3,961 research outputs found
Mechanomics and physicomics in gravisensing
Link to publication General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Abstract Sensing gravity by 'non-specialized' cells is still puzzling. We don't know where or by which mechanism such cells sense gravity. These questions in 'gravisensing' are not much different from questions in general mechanobiology. Numerous studies have been reported in this field in the last couple of decades. What are the mechanical properties of a cell? Are there differences in mechanical properties between cell types and if so why? How are forces perceived and transduced to a meaningful biological event. Novel techniques such as optical and magnetic tweezers, atomic force microscopy, magnetophoresis and computer modeling make the field of mechanosensing or perhaps physicomics accessible. A similar approach should also be applied for gravity-related research. This paper addresses the current techniques used in mechanosensing and exemplifies how a cell could sense the relatively weak force of gravity
Gravity effects on a gliding arc in four noble gases: from normal to hypergravity
A gliding arc in four noble gases (He, Ne, Ar, Kr) has been studied under previously unexplored conditions of varying artifiial gravity, from normal 1 g gravity up to 18 g hypergravity. Signifiant differences, mainly the visual thickness of the plasma channel, its maximum elongation and general sensitivity to hypergravity conditions, were observed between the discharges in individual gases, resulting from their different atomic weights and related quantities, such as heat conductivity or ionisation potential. Generally, an increase of the artifiial gravity level leads to a faster plasma channel movement thanks to stronger buoyant force and a decrease of maximum height reached by the channel due to more intense losses of heat and reactive species. In relation to this, an increase in current and a decrease in absorbed power was observed
Evaluation of drought propagation in an ensemble mean of large-scale hydrological models
Hydrological drought is increasingly studied using large-scale models. It is, however, not sure whether large-scale models reproduce the development of hydrological drought correctly. The pressing question is how well do large-scale models simulate the propagation from meteorological to hydrological drought? To answer this question, we evaluated the simulation of drought propagation in an ensemble mean of ten large-scale models, both land-surface models and global hydrological models, that participated in the model intercomparison project of WATCH (WaterMIP). For a selection of case study areas, we studied drought characteristics (number of droughts, duration, severity), drought propagation features (pooling, attenuation, lag, lengthening), and hydrological drought typology (<i>classical rainfall deficit drought, rain-to-snow-season drought, wet-to-dry-season drought, cold snow season drought, warm snow season drought, composite drought</i>). <br><br> Drought characteristics simulated by large-scale models clearly reflected drought propagation; i.e. drought events became fewer and longer when moving through the hydrological cycle. However, more differentiation was expected between fast and slowly responding systems, with slowly responding systems having fewer and longer droughts in runoff than fast responding systems. This was not found using large-scale models. Drought propagation features were poorly reproduced by the large-scale models, because runoff reacted immediately to precipitation, in all case study areas. This fast reaction to precipitation, even in cold climates in winter and in semi-arid climates in summer, also greatly influenced the hydrological drought typology as identified by the large-scale models. In general, the large-scale models had the correct representation of drought types, but the percentages of occurrence had some important mismatches, e.g. an overestimation of <i>classical rainfall deficit droughts</i>, and an underestimation of <i>wet-to-dry-season droughts</i> and snow-related droughts. Furthermore, almost no <i>composite droughts</i> were simulated for slowly responding areas, while many multi-year drought events were expected in these systems. <br><br> We conclude that most drought propagation processes are reasonably well reproduced by the ensemble mean of large-scale models in contrasting catchments in Europe. Challenges, however, remain in catchments with cold and semi-arid climates and catchments with large storage in aquifers or lakes. This leads to a high uncertainty in hydrological drought simulation at large scales. Improvement of drought simulation in large-scale models should focus on a better representation of hydrological processes that are important for drought development, such as evapotranspiration, snow accumulation and melt, and especially storage. Besides the more explicit inclusion of storage in large-scale models, also parametrisation of storage processes requires attention, for example through a global-scale dataset on aquifer characteristics, improved large-scale datasets on other land characteristics (e.g. soils, land cover), and calibration/evaluation of the models against observations of storage (e.g. in snow, groundwater)
Three-micron spectra of AGB stars and supergiants in nearby galaxies
The dependence of stellar molecular bands on the metallicity is studied using
infrared L-band spectra of AGB stars (both carbon-rich and oxygen-rich) and
M-type supergiants in the Large and Small Magellanic Clouds (LMC and SMC) and
in the Sagittarius Dwarf Spheroidal Galaxy. The spectra cover SiO bands for
oxygen-rich stars, and acetylene (C2H2), CH and HCN bands for carbon-rich AGB
