round monthly mean cloud cover fraction of 72% (±10%) at Summit without a seasonal cycle. The occurrence of optically thick layers, indicating the presence of supercooled liquid water droplets, shows a seasonal cycle at Summit with a monthly mean summer peak of 40 % (±4%). The monthly mean cloud occurrence frequency in summer at Princess Elisabeth is 46% (±5%), which reduces to 12% (±2.5%) for supercooled liquid cloud layers. Our analyses furthermore illustrate the importance of optically thin hydrometeor layers located near the surface for both sites, with 87% of all detections below 500 m for Summit and 80% below 2 km for Princess Elisabeth. These results have implications for using satellite-based remotely sensed cloud observations, like CloudSat that may be insensitive for hydrometeors near the surface. The decrease of sensitivity with height, which is an inherent limitation of the ceilometer, does not have a significant impact on our results. This study highlights the potential of the PT algorithm to extract information in polar regions from various hydrometeor layers using measurements by the robust and relatively low-cost ceilometer instrument

Central Nervous System Siderosis Associated with Multiple Cerebral Aneurysms: Literature Review and Description of an Additional Case

Background: Superficial siderosis (SS) of the central nervous system is a rare disease characterized by deposition of hemosiderin along the leptomeninges due to chronic or recurrent bleeding into the subarachnoid space. The association of unruptured intracranial aneurysm (IA) and cortical SS is quite rare. Methods: A systematic literature review to assess possible commonalities and/or differences of previous reported cases was undertaken. We report an additional case from our institution. Results: A 40-year-old woman presented with a history of generalized seizures over the past year. There was no clinical history suggestive of aneurysm rupture. Magnetic resonance imaging revealed 2 aneurysms of the right middle cerebral artery (MCA) bifurcation associated with hemosiderin deposition along the right sylvian fissure and a third aneurysm of the left MCA bifurcation. Magnetic resonance imaging showed wall enhancing thickening of the larger right MCA aneurysm. The patient underwent surgical clipping of all 3 MCA aneurysms in a staged procedure. Histological examination revealed hemosiderin deposits within the aneurysm wall and surrounding gliosis. Conclusions: Our literature review found 24 reported cases of unruptured IA associated with cortical SS. The possible source for leakages could be neovessels visible in IA walls. The case reported illustrates an uncommon presentation of recurrent bleeding from an IA as a source of SS. The presence of an apparently unruptured IA surrounded by cortical SS on imaging studies is of high relevance as this should be considered a sign of aneurysm wall instability and should indicate prompt treatment

Observations of Buried Lake Drainage on the Antarctic Ice Sheet.

Between 1992 and 2017, the Antarctic Ice Sheet (AIS) lost ice equivalent to 7.6 ± 3.9 mm of sea level rise. AIS mass loss is mitigated by ice shelves that provide a buttress by regulating ice flow from tributary glaciers. However, ice-shelf stability is threatened by meltwater ponding, which may initiate, or reactivate preexisting, fractures, currently poorly understood processes. Here, through ground penetrating radar (GPR) analysis over a buried lake in the grounding zone of an East Antarctic ice shelf, we present the first field observations of a lake drainage event in Antarctica via vertical fractures. Concurrent with the lake drainage event, we observe a decrease in surface elevation and an increase in Sentinel-1 backscatter. Finally, we suggest that fractures that are initiated or reactivated by lake drainage events in a grounding zone will propagate with ice flow onto the ice shelf itself, where they may have implications for its stability

Factors limiting complete tumor ablation by radiofrequency ablation

The purpose of this study was to determine radiological or physical factors to predict the risk of residual mass or local recurrence of primary and secondary hepatic tumors treated by radiofrequency ablation (RFA). Eighty-two patients, with 146 lesions (80 hepatocellular carcinomas, 66 metastases), were treated by RFA. Morphological parameters of the lesions included size, location, number, ultrasound echogenicity, computed tomography density, and magnetic resonance signal intensity were obtained before and after treatment. Parameters of the generator were recorded during radiofrequency application. The recurrence-free group was statistically compared to the recurrence and residual mass groups on all these parameters. Twenty residual masses were detected. Twenty-nine lesions recurred after a mean follow-up of 18 months. Size was a predictive parameter. Patients\u27 sex and age and the echogenicity and density of lesions were significantly different for the recurrence and residual mass groups compared to the recurrence-free group (p < 0.05). The presence of an enhanced ring on the magnetic resonance control was more frequent in the recurrence and residual mass groups. In the group of patients with residual lesions, analysis of physical parameters showed a significant increase (p < 0.05) in the time necessary for the temperature to rise. In conclusion, this study confirms risk factors of recurrence such as the size of the tumor and emphasizes other factors such as a posttreatment enhanced ring and an increase in the time necessary for the rise in temperature. These factors should be taken into consideration when performing RFA and during follow-up

A daily, 1 km resolution data set of downscaled Greenland ice sheet surface mass balance (1958–2015)

