299 research outputs found
The modelling of the solar upper photosphere and lower chromosphere based upon ATM data
Spectral data obtained by the SO82B experiment aboard SKYLAB were used to critically evaluate existing models of the solar upper photosphere and lower chromosphere. These spectral diagnostics were used to develop new solar models
The properties of highly luminous IRAS galaxies
From a complete sample of 154 galaxies identified with IRAS sources in a 304 sq deg area centered on the South Galactic Pole, a subsample of 58 galaxies with L sub IR/L sub B > 3 was chosen. Low resolution spectra were obtained for 30% of the subsample and redshifts and relative emission line intensities were derived. As a class these galaxies are very luminous with = 2.9 x 10 to the 11th power L sub 0 and (L sub IR) max = 1.3 x 10 to the 12th power L sub 0. CCD images and JHK photometry were obtained for many of the subsample. The galaxies are for the most part newly identified and are optically faint, with a majority showing evidence of a recent interaction. Radio continuum observations of all galaxies of the subsample were recently obtained at 20 cm VLA with about 75% being detected in a typical integration time of about 10 minutes
Rapidly Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in NSCLC Cell Lines through De-Repression of FGFR2 and FGFR3 Expression
Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs, nearly all will develop resistance and relapse. Gene expression analysis of NSCLC cell lines treated with the EGFR TKI, gefitinib, revealed increased levels of FGFR2 and FGFR3 mRNA. Analysis of gefitinib action on a larger panel of NSCLC cell lines verified that FGFR2 and FGFR3 expression is increased at the mRNA and protein level in NSCLC cell lines in which the EGFR is dominant for growth signaling, but not in cell lines where EGFR signaling is absent. A luciferase reporter containing 2.5 kilobases of fgfr2 5′ flanking sequence was activated after gefitinib treatment, indicating transcriptional regulation as a contributing mechanism controlling increased FGFR2 expression. Induction of FGFR2 and FGFR3 protein as well as fgfr2-luc activity was also observed with Erbitux, an EGFR-specific monoclonal antibody. Moreover, inhibitors of c-Src and MEK stimulated fgfr2-luc activity to a similar degree as gefitinib, suggesting that these pathways may mediate EGFR-dependent repression of FGFR2 and FGFR3. Importantly, our studies demonstrate that EGFR TKI-induced FGFR2 and FGFR3 are capable of mediating FGF2 and FGF7 stimulated ERK activation as well as FGF-stimulated transformed growth in the setting of EGFR TKIs. In conclusion, this study highlights EGFR TKI-induced FGFR2 and FGFR3 signaling as a novel and rapid mechanism of acquired resistance to EGFR TKIs and suggests that treatment of NSCLC patients with combinations of EGFR and FGFR specific TKIs may be a strategy to enhance efficacy of single EGFR inhibitors
The XO Project: Searching for Transiting Extra-solar Planet Candidates
The XO project's first objective is to find hot Jupiters transiting bright
stars, i.e. V < 12, by precision differential photometry. Two XO cameras have
been operating since September 2003 on the 10,000-foot Haleakala summit on
Maui. Each XO camera consists of a 200-mm f/1.8 lens coupled to a 1024x1024
pixel, thinned CCD operated by drift scanning. In its first year of routine
operation, XO has observed 6.6% of the sky, within six 7 deg-wide strips
scanned from 0 deg to +63 deg of declination and centered at RA=0, 4, 8, 12,
16, and 20 hours. Autonomously operating, XO records 1 billion pixels per clear
night, calibrates them photometrically and astrometrically, performs aperture
photometry, archives the pixel data and transmits the photometric data to STScI
for further analysis. From the first year of operation, the resulting database
consists of photometry of 100,000 stars at more than 1000 epochs per star with
differential photometric precision better than 1% per epoch. Analysis of the
light curves of those stars produces transiting-planet candidates requiring
detailed follow up, described elsewhere, culminating in spectroscopy to measure
radial-velocity variation in order to differentiate genuine planets from the
more numerous impostors, primarily eclipsing binary and multiple stars.Comment: 29 pages, 12 figures, accepted by PASP for Aug 2005 issu
Integrating network topology metrics into studies of catchment-level effects on river characteristics
The spatial arrangement of the river network is a fundamental
characteristic of the catchment, acting as a conduit between catchment-level
effects and reach morphology and ecology. Yet river network structure is
often simplified to reflect an upstream-to-downstream gradient of river
characteristics, commonly represented by stream order. The aim of this study
is to quantify network topological structure using two network density
metrics – one that represents network density over distance and the other
over elevation – that can easily be extracted from digital elevation models
and so may be applied to any catchment across the globe. These metrics should
better account for the multi-dimensional nature of the catchment than stream
order and be functionally applicable across geomorphological, hydrological
and ecological attributes of the catchment. The functional utility of the
metrics is assessed by appropriating monitoring data collected for regulatory
compliance to explore patterns of river characteristics in relation to
network topology. This method is applied to four comparatively low-energy,
anthropogenically modified catchments in the UK using river characteristics
derived from England's River Habitat Survey database. The patterns in river
characteristics explained by network density metrics are compared to stream
order as a standard measure of topology. The results indicate that the
network density metrics offer a richer and functionally more relevant
description of network topology than stream order, highlighting differences
in the density and spatial arrangement of each catchment's internal network
structure. Correlations between the network density metrics and river
characteristics show that habitat quality score consistently increases with
network density in all catchments as hypothesized.