stars. The equivalent width of acetylene is found to be high even at low
metallicity. The high C2H2 abundance can be explained with a high
carbon-to-oxygen (C/O) ratio for lower metallicity carbon stars. In contrast,
the HCN equivalent width is low: fewer than half of the extra-galactic carbon
stars show the 3.5micron HCN band, and only a few LMC stars show high HCN
equivalent width. HCN abundances are limited by both nitrogen and carbon
elemental abundances. The amount of synthesized nitrogen depends on the initial
mass, and stars with high luminosity (i.e. high initial mass) could have a high
HCN abundance. CH bands are found in both the extra-galactic and Galactic
carbon stars. None of the oxygen-rich LMC stars show SiO bands, except one
possible detection in a low quality spectrum. The limits on the equivalent
widths of the SiO bands are below the expectation of up to 30angstrom for LMC
metallicity. Several possible explanations are discussed. The observations
imply that LMC and SMC carbon stars could reach mass-loss rates as high as
their Galactic counterparts, because there are more carbon atoms available and
more carbonaceous dust can be formed. On the other hand, the lack of SiO
suggests less dust and lower mass-loss rates in low-metallicity oxygen-rich
stars. The effect on the ISM dust enrichment is discussed.Comment: accepted for A&
A Spitzer IRAC Census of the Asymptotic Giant Branch Populations in Local Group Dwarfs. II. IC 1613
We present Spitzer Space Telescope IRAC photometry of the Local Group dwarf
irregular galaxy IC 1613. We compare our 3.6, 4.5, 5.8, and 8.0 micron
photometry with broadband optical photometry and find that the optical data do
not detect 43% and misidentify an additional 11% of the total AGB population,
likely because of extinction caused by circumstellar material. Further, we find
that a narrowband optical carbon star study of IC 1613 detects 50% of the total
AGB population and only considers 18% of this population in calculating the
carbon to M-type AGB ratio. We derive an integrated mass-loss rate from the AGB
stars of 0.2-1.0 x 10^(-3) solar masses per year and find that the distribution
of bolometric luminosities and mass-loss rates are consistent with those for
other nearby metal-poor galaxies. Both the optical completeness fractions and
mass-loss rates in IC 1613 are very similar to those in the Local Group dwarf
irregular, WLM, which is expected given their similar characteristics and
evolutionary histories.Comment: Accepted by ApJ, 26 pages, 10 figures, version with high-resolution
figures available at: http://webusers.astro.umn.edu/~djackson
Very Large Telescope three micron spectra of dust-enshrouded red giants in the Large Magellanic Cloud
We present ESO/VLT spectra in the 2.9--4.1 micron range for a large sample of
infrared stars in the Large Magellanic Cloud (LMC), selected on the basis of
MSX and 2MASS colours to be extremely dust-enshrouded AGB star candidates. Out
of 30 targets, 28 are positively identified as carbon stars, significantly
adding to the known population of optically invisible carbon stars in the LMC.
We also present spectra for six IR-bright stars in or near three clusters in
the LMC, identifying four of them as carbon stars and two as oxygen-rich
supergiants. We analyse the molecular bands of C2H2 at 3.1 and 3.8 micron, HCN
at 3.57 micron, and sharp absorption features in the 3.70--3.78 micron region
that we attribute to C2H2. There is evidence for a generally high abundance of
C2H2 in LMC carbon stars, suggestive of high carbon-to-oxygen abundance ratios
at the low metallicity in the LMC. The low initial metallicity is also likely
to have resulted in less abundant HCN and CS. The sample of IR carbon stars
exhibits a range in C2H2:HCN abundance ratio. We do not find strong
correlations between the properties of the molecular atmosphere and
circumstellar dust envelope, but the observed differences in the strengths and
shapes of the absorption bands can be explained by differences in excitation
temperature. High mass-loss rates and strong pulsation would then be seen to be
associated with a large scale height of the molecular atmosphere.Comment: Accepted for publication in Astronomy and Astrophysics. 20 pages.
Figure 11 is degraded for posting on astro-p
Socioeconomic status and colon cancer incidence: a prospective cohort study.
The association between socioeconomic status and colon cancer was investigated in a prospective cohort study that started in 1986 in The Netherlands among 120,852 men and women aged 55-69 years. At baseline, data on socioeconomic status, alcohol consumption and other dietary and non-dietary covariates were collected by means of a self-administered questionnaire. For data analysis a case-cohort approach was used, in which the person-years at risk were estimated using a randomly selected subcohort (1688 men and 1812 women). After 3.3 years of follow-up, 312 incident colon cancer cases were detected: 157 men and 155 women. After adjustment for age, we found a positive association between colon cancer risk and highest level of education (trend P = 0.13) and social standing (trend P = 0.008) for men. Also, male, upper white-collar workers had a higher colon cancer risk than blue-collar workers (RR = 1.42, 95% CI 0.95-2.11). Only the significant association between social standing and colon cancer risk persisted after additional adjustment for other risk factors for colon cancer (trend P = 0.005), but the higher risk was only found in the highest social standing category (RR highest/lowest social standing = 2.60, 95% CI 1.31-5.14). In women, there were no clear associations between the socioeconomic status indicators and colon cancer
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