A compact minimal shadow boundary in Euclidean space is totally geodesic

We prove that a compact minimal shadow boundary of a hypersurface in Euclidean space is totally geodesic. We show that shadow boundaries detect principal directions and umbilical points of a hypersurface. As application we deduce that every shadow boundary of a compact strictly convex surface contains at least two principal direction

El efecto indirecto sobre el rendimiento de la integración de los stakeholders

La literatura, tanto desde el enfoque instrumental como normativo de la Teoría de los Stakeholders, ha resaltado la influencia en el resultado de las relaciones con los grupos de interés (GI), pero este efecto se ha analizado de forma directa. En el presente trabajo, desarrollamos la influencia de la integración de los GI en el rendimiento empresarial, no de forma directa sino indirecta, a través de otras capacidades. Exponemos que la integración de los GI influye de forma indirecta sobre el rendimiento a través de otras capacidades empresariales como la innovación o el aprendizaje organizativo. Además, exponemos que este efecto indirecto se produce de dos formas: bien como elemento potenciador de esas capacidades, o bien como activo complementario sobre el resultado.Existent literature, both from the instrumental as well as the normative Stakeholders’ Theory scope, has highlighted the influence of the relationships with the stakeholders on the enterprises´ performance, but this effect has been analyzed from a direct perspective. In the current paper, we develop the influence of the stakeholders’ integration on the enterprises´ performance, not from a direct way but using an indirect perspective, through other capacities such us innovation, or organizational learning. In addition, we argue that this indirect effect takes place in two ways: as a strengthen element of those capacities, or as a complementary asset on performance

La integración de los stakeholders en la empresa: identificación de sus principales dimensiones

La importancia de los Stakeholders en el mundo empresarial actual hace que las empresas estén obligadas a tenerlos en cuenta, y les provoca la necesidad de realizar esfuerzos en integrar las demandas de sus grupos de interés (GI) en las políticas y prioridades de la firma para conseguir su satisfacción. Tras analizar los distintos aspectos que se han tenido en cuenta para analizar las relaciones con los Stakeholders, y utilizando tanto el enfoque descriptivo como normativo de la teoría, identificamos tres dimensiones en el proceso de integración de los GI: el conocimiento de los GI, su implicación en la empresa a través de la consulta y la participación y la modificación de políticas y objetivos para adaptarse a sus demandas. Estas dimensiones se identifican especialmente relevantes para conseguir la satisfacción de los grupos de interés.The importance of Stakeholders in the current managerial world is forcing companies to keep them continually in mind. In addition, it causes the necessity of carrying out efforts aimed at integrating stakeholders’ demands into their politics and priorities in order to achieve their satisfaction. After analyzing the different aspects considered in the study of relationships with Stakeholders, and using both a descriptive and normative theory scope, we identify three dimensions in the process of stakeholders´ integration: the knowledge about them, their implication in the company through consulting and participation, and finally, the modification of enterprises’ politics and objectives in order to adapt to their demands. These dimensions are considered to be of special importance in ensuring Stakeholders’ satisfaction

Comunicación con los padres, malestar psicológico y actitud hacia la autoridad en adolescentes mexicanos: su influencia en la victimización escolar

Las consecuencias de la victimización escolar en los adolescentes demandan una mayor comprensión de las relaciones entre los factores involucrados. Se seleccionó una muestra representativa y aleatoria por conglomerados, que incluía 1.698 estudiantes mexicanos de Secundaria (46% niños y 54% niñas), de 12 a 17 años (M = 13.65. DE = 1.14). Los datos de auto-reporte sobre comunicación con los padres, malestar psicológico y actitud positiva hacia la autoridad institucional se analizaron con la técnica del análisis estructural. El modelo estructural resultante confirmó una relación indirecta de la comunicación padres-adolescentes con la victimización escolar, a través del malestar psicológico y la actitud positiva hacia la autoridad institucional, demostrando la influencia de la calidad de la comunicación con sus padres sobre la victimización escolar de los adolescentes.Consequences of adolescent's school victimization compel a better understanding of the relations between infl uential factors. A randomized representative sample, was selected by conglomerates, including 1.698 Mexican adolescents (46% boys and 54% girls), with ages between 12-17 years (M = 13.65. SD = 1.14) attending secondary school. Self-report data about parents- adolescent communication, psychological distress and positive attitude toward institutional authority were analyzed using structural analysis. The resulting path structural model confi rmed an indirect relation between parents-adolescent communication and school victimization trough psychological distress and a positive attitude toward institutional authority, underscoring the influence of parents-adolescent communication over adolescent`s school victimization

Glioblastoma Therapy with Cytotoxic Mesenchymal Stromal Cells Optimized by Bioluminescence Imaging of Tumor and Therapeutic Cell Response

