A Simple Calculus for Discrete Systems, Part B

Mathematical model for man machine development cycle

Reflections on a Measurement of the Gravitational Constant Using a Beam Balance and 13 Tons of Mercury

In 2006, a final result of a measurement of the gravitational constant $G$ performed by researchers at the University of Z\"urich was published. A value of G=6.674\,252(122)\times 10^{-11}\,\mbox{m}^3\,\mbox{kg}^{-1}\,\mbox{s}^{-2} was obtained after an experimental effort that lasted over one decade. Here, we briefly summarize the measurement and discuss the strengths and weaknesses of this approach.Comment: 13 pages, 5 figures accepted for publication in Phil. Trans. R. Soc.

Morus rubra L.

https://thekeep.eiu.edu/herbarium_specimens_byname/20058/thumbnail.jp

Morus rubra L.

https://thekeep.eiu.edu/herbarium_specimens_byname/20058/thumbnail.jp

Morus rubra L.

https://thekeep.eiu.edu/herbarium_specimens_byname/20048/thumbnail.jp

Maclura pomifera (Raf.) Schneid.

https://thekeep.eiu.edu/herbarium_specimens_byname/19943/thumbnail.jp

Mesothelial cells regulate immune responses in health and disease: Role for immunotherapy in malignant mesothelioma

Highlights: Mesothelial and immune cell interactions play a crucial role in tissue homeostasis in the serosal cavities such as the pleura. Mesothelin is viewed as an attractive target for solid tumors, including malignant mesothelioma. Checkpoint inhibitor therapy has shown variable efficacy against malignant mesothelioma. CAR T cell therapies are being evaluated for malignant mesothelioma. Treatment of malignant mesothelioma will require multimodality approaches with immunotherapy central to future therapeutic approaches. The mesothelium when first described was thought to function purely as a non-adhesive surface to facilitate intracoelomic movement of organs. However, the mesothelium is now recognized as a dynamic cellular membrane with many important functions that maintain serosal integrity and homeostasis. For example, mesothelial cells interact with and help regulate the body’s inflammatory and immune system following infection, injury, or malignancy. With recent advances in our understanding of checkpoint molecules and the advent of novel immunotherapy approaches, there has been an increase in the number of studies examining mesothelial and immune cell interaction, in particular the role of these interactions in malignant mesothelioma. This review will highlight some of the recent advances in our understanding of how mesothelial cells help regulate serosal immunity and how in a malignant environment, the immune system is hijacked to stimulate tumor growth. Ways to treat mesothelioma using immunotherapy approaches will also be discussed

A Measurement of Newton's Gravitational Constant

A precision measurement of the gravitational constant $G$ has been made using a beam balance. Special attention has been given to determining the calibration, the effect of a possible nonlinearity of the balance and the zero-point variation of the balance. The equipment, the measurements and the analysis are described in detail. The value obtained for G is 6.674252(109)(54) 10^{-11} m3 kg-1 s-2. The relative statistical and systematic uncertainties of this result are 16.3 10^{-6} and 8.1 10^{-6}, respectively.Comment: 26 pages, 20 figures, Accepted for publication by Phys. Rev.

Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase

Macrophages are a key component of the innate immune system. In this study, we investigate how focal adhesion kinase (FAK) and the related kinase Pyk2 integrate adhesion signaling and growth factor receptor signaling to regulate diverse macrophage functions. Primary bone marrow macrophages isolated from mice in which FAK is conditionally deleted from cells of the myeloid lineage exhibited elevated protrusive activity, altered adhesion dynamics, impaired chemotaxis, elevated basal Rac1 activity, and a marked inability to form stable lamellipodia necessary for directional locomotion. The contribution of FAK to macrophage function in vitro was substantiated in vivo by the finding that recruitment of monocytes to sites of inflammation was impaired in the absence of FAK. Decreased Pyk2 expression in primary macrophages also resulted in a diminution of invasive capacity. However, the combined loss of FAK and Pyk2 had no greater effect than the loss of either molecule alone, indicating that both kinases function within the same pathway to promote invasion

Chirality scenario of the spin-glass ordering

Detailed account is given of the chirality scenario of experimental spin-glass transitions. In this scenario, the spin glass order of weakly anisotropic Heisenberg-like spin-glass magnets including canonical spin glasses are essentially chirality driven. Recent numerical and experimental results are discussed in conjunction with this scenario.Comment: Submitted to J. Phys. Soc. Japan "Special Issue on Frustration