For other measures of river character – modification score, flow-type speed and sediment size – there are varying
responses in different catchments to the two network density metrics. There
are few significant correlations between stream order and the river
characteristics, highlighting the limitations of stream order in accounting
for network topology. Overall, the results suggest that network density
metrics are more powerful measures which conceptually and functionally
provide an improved method of accounting for the impacts of network topology
on the fluvial system.</p
A Transiting Planet of a Sun-like Star
A planet transits an 11th magnitude, G1V star in the constellation Corona
Borealis. We designate the planet XO-1b, and the star, XO-1, also known as GSC
02041-01657. XO-1 lacks a trigonometric distance; we estimate it to be 200+-20
pc. Of the ten stars currently known to host extrasolar transiting planets, the
star XO-1 is the most similar to the Sun in its physical characteristics: its
radius is 1.0+-0.08 R_Sun, its mass is 1.0+-0.03 M_Sun, V sini < 3 km/s, and
its metallicity [Fe/H] is 0.015+-0.04. The orbital period of the planet XO-1b
is 3.941534+-0.000027 days, one of the longer ones known. The planetary mass is
0.90+-0.07 M_Jupiter, which is marginally larger than that of other transiting
planets with periods between 3 and 4 days. Both the planetary radius and the
inclination are functions of the spectroscopically determined stellar radius.
If the stellar radius is 1.0+-0.08 R_Sun, then the planetary radius is
1.30+-0.11 R_Jupiter and the inclination of the orbit is 87.7+-1.2 degrees. We
have demonstrated a productive international collaboration between professional
and amateur astronomers that was important to distinguishing this planet from
many other similar candidates.Comment: 31 pages, 9 figures, accepted for part 1 of Ap
XO-3b: A Massive Planet in an Eccentric Orbit Transiting an F5V Star
We report the discovery of a massive (Mpsini = 13.02 +/- 0.64 Mjup; total
mass 13.25 +/- 0.64 Mjup), large (1.95 +/- 0.16 Rjup) planet in a transiting,
eccentric orbit (e = 0.260 +/- 0.017) around a 10th magnitude F5V star in the
constellation Camelopardalis. We designate the planet XO-3b, and the star XO-3,
also known as GSC 03727-01064. The orbital period of XO-3b is 3.1915426 +/-
0.00014 days. XO-3 lacks a trigonometric distance; we estimate its distance to
be 260 +/- 23 pc. The radius of XO-3 is 2.13 +/- 0.21 Rsun, its mass is 1.41
+/- 0.08 Msun, its vsini = 18.54 +/- 0.17 km/s, and its metallicity is [Fe/H] =
-0.177 +/- 0.027. This system is unusual for a number of reasons. XO-3b is one
of the most massive planets discovered around any star for which the orbital
period is less than 10 days. The mass is near the deuterium burning limit of 13
Mjup, which is a proposed boundary between planets and brown dwarfs. Although
Burrows et al. (2001) propose that formation in a disk or formation in the
interstellar medium in a manner similar to stars is a more logical way to
differentiate planets and brown dwarfs, our current observations are not
adequate to address this distinction. XO-3b is also unusual in that its
eccentricity is large given its relatively short orbital period. Both the
planetary radius and the inclination are functions of the spectroscopically
determined stellar radius. Analysis of the transit light curve of XO-3b
suggests that the spectroscopically derived parameters may be over estimated.