Genetically modified adipose tissue derived mesenchymal stromal cells (hAMSCs) with tumor homing capacity have been proposed for localized therapy of chemo- and radiotherapy resistant glioblastomas. We demonstrate an effective procedure to optimize glioblastoma therapy based on the use of genetically modified hAMSCs and in vivo non invasive monitoring of tumor and therapeutic cells. Glioblastoma U87 cells expressing Photinus pyralis luciferase (Pluc) were implanted in combination with hAMSCs expressing a trifunctional Renilla reniformis luciferase-red fluorescent protein-thymidine kinase reporter in the brains of SCID mice that were subsequently treated with ganciclovir (GCV). The resulting optimized therapy was effective and monitoring of tumor cells by bioluminescence imaging (BLI) showed that after 49 days GCV treatment reduced significantly the hAMSC treated tumors; by a factor of 104 relative to controls. Using a Pluc reporter regulated by an endothelial specific promoter and in vivo BLI to image hAMSC differentiation we gained insight on the therapeutic mechanism. Implanted hAMSCs homed to tumor vessels, where they differentiated to endothelial cells. We propose that the tumor killing efficiency of genetically modified hAMSCs results from their association with the tumor vascular system and should be useful vehicles to deliver localized therapy to glioblastoma surgical borders following tumor resection

Overexpression of circulating MiR-30b-5p identifies advanced breast cancer

Breast cancer (BrC) remains the leading cause of cancer-related death in women, mainly due to recurrent and/or metastatic events, entailing the need for biomarkers predictive of progression to advanced disease. MicroRNAs hold promise as noninvasive cancer biomarkers due to their inherent stability and resilience in tissues and bodily fluids. There is increasing evidence that specific microRNAs play a functional role at different steps of the metastatic cascade, behaving as signaling mediators to enable the colonization of a specific organ. Herein, we aimed to evaluate the biomarker performance of microRNAs previously reported as associated with prognosis for predicting BrC progression in liquid biopsies. Background Breast cancer (BrC) remains the leading cause of cancer-related death in women, mainly due to recurrent and/or metastatic events, entailing the need for biomarkers predictive of progression to advanced disease. MicroRNAs hold promise as noninvasive cancer biomarkers due to their inherent stability and resilience in tissues and bodily fluids. There is increasing evidence that specific microRNAs play a functional role at different steps of the metastatic cascade, behaving as signaling mediators to enable the colonization of a specific organ. Herein, we aimed to evaluate the biomarker performance of microRNAs previously reported as associated with prognosis for predicting BrC progression in liquid biopsies. Methods Selected microRNAs were assessed using a quantitative reverse transcription-polymerase chain reaction in a testing cohort of formalin-fixed paraffin-embedded primary (n = 16) and metastatic BrC tissues (n = 22). Then, miR-30b-5p and miR-200b-3p were assessed in a validation cohort #1 of formalin-fixed paraffin-embedded primary (n = 82) and metastatic BrC tissues (n = 93), whereas only miR-30b-5p was validated on a validation cohort #2 of liquid biopsies from BrC patients with localized (n = 20) and advanced (n = 25) disease. ROC curve was constructed to evaluate prognostic performance. Results MiR-30b-5p was differentially expressed in primary tumors and paired metastatic lesions, with bone metastases displaying significantly higher miR-30b-5p expression levels, paralleling the corresponding primary tumors. Interestingly, patients with advanced disease disclosed increased circulating miR-30b-5p expression compared to patients with localized BrC. Conclusions MiR-30b-5p might identify BrC patients at higher risk of disease progression, thus, providing a useful clinical tool for patients’ monitoring, entailing earlier and more effective treatment. Nonetheless, validation in larger multicentric cohorts is mandatory to confirm these findings.Research Center of Portuguese Oncology Institute of Porto (PI 74-CI-IPOP-19-2016). JL and CSG are supported by a PhD fellowship from FCT - Fundação para a Ciência e Tecnologia (SFRH/ BD/132751/2017 and SFRH/BD/92786/2013, respectively). SS is supported by a PhD fellowship IPO/ESTIMA-1 NORTE-01-0145-FEDER-000027. BMC is funded by FCT-Fundação para a Ciência e a Tecnologia (IF/00601/2012

Adult Prevalence of Epilepsy in Spain: EPIBERIA, a Population-Based Study

Background. This study assesses the lifetime and active prevalence of epilepsy in Spain in people older than 18 years. Methods. EPIBERIA is a population-based epidemiological study of epilepsy prevalence using data from three representative Spanish regions (health districts in Zaragoza, Almería, and Seville) between 2012 and 2013. The study consisted of two phases: screening and confirmation. Participants completed a previously validated questionnaire (EPIBERIA questionnaire) over the telephone. Results. A total of 1741 valid questionnaires were obtained, including 261 (14.99%) raising a suspicion of epilepsy. Of these suspected cases, 216 (82.75%) agreed to participate in phase 2. Of the phase 2 participants, 22 met the International League Against Epilepsy’s diagnostic criteria for epilepsy. The estimated lifetime prevalence, adjusted by age and sex per 1,000 people, was 14.87 (95% CI: 9.8–21.9). Active prevalence was 5.79 (95% CI: 2.8–10.6). No significant age, sex, or regional differences in prevalence were detected. Conclusions. EPIBERIA provides the most accurate estimate of epilepsy prevalence in the Mediterranean region based on its original methodology and its adherence to ILAE recommendations. We highlight that the lifetime prevalence and inactive epilepsy prevalence figures observed here were compared to other epidemiological studies

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio