2,273 research outputs found
Pruning Algorithms for Pretropisms of Newton Polytopes
Pretropisms are candidates for the leading exponents of Puiseux series that
represent solutions of polynomial systems. To find pretropisms, we propose an
exact gift wrapping algorithm to prune the tree of edges of a tuple of Newton
polytopes. We prefer exact arithmetic not only because of the exact input and
the degrees of the output, but because of the often unpredictable growth of the
coordinates in the face normals, even for polytopes in generic position. We
provide experimental results with our preliminary implementation in Sage that
compare favorably with the pruning method that relies only on cone
intersections.Comment: exact, gift wrapping, Newton polytope, pretropism, tree pruning,
accepted for presentation at Computer Algebra in Scientific Computing, CASC
201
Importance of site of infection and antibiotic selection in the treatment of carbapenem-resistant Pseudomonas aeruginosa sepsis
ABSTRACT
In a retrospective analysis of 215 patients with carbapenem-resistant
Pseudomonas aeruginosa
sepsis, we observed a significantly higher risk of mortality associated with respiratory tract infection (risk ratio [RR], 1.20; 95% confidence interval [CI], 1.04 to 1.39;
P
= 0.010) and lower risk with urinary tract infection (RR, 0.80; 95% CI, 0.71 to 0.90;
P
= 0.004). Aminoglycoside monotherapy was associated with increased mortality, even after adjusting for confounders (adjusted RR, 1.72; 95% CI, 1.03 to 2.85;
P
= 0.037), consistent across multiple sites of infection.
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Relative Equilibria in the Four-Vortex Problem with Two Pairs of Equal Vorticities
We examine in detail the relative equilibria in the four-vortex problem where
two pairs of vortices have equal strength, that is, \Gamma_1 = \Gamma_2 = 1 and
\Gamma_3 = \Gamma_4 = m where m is a nonzero real parameter. One main result is
that for m > 0, the convex configurations all contain a line of symmetry,
forming a rhombus or an isosceles trapezoid. The rhombus solutions exist for
all m but the isosceles trapezoid case exists only when m is positive. In fact,
there exist asymmetric convex configurations when m < 0. In contrast to the
Newtonian four-body problem with two equal pairs of masses, where the symmetry
of all convex central configurations is unproven, the equations in the vortex
case are easier to handle, allowing for a complete classification of all
solutions. Precise counts on the number and type of solutions (equivalence
classes) for different values of m, as well as a description of some of the
bifurcations that occur, are provided. Our techniques involve a combination of
analysis and modern and computational algebraic geometry
Feature integration in natural language concepts
Two experiments measured the joint influence of three key sets of semantic features on the frequency with which artifacts (Experiment 1) or plants and creatures (Experiment 2) were categorized in familiar categories. For artifacts, current function outweighed both originally intended function and current appearance. For biological kinds, appearance and behavior, an inner biological function, and appearance and behavior of offspring all had similarly strong effects on categorization. The data were analyzed to determine whether an independent cue model or an interactive model best accounted for how the effects of the three feature sets combined. Feature integration was found to be additive for artifacts but interactive for biological kinds. In keeping with this, membership in contrasting artifact categories tended to be superadditive, indicating overlapping categories, whereas for biological kinds, it was subadditive, indicating conceptual gaps between categories. It is argued that the results underline a key domain difference between artifact and biological concepts
Gradient Clogging in Depth Filtration
We investigate clogging in depth filtration, in which a dirty fluid is
``cleaned'' by the trapping of dirt particles within the pore space during flow
through a porous medium. This leads to a gradient percolation process which
exhibits a power law distribution for the density of trapped particles at
downstream distance x from the input. To achieve a non-pathological clogging
(percolation) threshold, the system length L should scale no faster than a
power of ln w, where w is the width. Non-trivial behavior for the permeability
arises only in this extreme anisotropic geometry.Comment: 4 pages, 3 figures, RevTe
Prevalence of Streptococci and Increased Polymicrobial Diversity Associated with Cystic Fibrosis Patient Stability
Diverse microbial communities chronically colonize the lungs of cystic fibrosis patients. Pyrosequencing of amplicons for hypervariable regions in the 16S rRNA gene generated taxonomic profiles of bacterial communities for sputum genomic DNA samples from 22 patients during a state of clinical stability (outpatients) and 13 patients during acute exacerbation (inpatients). We employed quantitative PCR (qPCR) to confirm the detection of Pseudomonas aeruginosa and Streptococcus by the pyrosequencing data and human oral microbe identification microarray (HOMIM) analysis to determine the species of the streptococci identified by pyrosequencing. We show that outpatient sputum samples have significantly higher bacterial diversity than inpatients, but maintenance treatment with tobramycin did not impact overall diversity. Contrary to the current dogma in the field that Pseudomonas aeruginosa is the dominant organism in the majority of cystic fibrosis patients, Pseudomonas constituted the predominant genera in only half the patient samples analyzed and reported here. The increased fractional representation of Streptococcus in the outpatient cohort relative to the inpatient cohort was the strongest predictor of clinically stable lung disease. The most prevalent streptococci included species typically associated with the oral cavity (Streptococcus salivarius and Streptococcus parasanguis) and the Streptococcus milleri group species. These species of Streptococcus may play an important role in increasing the diversity of the cystic fibrosis lung environment and promoting patient stability
Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma.