Though relatively noisy, the light curves favor a smaller radius in order to
better match the steepness of the ingress and egress. The light curve fits
imply a planetary radius of 1.25 +/- 0.15 Rjup, which would correspond to a
mass of 12.03 +/- 0.46 Mjup.Comment: 26 pages, 10 figures. Accepted by ApJ. Current version has several
small corrections as a result of a bug in the fitting softwar
XO-2b: Transiting Hot Jupiter in a Metal-rich Common Proper Motion Binary
We report on a V=11.2 early K dwarf, XO-2 (GSC 03413-00005), that hosts a
Rp=0.98+0.03/-0.01 Rjup, Mp=0.57+/-0.06 Mjup transiting extrasolar planet,
XO-2b, with an orbital period of 2.615857+/-0.000005 days. XO-2 has high
metallicity, [Fe/H]=0.45+/-0.02, high proper motion, mu_tot=157 mas/yr, and has
a common proper motion stellar companion with 31" separation. The two stars are
nearly identical twins, with very similar spectra and apparent magnitudes. Due
to the high metallicity, these early K dwarf stars have a mass and radius close
to solar, Ms=0.98+/-0.02 Msolar and Rs=0.97+0.02/-0.01 Rsolar. The high proper
motion of XO-2 results from an eccentric orbit (Galactic pericenter, Rper<4
kpc) well confined to the Galactic disk (Zmax~100 pc). In addition, the phase
space position of XO-2 is near the Hercules dynamical stream, which points to
an origin of XO-2 in the metal-rich, inner Thin Disk and subsequent dynamical
scattering into the solar neighborhood. We describe an efficient Markov Chain
Monte Carlo algorithm for calculating the Bayesian posterior probability of the
system parameters from a transit light curve.Comment: 14 pages, 10 Figures, Accepted in ApJ. Negligible changes to XO-2
system properties. Removed Chi^2 light curve analysis section, and simplified
MCMC light curve analysis discussio
Reversal-free CaIIH profiles: a challenge for solar chromosphere modeling in quiet inter-network
We study chromospheric emission to understand the temperature stratification
in the solar chromosphere. We observed the intensity profile of the CaIIH line
in a quiet Sun region close to the disk center at the German Vacuum Tower
Telescope. We analyze over 10^5 line profiles from inter-network regions. For
comparison with the observed profiles, we synthesize spectra for a variety of
model atmospheres with a non local thermodynamic equilibrium (NLTE) radiative
transfer code. A fraction of about 25% of the observed CaIIH line profiles do
not show a measurable emission peak in H_{2v} and H_{2r} wavelength bands
(reversal-free). All of the chosen model atmospheres with a temperature rise
fail to reproduce such profiles. On the other hand, the synthetic calcium
profile of a model atmosphere that has a monotonic decline of the temperature
with height shows a reversal-free profile that has much lower intensities than
any observed line profile. The observed reversal-free profiles indicate the
existence of cool patches in the interior of chromospheric network cells, at
least for short time intervals. Our finding is not only in conflict with a
full-time hot chromosphere, but also with a very cool chromosphere as found in
some dynamic simulations.Comment: 8 pages, accepted in A&
The IRAS galaxy 0421 + 040P06 - an active spiral (?) galaxy with extended radio lobes
The infrared bright galaxy 0421 + 040P06 detected by IRAS at 25 and 60 μm has been studied at optical, infrared, and radio wavelengths. It is a luminous galaxy with apparent spiral structure emitting 4 x 10^(37) W (1 x 10^(11) L_☉) from far-infrared to optical wavelengths, assuming H_0 = 75 km s^(-1) Mpc^(-1). Optical spectroscopy reveals a Seyfert 2 emission-line spectrum, making 0421 +040P06 the first active galaxy selected from an unbiased infrared survey of galaxies. The fact that this galaxy shows a flatter energy distribution with more 25 μm emission than other galaxies in the infrared sample may be related to the presence of an intense active nucleus. The radio observations reveal the presence of a nonthermal source that, at 6 cm, shows a prominent double lobed structure 20-30 kpc in size extending beyond the optical confines of the galaxy. The radio source is 3-10 times larger than structures previously seen in spiral galaxies and may represent a transition between the relatively small, weak sources seen in some active spirals and the stronger, larger ones seen toward elliptical galaxies with active nuclei
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