Securitization and Community-Based Protection Among Chin Refugees in Kuala Lumpur

This article examines refugee-led community organizations among Chin refugees from Myanmar in Kuala Lumpur. It uses a structuration analysis that recognizes refugee-led organizations as complex governance entities engaged in a dynamic relationship with (among others) national policies of securitization of forced migration and international humanitarian governance. This approach expands the existing literature on the securitization of forced migration by exploring refugees’ lived experiences in a context of south–south migration. It expands the literature on community-based protection by going beyond recognizing the existence of refugee-led organizations to analyse their construction, constitution and consequences. Three primary areas of work by Chin refugee groups are analysed in relation to their immediate activity and longer term effects: organization (‘building ethnic unity in adversity’), documentation (‘asserting a bureaucratic identity’) and socialization (‘learning to be illegal’). These long-term effects indicate the possible impact of local protection activities on macrostructural processes such as identity construction and migration choices.construction, constitution and consequences. Three primary areas of work by Chin refugee groups are analysed in relation to their immediate activity and longer term effects: organization (‘building ethnic unity in adversity’), documentation (‘asserting a bureaucratic identity’) and socialization (‘learning to be illegal’). These long-term effects indicate the possible impact of local protection activities on macrostructural processes such as identity construction and migration choices

Immunotherapy with allotumour mRNA-transfected dendritic cells in androgen-resistant prostate cancer patients

Here, we present results from a clinical trial employing a new vaccination method using dendritic cells (DCs) transfected with mRNA from allogeneic prostate cancer cell lines (DU145, LNCaP and PC-3). In all, 20 patients were enrolled and 19 have completed vaccination. Each patient received at least four weekly injections with 2 × 107 transfected DCs either intranodally or intradermally. Safety and feasibility of vaccination were determined. Immune responses were measured as delayed-type hypersensitivity and by in vitro immunoassays including ELISPOT and T-cell proliferation in pre- and postvaccination peripheral blood samples. Serum prostate-specific antigen (PSA) levels and bone scans were monitored. No toxicity or serious adverse events related to vaccinations were observed. A total of 12 patients developed a specific immune response to tumour mRNA-transfected DCs. In total, 13 patients showed a decrease in log slope PSA. This effect was strengthened by booster vaccinations. Clinical outcome was significantly related to immune responses (n=19, P=0.002, r=0.68). Vaccination with mRNA-transfected DCs is safe and results in cellular immune responses specific for antigens encoded by mRNA derived from the prostate cancer cell lines. The observation that in some patients vaccination affected the PSA level suggests that this approach may become useful as a treatment modality for prostate cancer patients

A precise bathymetric map of the world’s deepest seafloor, Challenger Deep in the Mariana Trench

Data from three bathymetric surveys by R/V Kairei using a 12-kHz multibeam echosounder and differential GPS were used to create an improved topographic model of the Challenger Deep in the southwestern part of the Mariana Trench, which is known as the deepest seafloor in the world. The strike of most of the elongated structures related to plate bending accompanied by subduction of the Pacific plate is N70°E and is not parallel to the trench axis. The bending-related structures were formed by reactivation of seafloor spreading fabric. Challenger Deep consists of three en echelon depressions along the trench axis, each of which is 6-10 km long, about 2 km wide, and deeper than 10,850 m. The eastern depression is the deepest, with a depth of 10,920 ± 5 m

Comparison of Pallidal and Subthalamic Nucleus Deep Brain Stimulation for Advanced Parkinson’s Disease: Results of a Randomized,

OBJECTIVE: Deep brain stimulation (DBS) of the globus pallidus internus (GPi A larger study is needed to investigate further the differences in symptom response and the interaction of L-dopa with stimulation at either site. (Neurosurgery 45:1375(Neurosurgery 45: -1384(Neurosurgery 45: , 199