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a disease of unmet medical need. While immunotherapy with chimeric antigen receptor T (CAR-T) cells has shown much promise in haematological malignancies, their efficacy for solid tumours is challenged by the lack of tumour-specific antigens required to avoid on-target, off-tumour effects. Switchable CAR-T cells whereby activity of the CAR-T cell is controlled by dosage of a tumour antigen-specific recombinant Fab-based 'switch' to afford a fully tunable response may overcome this translational barrier. DESIGN: In this present study, we have used conventional and switchable CAR-T cells to target the antigen HER2, which is upregulated on tumour cells, but also present at low levels on normal human tissue. We used patient-derived xenograft models derived from patients with stage IV PDAC that mimic the most aggressive features of PDAC, including severe liver and lung metastases. RESULTS: Switchable CAR-T cells followed by administration of the switch directed against human epidermal growth factor receptor 2 (HER2)-induced complete remission in difficult-to-treat, patient-derived advanced pancreatic tumour models. Switchable HER2 CAR-T cells were as effective as conventional HER2 CAR-T cells in vivo testing a range of different CAR-T cell doses. CONCLUSION: These results suggest that a switchable CAR-T system is efficacious against aggressive and disseminated tumours derived from patients with advanced PDAC while affording the potential safety of a control switch
Sounding rocket study of two sequential auroral poleward boundary intensifications
The Cascades-2 sounding rocket was launched on 20 March 2009 at 11:04:00 UT from the Poker Flat Research Range in Alaska, and flew across a series of poleward boundary intensifications (PBIs). The rocket initially crosses a diffuse arc, then crosses the equatorward extent of one PBI (a streamer), and finally crosses the initiation of a separate PBI before entering the polar cap. Each of the crossings have fundamentally different in situ electron energy and pitch angle structure, and different ground optics images of visible aurora. It is found that the diffuse arc has a quasi-static acceleration mechanism, and the intensification at the poleward boundary has an Alfvénic acceleration mechanism. The streamer shows characteristics of both types of acceleration. PFISR data provide ionospheric context for the rocket observations. Three THEMIS satellites in close conjunction with the rocket foot point show earthward flows and slight dipolarizations in the magnetotail associated with the in situ observations of PBI activity. An important goal of the Cascades-2 study is to bring together the different observational communities (rocket, ground cameras, ground radar, satellite) with the same case study. The Cascades-2 experiment is the first sounding rocket observation of a PBI sequence, enabling a detailed investigation of the electron signatures and optical aurora associated with various stages of a PBI sequence as it evolves from an Alfvénic to a more quasi-static structure
Quantum Aspects of Semantic Analysis and Symbolic Artificial Intelligence
Modern approaches to semanic analysis if reformulated as Hilbert-space
problems reveal formal structures known from quantum mechanics. Similar
situation is found in distributed representations of cognitive structures
developed for the purposes of neural networks. We take a closer look at
similarites and differences between the above two fields and quantum
information theory.Comment: version accepted in J. Phys. A (Letter to the Editor
Quantum Particles as Conceptual Entities: A Possible Explanatory Framework for Quantum Theory
We put forward a possible new interpretation and explanatory framework for
quantum theory. The basic hypothesis underlying this new framework is that
quantum particles are conceptual entities. More concretely, we propose that
quantum particles interact with ordinary matter, nuclei, atoms, molecules,
macroscopic material entities, measuring apparatuses, ..., in a similar way to
how human concepts interact with memory structures, human minds or artificial
memories. We analyze the most characteristic aspects of quantum theory, i.e.
entanglement and non-locality, interference and superposition, identity and
individuality in the light of this new interpretation, and we put forward a
specific explanation and understanding of these aspects. The basic hypothesis
of our framework gives rise in a natural way to a Heisenberg uncertainty
principle which introduces an understanding of the general situation of 'the
one and the many' in quantum physics. A specific view on macro and micro
different from the common one follows from the basic hypothesis and leads to an
analysis of Schrodinger's Cat paradox and the measurement problem different
from the existing ones. We reflect about the influence of this new quantum
interpretation and explanatory framework on the global nature and evolutionary
aspects of the world and human worldviews, and point out potential explanations
for specific situations, such as the generation problem in particle physics,
the confinement of quarks and the existence of dark matter.Comment: 45 pages, 10 figure
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