This study presents a data set of daily, 1 km resolution Greenland ice sheet (GrIS) surface mass balance (SMB) covering the period 1958–2015. Applying corrections for elevation, bare ice albedo and accumulation bias, the high-resolution product is statistically downscaled from the native daily output of the polar regional climate model RACMO2.3 at 11 km. The data set includes all individual SMB components projected to a down-sampled version of the Greenland Ice Mapping Project (GIMP) digital elevation model and ice mask. The 1 km mask better resolves narrow ablation zones, valley glaciers, fjords and disconnected ice caps. Relative to the 11 km product, the more detailed representation of isolated glaciated areas leads to increased precipitation over the southeastern GrIS. In addition, the downscaled product shows a significant increase in runoff owing to better resolved low-lying marginal glaciated regions. The combined corrections for elevation and bare ice albedo markedly improve model agreement with a newly compiled data set of ablation measurements

Atmospheric triggers of the Brunt Ice Shelf calving in February 2021

The calving of Antarctic ice shelves remains unpredictable to date due to a lack of understanding of the role of the different climatic components in such events. In this study, the role of atmospheric forcing in the calving of the Brunt Ice Shelf (BIS) in February 2021 is investigated using a combination of observational and reanalysis data. The occurrence of a series of extreme cyclones around the time of the calving induced an oceanward sea surface slope of more than 0.08º leading to the calving along a pre-existing rift. The severe storms were sustained by the development of a pressure dipole on both sides of the BIS associated with a La Niña event and the positive phase of the Southern Annular Mode. Poleward advection of warm and moist low-latitude air over the BIS area just before the calving was also observed in association with atmospheric rivers accompanying the cyclones. Immediately after the calving, strong offshore winds continued and promoted the drift of the iceberg A-74 in the Weddell Sea at a speed up to 700 m day-1. This study highlights the contribution of local atmospheric conditions to ice-shelf dynamics. The link to the larger scale circulation patterns indicates that both need to be accounted for in the projections of Antarctic ice shelf evolution

Immunoregulation of Dendritic Cell Subsets by Inhibitory Receptors in Urothelial Cancer.

Blockade of inhibitory receptors (IRs) overexpressed by T cells can activate antitumor immune responses, resulting in the most promising therapeutic approaches, particularly in bladder cancer, currently able to extend patient survival. Thanks to their ability to cross-present antigens to T cells, dendritic cells (DCs) are an immune cell population that plays a central role in the generation of effective antitumor T-cell responses. While IR function and expression have been investigated in T cells, very few data are available for DCs. Therefore, we analyzed whether DCs express IRs that can decrease their functions. To this end, we investigated several IRs (PD-1, CTLA-4, BTLA, TIM-3, and CD160) in circulating CD1c javax.xml.bind.JAXBElement@4f1331d4 DCs, CD141 javax.xml.bind.JAXBElement@68e4feef DCs, and plasmacytoid DCs from healthy donors and patients with urothelial cancer (UCa). Different DC subsets expressed BTLA and TIM-3 but not other IRs. More importantly, BTLA and TIM-3 were significantly upregulated in DCs from blood of UCa patients. Locally, bladder tumor-infiltrating DCs also overexpressed BTLA and TIM-3 compared to DCs from paired nontumoral tissue. Finally, in vitro functional experiments showed that ligand-mediated engagement of BTLA and TIM-3 receptors significantly reduced the secretion of effector cytokines by DC subpopulations. Our findings demonstrate that UCa induces local and systemic overexpression of BTLA and TIM-3 by DCs that may result in their functional inhibition, highlighting these receptors as potential targets for UCa treatment. We investigated the expression and function of a panel of inhibitory receptors in dendritic cells (DCs), an immune cell subpopulation critical in initiation of protective immune responses, among patients with urothelial carcinoma. We found high expression of BTLA and TIM-3 by blood and tumor DCs, which could potentially mediate decreased DC function. The results suggest that BTLA and TIM-3 might be new targets for urothelial carcinoma treatment

Higher Antarctic ice sheet accumulation and surface melt rates revealed at 2 km resolution

Antarctic ice sheet (AIS) mass loss is predominantly driven by increased solid ice discharge, but its variability is governed by surface processes. Snowfall fluctuations control the surface mass balance (SMB) of the grounded AIS, while meltwater ponding can trigger ice shelf collapse potentially accelerating discharge. Surface processes are essential to quantify AIS mass change, but remain poorly represented in climate models typically running at 25-100 km resolution. Here we present SMB and surface melt products statistically downscaled to 2 km resolution for the contemporary climate (1979-2021) and low, moderate and high-end warming scenarios until 2100. We show that statistical downscaling modestly enhances contemporary SMB (3%), which is sufficient to reconcile modelled and satellite mass change. Furthermore, melt strongly increases (46%), notably near the grounding line, in better agreement with in-situ and satellite records. The melt increase persists by 2100 in all warming scenarios, revealing higher surface melt rates than previously estimated.High-resolution 2-km Antarctic maps reveal higher snowfall and surface melt than low-resolution products, reconciling satellite-observed ice sheet mass change. Projected higher surface melt near grounding lines threatens future ice shelf stability