Chaotic Strings in AdS/CFT.

Holographic theories with classical gravity duals are maximally chaotic; i.e., they saturate the universal bound on the rate of growth of chaos [J. Maldacena, S. H. Shenker, and D. Stanford, J. High Energy Phys. 08 (2016) 106JHEPFG1029-847910.1007/JHEP08(2016)106]. It is interesting to ask whether this property is true only for leading large N correlators or if it can show up elsewhere. In this Letter, we consider the simplest setup to tackle this question: a Brownian particle coupled to a thermal ensemble. We find that the four-point out-of-time-order correlator that diagnoses chaos initially grows at an exponential rate that saturates the chaos bound, i.e., with a Lyapunov exponent λ_{L}=2π/β. However, the scrambling time is parametrically smaller than for plasma excitations, t_{*}∼βlogsqrt[λ] instead of t_{*}∼βlogN^{2}. Our result shows that, at least in certain cases, maximal chaos can be attained in the probe sector without the explicit need of gravitational degrees of freedom.Funded by SCOAP3

Controlled Irradiative Formation of Penitentes

Spike-shaped structures are produced by light-driven ablation in very different contexts. Penitentes 1-4 m high are common on Andean glaciers, where their formation changes glacier dynamics and hydrology. Laser ablation can produce cones 10-100 microns high with a variety of proposed applications in materials science. We report the first laboratory generation of centimeter-scale snow and ice penitentes. Systematically varying conditions allows identification of the essential parameters controlling the formation of ablation structures. We demonstrate that penitente initiation and coarsening requires cold temperatures, so that ablation leads to sublimation rather than melting. Once penitentes have formed, further growth of height can occur by melting. The penitentes intially appear as small structures (3 mm high) and grow by coarsening to 1-5 cm high. Our results are an important step towards understanding and controlling ablation morphologies.Comment: Accepted for publication in Physical Review Letter

Casimir force in brane worlds: coinciding results from Green's and Zeta function approaches

Casimir force encodes the structure of the field modes as vacuum fluctuations and so it is sensitive to the extra dimensions of brane worlds. Now, in flat spacetimes of arbitrary dimension the two standard approaches to the Casimir force, Green's function and zeta function, yield the same result, but for brane world models this was only assumed. In this work we show both approaches yield the same Casimir force in the case of Universal Extra Dimensions and Randall-Sundrum scenarios with one and two branes added by p compact dimensions. Essentially, the details of the mode eigenfunctions that enter the Casimir force in the Green's function approach get removed due to their orthogonality relations with a measure involving the right hyper-volume of the plates and this leaves just the contribution coming from the Zeta function approach. The present analysis corrects previous results showing a difference between the two approaches for the single brane Randall-Sundrum; this was due to an erroneous hyper-volume of the plates introduced by the authors when using the Green's function. For all the models we discuss here, the resulting Casimir force can be neatly expressed in terms of two four dimensional Casimir force contributions: one for the massless mode and the other for a tower of massive modes associated with the extra dimensions.Comment: 30 pages, title, abstract and discussion have change

Prevention of mucositis in bone marrow transplantation: A double blind randomised controlled trial of sucralfate

Mucositis is still a leading side effect of high dose chemotherapy and irradiation delivered in autologous and allogeneic bone marrow transplantation. In this double blind randomised study, we tested the efficacy of sucralfate for the prevention of mucositis induced by such conditioning treatments. Treatment was started one day before conditioning regimen and patients were prospectively evaluated. The main endpoint was severe mucositis that was more frequent in the placebo group than in the sucralfate group (47% vs. 29%, P = 0.07). This trend was confirmed after adjustment on total body irradiation (TBI) (P = 0.06), the sole stratification parameter. Interestingly, patients receiving sucralfate showed a significant reduction of diarrhoea (25% vs. 53%, P = 0.005). Overall, the preventive administration of sucralfate appears to be an effective proce dure to diminish the occurrence of severe oral and intestinal mucositis in patients treated by high dose chemotherapy alone or combined with TBI before bone marrow transplantatio

IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids

Insulin-like growth factor-II (IGF-II) is a naturally occurring hormone that exerts neurotrophic and neuroprotective properties in a wide range of neurodegenerative diseases and ageing. Accumulating evidence suggests that the effects of IGF-II in the brain may be explained by its binding to the specific transmembrane receptor, IGFII/M6P receptor (IGF-IIR). However, relatively little is known regarding the role of IGF-II through IGF-IIR in neuroprotection. Here, using adult cortical neuronal cultures, we investigated whether IGF-II exhibits long-term antioxidant effects and neuroprotection at the synaptic level after oxidative damage induced by high and transient levels of corticosterone (CORT). Furthermore, the involvement of the IGF-IIR was also studied to elucidate its role in the neuroprotective actions of IGF-II. We found that neurons treated with IGF-II after CORT incubation showed reduced oxidative stress damage and recovered antioxidant status (normalized total antioxidant status, lipid hydroperoxides and NAD(P) H:quinone oxidoreductase activity). Similar results were obtained when mitochondria function was analysed (cytochrome c oxidase activity, mitochondrial membrane potential and subcellular mitochondrial distribution). Furthermore, neuronal impairment and degeneration were also assessed (synaptophysin and PSD-95 expression, presynaptic function and FluoroJade B® stain). IGF-II was also able to recover the long-lasting neuronal cell damage. Finally, the effects of IGF-II were not blocked by an IGF-IR antagonist, suggesting the involvement of IGF-IIR. Altogether these results suggest that, in or model, IGF-II through IGF-IIR is able to revert the oxidative damage induced by CORT. In accordance with the neuroprotective role of the IGF-II/IGF-IIR reported in our study, pharmacotherapy approaches targeting this pathway may be useful for the treatment of diseases associated with cognitive deficits (i.e., neurodegenerative disorders, depression, etc.)

Model Comparison to Interpret the Kinetics of in vitroGas Production with Bovine Excreta Used as Inoculum.

New models to help interpret the kinetics of in vitrogas production with bovine excreta used as inoculum were suggested. Samples of L. leucocephala, G. sepiumand P. maximum, with different gas production profiles, were used. The samples were submitted to the procedure for gas production and the volumes were determined every 3 h, in the first 30 h; then at 36; 48; 72 and 96 h. Five models were compared (two monophase and three biphase), and the parameters for better adjustment were determined. Mean squared error and the Durbin-Watson test were used as comparison criteria. It was concluded that the monophase models fall short to describe the kinetics of in vitrogas production with bovine excreta; whereas the biphase models with simple exponential components are useful. The biphase equation, where V = 0 for t < L and V = B * (1 – EXP (- C * (t - L))) for t ≥L classified as the most useful work is done with syringes

Silicon-Rich Oxide Obtained by Low-Pressure Chemical Vapor Deposition to Develop Silicon Light Sources

Off stoichiometric silicon oxide, also known as silicon-rich oxide (SRO), is a light-emitting material that is compatible with silicon technology; therefore, it is a good candidate to be used as a light source in all-silicon optoelectronic circuits. The SRO obtained by low-pressure chemical vapor deposition (LPCVD) has shown the best luminescent properties compared to other techniques. In spite of LPCVD being a simple technique, it is not a simple task to obtain SRO with exact silicon excess in a reliable and repetitive way. In this work, the expertise obtained in our group to obtain SRO by LPCVD with precise variation is presented. Also, the characteristics of this SRO obtained in our group are revised and discussed. It is demonstrated that LPCVD is an excellent technique to obtain single layers and multilayers of nanometric single layers with good characteristics