Potential For Power: A Symposium On The Prospects For Power From Currently Unconventional Energy Sources

The wave energy arriving on the west coast of the United Kingdom represents a very substantial energy resource, amounting on average to more than twice the present installed capacity of the CEGB. Recent, comprehensive, studies by the CEGB (1) (2) and the National Engineering Laboratory (3) suggest that although there is no obvious technical reason for being unable ultimately to harness much of this energy, and many methods have been proposed, there are still considerable uncertainties over the choice of wave power system and its economics. Wave power does show sufficient promise however to have been made the subject of serious studies supported by the CEGB and the Department of Energy (4). In this Paper the potential of wave power and some of the more promising methods of harnessing it are discussed, together with an appreciation of some of the many technical and engineering problems which still need to be examined, and a discussion of the impact of wave power on the environment. By considering the results of recent research and their impact on wave power economics it is argued that wave power could be exploited to conserve fossil fuels but is unlikely to be competitive with nuclear power

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a single missense mutation, Mlkl(D139V), that alters the two-helix 'brace' that connects the killer four-helix bundle and regulatory pseudokinase domains. This confers constitutive, RIPK3 independent killing activity to MLKL. Homozygous mutant mice develop lethal postnatal inflammation of the salivary glands and mediastinum. The normal embryonic development of Mlkl(D139V) homozygotes until birth, and the absence of any overt phenotype in heterozygotes provides important in vivo precedent for the capacity of cells to clear activated MLKL. These observations offer an important insight into the potential disease-modulating roles of three common human MLKL polymorphisms that encode amino acid substitutions within or adjacent to the brace region. Compound heterozygosity of these variants is found at up to 12-fold the expected frequency in patients that suffer from a pediatric autoinflammatory disease, chronic recurrent multifocal osteomyelitis (CRMO). Necroptosis is a regulated form of inflammatory cell death driven by activated MLKL. Here, the authors identify a mutation in the brace region that confers constitutive activation, leading to lethal inflammation in homozygous mutant mice and providing insight into human mutations in this region

Amendment to educational agreement with Thailand, foreign service despatch no. 437

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The European HDR project at Soultz sous forets: Stimulation of the second deep well and first circulation experiments

By February 1995 the European HDR project at Soultz was operating 6 boreholes: 2 deep hydraulic test wells (GPK-1, 3590 m & GPK-2, 3876 m) and 4 seismic observation wells with depths between 1500 and 2200 m. In 1993 the first section of a deep underground exchanger had been created through massive stimulation (injection of some 45000 m³ of water). Between November 1994 until January 1995 a second deep well, GPK-2, was drilled at the periphery of this exchanger. A complex test programme involving the stimulation of GPK-2 (connecting it to the existing exchanger) and various circulation experiments with different production techniques (flash throttled and unthrottled, submersible pump) and varying injection rates was performed between June and August 1995

The physiological effects of restrictive environmental conditions on Dictyostelium discoideum spore germination

Spores may be reversibly activated by the application of heat, dimethyl sulfoxide, urea, or ethylene glucol. Severe changes in four environmental variables (high osmotic pressure, low oxygen tension, low or high pH, and low or high temperature) interfere with the germination process. Spores at the end of the postactivation lag phase of germination were usually deactivated if exposed to severe environmental conditions and thus did not swell; spores in the swelling and emergence stages of germination were killed if exposed to severe environmental conditions. The oxygen uptake which began during spore activation was primarily attributable to a cyanide-sensitive pathway and secondarily to a salicylhydroxamic acid (SHAM) sensitive pathway. Inhibition of the SHAM-sensitive pathway did not cause spore deactivation while the addition of cyanide resulted in rapid spore deactivation. Treatment of activated spores with azide or environmental shifts also resulted in inhibition of oxygen uptake and spore deactivation. Deactivating spores did not demonstrate the amino acid incorporation, uridine incorporation, and expression of trehalase activity which is found in the later stages of germinating control spores. Protein synthesis inhibitors did not cause spore deactivation or a decrease in oxygen uptake but they inhibited amino acid incorporation and the expression of trehalase activity in swollen spores. It is concluded that control of respiratory activity is involved in regulation of reversible activation