50 research outputs found
Percolative shunting on electrified surface
The surface discharge of electrified dielectrics at high humidity is
considered. The percolative nature of charge transport in electrets is
established. Particular attention is given to the phenomena of adsorption and
nucleation of electrically conducting phase in the cause of percolation cluster
growth on electrified surface. The critical index of the correlation lenght for
percolation cluster is found, and its value is in good agreement with the known
theoretical estimations.Comment: 4 pages with 1 figure, revtex, published in Tech. Phys. Lett. 25
(1999) 877-879 with one additional figur
Fluctuation Conductivity in Unconventional Superconductors near Critical Disorder
The fluctuation conductivity in bulk superconductors with
non s-wave pairing and with nonmagnetic disorder of strength is studied at
low and within the Gaussian approximation. It is shown by assuming a quasi
two-dimensional (2D) electronic state that, only if the gap function
d_\mu({\p}) is, as in a 2D p-wave pairing state, linear in the in-plane
(relative) momentum {\p}_\perp, the in-plane fluctuation conductivity on the
line is weakly divergent in low limit. The present result may be
useful in clarifying the true gap function of spin-triplet
through resistivity measurements.Comment: 8 pages, 1 figure, to be published in J. Phys. Soc. Jpn. 70, No.10
(2001
Low-Temperatures Vortex Dynamics in Twinned Superconductors
We discuss the low-temperature dynamics of magnetic flux lines in samples
with a family of parallel twin planes. A current applied along the twin planes
drives flux motion in the direction transverse to the planes and acts like an
electric field applied to {\it one-dimensional} carriers in disordered
semiconductors. As in flux arrays with columnar pins, there is a regime where
the dynamics is dominated by superkink excitations that correspond to Mott
variable range hopping (VRH) of carriers. In one dimension, however, rare
events, such as large regions void of twin planes, can impede VRH and dominate
transport in samples that are sufficiently long in the direction of flux
motion. In short samples rare regions can be responsible for mesoscopic
effects.Comment: 4 pages, 2 figures email: [email protected]
On the low temperature properties and specific anisotropy of pure anisotropically paired superconductors
Dependences of low temperature behavior and anisotropy of various physical
quantities for pure unconventional superconductors upon a particular form of
momentum direction dependence for the superconducting order parameter (within
the framework of the same symmetry type of superconducting pairing) are
considered. A special attention is drawn to the possibility of different
multiplicities of the nodes of the order parameter under their fixed positions
on the Fermi surface, which are governed by symmetry. The problem of an
unambiguous identification of a type of superconducting pairing on the basis of
corresponding experimental results is discussed. Quasiparticle density of
states at low energy for both homogeneous and mixed states, the low temperature
dependences of the specific heat, penetration depth and thermal conductivity,
the I-V curves of SS and NS tunnel junctions at low voltages are examined. A
specific anisotropy of the boundary conditions for unconventional
superconducting order parameter near for the case of specular reflection
from the boundary is also investigated.Comment: 20 page
Magnetolocalization in disordered quantum wires
The magnetic field dependent localization in a disordered quantum wire is
considered nonperturbatively.
An increase of an averaged localization length with the magnetic field is
found, saturating at twice its value without magnetic field.
The crossover behavior is shown to be governed both in the weak and strong
localization regime by the magnetic diffusion length L_B. This function is
derived analytically in closed form as a function of the ratio of the mean free
path l, the wire thickness W, and the magnetic length l_B for a two-dimensional
wire with specular boundary conditions, as well as for a parabolic wire. The
applicability of the analytical formulas to resistance measurements in the
strong localization regime is discussed. A comparison with recent experimental
results on magnetolocalization is included.Comment: 22 pages, RevTe
Near-infrared (NIR) spectroscopy. A new method for arthroscopic evaluation of low grade degenerated cartilage lesions. Results of a pilot study
<p>Abstract</p> <p>Background</p> <p>Arthroscopy is a highly sensitive method of evaluating high-grade cartilage lesions but the detection of low-grade lesions is often is unreliable. Objective measurements are required. A novel NIRS (near-infrared-spectroscopy) device for detection of low-grade cartilage defects was evaluated in a preliminary clinical study.</p> <p>Methods</p> <p>In 12 patients who had undergone arthroscopy, the cartilage lesions within the medial knee compartment were classified according to the ICRS protocol.</p> <p>With a NIR spectrometer system and an optical probe, similar in design to a hook used for routine arthroscopy, the optical properties of cartilage were measured during arthroscopy.</p> <p>Results</p> <p>The mean ratio of 2 NIR absorption bands of intact cartilage 3.8 (range 2.3 to 8.7).was significantly lower than that of cartilage with grade 1 lesions (12.8, range 4.8 to 19.6) and grade 2 lesions (13.4, range 10.4 to 15.4).</p> <p>No differences were observed between grade 1 and grade 2 lesions.</p> <p>Conclusion</p> <p>NIRS can be used to distinguish between ICRS grade 1 lesions and healthy cartilage during arthroscopic surgeries. The results of this clinical study demonstrate the potential of NIRS to objectify classical arthroscopic grading systems.</p
Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse.
