On the critical end point in a two-flavor linear sigma model coupled to quarks

We use the linear sigma model coupled to quarks to explore the location of the phase transition lines in the QCD phase diagram from the point of view of chiral symmetry restoration at high temperature and baryon chemical potential. We compute analytically the effective potential in the high- and low-temperature approximations up to sixth order, including the contribution of the ring diagrams to account for the plasma screening properties. We determine the model parameters, namely, the couplings and mass-parameter, from conditions valid at the first order phase transition at vanishing temperature and, using the Hagedorn limiting temperature concept applied to finite baryon density, for a critical baryochemical potential of order of the nucleon mass. We show that when using the set of parameters thus determined, the second order phase transition line (our proxy for the crossover transition) that starts at finite temperature and zero baryon chemical potential converges to the line of first order phase transitions that starts at zero temperature and finite baryon chemical potential to determine the critical end point to lie in the region 5.02<\mu_B^{\mbox{CEP}}/T_c<5.18, 0.14, where $T_c$ is the critical transition temperature at zero baryon chemical potential.Comment: 11 pages, 3 figures, discussion extended, explicit calculations included in appendices and version accepted for publication in EPJ

Ion channels and neuronal excitability in polyglutamine neurodegenerative diseases

Abstract Polyglutamine (polyQ) diseases are a family composed of nine neurodegenerative inherited disorders (NDDs) caused by pathological expansions of cytosine-adenine-guanine (CAG) trinucleotide repeats which encode a polyQ tract in the corresponding proteins. CAG polyQ repeat expansions produce neurodegeneration via multiple downstream mechanisms; among those the neuronal activity underlying the ion channels is affected directly by specific channelopathies or indirectly by secondary dysregulation. In both cases, the altered excitability underlies to gain- or loss-of-function pathological effects. Here we summarize the repertoire of ion channels in polyQ NDDs emphasizing the biophysical features of neuronal excitability and their pathogenic role. The aim of this review is to point out the value of a deeper understanding of those functional mechanisms and processes as crucial elements for the designing and targeting of novel therapeutic avenues

Alumina-Based Composites Reinforced with Ductile Particles

Al2O3/Metal composite ceramics were fabricated by the use of mechanical milling and pressureless sintering. Al2O3 + 10 vol.% of La, Mn, Si or Y were mixed and milled during 12 h at 300 rpm in a horizontal mill, then with the powder mixture it was conformed cylindrical samples by uniaxial pressing using 300 MPa. Pressed samples were sintered during 2 h in an electrical furnace at 1500°C. During sintered it was used an argon atmosphere inside the furnace in order to inhibit metal oxidation. XRD results indicate that alumina and metals retain its crystalline structure. Reached density by samples is small and less than 90%. Scanning electron microscopy observations show alumina’s microstructure with very fine and homogeneous distributions of metal particles. Both the Mn and Si are not suitable metals to improve the mechanical properties of alumina, in particular the fracture toughness. Considered rare earth metals such as yttrium and lanthanum, have yielded favorable results in improving the fracture toughness of the alumina. However, it should be made more dense materials with them to better explore this potential