Stabilisation of an amorphous form of ROY through a predicted co-former interaction

The highly polymorphic compound ROY, notorious for the colour of its crystals, was the subject of an optimised high-throughput ultrasound-based co-crystal screen. This screen involved a computational pre-screen which highlighted an interaction between ROY and the potential co-former pyrogallol. We have shown that the presence of pyrogallol stabilises the amorphous form of ROY, highlighting the potential for future prediction of co-amorphous behaviours

Synthesis and Biological Evaluation of Purpurealidin E-Derived Marine Sponge Metabolites: Aplysamine-2, Aplyzanzine A, and Suberedamines A and B

Five purpurealidin-derived marine secondary sponge metabolies have been synthesized through the carbodiimide coupling of an appropriate bromotyrosine unit. The structure elucidations have been confirmed through direct comparison with spectroscopic data of isolated natural products. Aplyzanzine A has been shown to be the most active product against a broad bacterial and fungal screen, demonstrating MIC values 2 to 4 times lower than the other metabolites in this study. Compounds <b>2</b>,<b> 3</b>,<b> 4a</b>, and<b> 5</b>–<b>7</b> exhibit a modest inhibition against slow growing mycobacteria (MIC 25–50 μg/mL), including <i>Mycobacterium tuberculosis</i>. <i>iso</i>-Anomoian A and suberedamine B showed antitumor activity in the NCI-DTP60 cell line screen at single-digit micromolar concentrations, with <i>iso</i>-anomoian A inhibiting 53 cell lines. These molecules present novel scaffolds for further optimization

Versatile Routes to Marine Sponge Metabolites through Benzylidene Rhodanines

The first total synthesis of the marine natural products Psammaplin C and Tokaradine A is described. Benzylidene rhodanines were utilized as versatile intermediates toward the synthesis of seven brominated marine sponge metabolites through the optimization of protection group strategies. Spermatinamine demonstrated good inhibition of all cancer cell lines tested, in particular the leukemia K562 and colon cancer HT29 cell lines

Synthesis and Biological Evaluation of Purpurealidin E-Derived Marine Sponge Metabolites: Aplysamine-2, Aplyzanzine A, and Suberedamines A and B

Five purpurealidin-derived marine secondary sponge metabolies have been synthesized through the carbodiimide coupling of an appropriate bromotyrosine unit. The structure elucidations have been confirmed through direct comparison with spectroscopic data of isolated natural products. Aplyzanzine A has been shown to be the most active product against a broad bacterial and fungal screen, demonstrating MIC values 2 to 4 times lower than the other metabolites in this study. Compounds <b>2</b>,<b> 3</b>,<b> 4a</b>, and<b> 5</b>–<b>7</b> exhibit a modest inhibition against slow growing mycobacteria (MIC 25–50 μg/mL), including <i>Mycobacterium tuberculosis</i>. <i>iso</i>-Anomoian A and suberedamine B showed antitumor activity in the NCI-DTP60 cell line screen at single-digit micromolar concentrations, with <i>iso</i>-anomoian A inhibiting 53 cell lines. These molecules present novel scaffolds for further optimization