Semicarbazide-sensitive amine oxidase (SSAO) catalyses oxidative deamination of primary amines. Since there is no data about its function in pain and arthritis mechanisms, we investigated the effects of our novel SSAO inhibitor SzV-1287 in chronic mouse models of joint inflammation. Effects of SzV-1287 (20 mg/kg i.p./day) were investigated in the K/BxN serum-transfer and complete Freund's adjuvant (CFA)-evoked active immunization models compared to the reference SSAO inhibitor LJP-1207. Mechanonociception was assessed by aesthesiometry, oedema by plethysmometry, clinical severity by scoring, joint function by grid test, myeloperoxidase activity by luminescence, vascular leakage by fluorescence in vivo imaging, histopathological changes by semiquantitative evaluation, and cytokines by Luminex assay. SzV-1287 significantly inhibited hyperalgesia and oedema in both models. Plasma leakage and keratinocyte chemoattractant production in the tibiotarsal joint, but not myeloperoxidase activity was significantly reduced by SzV-1287 in K/BxN-arthritis. SzV-1287 did not influence vascular and cellular mechanisms in CFA-arthritis, but significantly decreased histopathological alterations. There was no difference in the anti-hyperalgesic and anti-inflammatory actions of SzV-1287 and LJP-1207, but only SzV-1287 decreased CFA-induced tissue damage. Unlike SzV-1287, LJP-1207 induced cartilage destruction, which was confirmed in vitro. SzV-1287 exerts potent analgesic and anti-inflammatory actions in chronic arthritis models of distinct mechanisms, without inducing cartilage damage
Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis
Nonalcoholic fatty liver disease (NAFLD) encompasses a range of manifestations, including steatosis and cirrhosis. Progressive disease is characterized by hepatic leukocyte accumulation in the form of steatohepatitis. The adhesion molecule vascular adhesion protein-1 (VAP-1) is a membrane-bound amine oxidase that promotes leukocyte recruitment to the liver, and the soluble form (sVAP-1) accounts for most circulating monoamine oxidase activity, has insulin-like effects, and can initiate oxidative stress. Here, we determined that hepatic VAP-1 expression is increased in patients with chronic liver disease and that serum sVAP-1 levels are elevated in patients with NAFLD compared with those in control individuals. In 4 murine hepatic injury models, an absence or blockade of functional VAP-1 reduced inflammatory cell recruitment to the liver and attenuated fibrosis. Moreover, disease was reduced in animals expressing a catalytically inactive form of VAP-1, implicating enzyme activity in the disease pathogenesis. Within the liver, hepatic stromal cells expressed functional VAP-1, and evaluation of cultured cells revealed that sVAP-1 promotes leukocyte migration through catalytic generation of ROS, which depended on VAP-1 enzyme activity. VAP-1 enhanced stromal cell spreading and wound closure and modulated expression of profibrotic genes. Together, these results link the amine oxidase activity of VAP-1 with hepatic inflammation and fibrosis and suggest that targeting VAP-1 has therapeutic potential for NAFLD and other chronic fibrotic liver diseases
Implication for Functions of the Ectopic Adipocyte Copper Amine Oxidase (AOC3) from Purified Enzyme and Cell-Based Kinetic Studies
AOC3 is highly expressed in adipocytes and smooth muscle cells, but its function in these cells is currently unknown. The in vivo substrate(s) of AOC3 is/are also unknown, but could provide an invaluable clue to the enzyme's function. Expression of untagged, soluble human AOC3 in insect cells provides a relatively simple means of obtaining pure enzyme. Characterization of enzyme indicates a 6% titer for the active site 2,4,5-trihydroxyphenylalanine quinone (TPQ) cofactor and corrected kcat values as high as 7 s−1. Substrate kinetic profiling shows that the enzyme accepts a variety of primary amines with different chemical features, including nonphysiological branched-chain and aliphatic amines, with measured kcat/Km values between 102 and 104 M−1 s−1. Km(O2) approximates the partial pressure of oxygen found in the interstitial space. Comparison of the properties of purified murine to human enzyme indicates kcat/Km values that are within 3 to 4-fold, with the exception of methylamine and aminoacetone that are ca. 10-fold more active with human AOC3. With drug development efforts investigating AOC3 as an anti-inflammatory target, these studies suggest that caution is called for when screening the efficacy of inhibitors designed against human enzymes in non-transgenic mouse models. Differentiated murine 3T3-L1 adipocytes show a uniform distribution of AOC3 on the cell surface and whole cell Km values that are reasonably close to values measured using purified enzymes. The latter studies support a relevance of the kinetic parameters measured with isolated AOC3 variants to adipocyte function. From our studies, a number of possible substrates with relatively high kcat/Km have been discovered, including dopamine and cysteamine, which may implicate a role for adipocyte AOC3 in insulin-signaling and fatty acid metabolism, respectively. Finally, the demonstrated AOC3 turnover of primary amines that are non-native to human tissue suggests possible roles for the adipocyte enzyme in subcutaneous bacterial infiltration and obesity