Developmental Principles: Fact or Fiction

While still at school, most of us are deeply impressed by the underlying principles that so beautifully explain why the chemical elements are ordered as they are in the periodic table, and may wonder, with the theoretician Brian Goodwin, “whether there might be equally powerful principles that account for the awe-inspiring diversity of body forms in the living realm”. We have considered the arguments for developmental principles, conclude that they do exist and have specifically identified features that may generate principles associated with Hox patterning of the main body axis in bilaterian metazoa in general and in the vertebrates in particular. We wonder whether this exercise serves any purpose. The features we discuss were already known to us as parts of developmental mechanisms and defining developmental principles (how, and at which level?) adds no insight. We also see little profit in the proposal by Goodwin that there are principles outside the emerging genetic mechanisms that need to be taken into account. The emerging developmental genetic hierarchies already reveal a wealth of interesting phenomena, whatever we choose to call them

Criminal and constable: The impact of policing reform on crime in nineteenth century London.

Educated Londoners in the early 1800s, frightened by crime, tended to demonize the city's criminals, attributing sophistication, organisation and vigour to them. In reality, conventional Metropolitan crime was the product of acute social disorganisation, most of its exponents coming from a marginalised stratum of the urban lower working class. Change in Metropolitan policing was heavily oriented towards combating the unsophisticated, opportunistic, street crime and public disorder that characterised this group's deviance, and (independently of this) at promoting new standards of public order and decorum. The new police made an important, if sometimes exaggerated, contribution to the major reduction in Metropolitan street crime, pickpocketing, robbery, theft from shop fronts, assaults etc. that occurred in the second half of the nineteenth century. They also contributed significantly to the reduction in most other forms of deviance, as well as dramatically enhancing public order. However, historically, the significance of a simple police presence on the streets has been greatly exaggerated. The Metropolitan force were most effective against crime indirectly, promoting social discipline in a manner that closely accords with modern 'broken windows' theory. They were much less successful in directly combating conventional crime. As this became increasingly apparent in the decades after 1829, many came to believe that the institutional result achieved in 1829, and characterised by the triumph of the 'Peelite' school of preventative policing, was inherently flawed. This prompted further change, in particular, a major reassessment of the importance of detective work. Additionally, although a 'broken windows' approach to policing was fairly effective, it had an inescapable darker side. The imposition of new standards of public behaviour and order impinged on many 'traditional' and popular aspects of urban working class life, exciting bitter antipathy amongst the policed. It threatened long accepted civil liberties, which were increasingly attenuated during the century, and impinged on rights to 'due process', which, for minor offences, were greatly reduced. Even more alarmingly, the 'broken windows' approach to urban policing was the raw material for police abuse of power, whether in the form of corruption, perjury or brutality. This was, in part, the price paid for the radically improved personal and public security of the late Victorian period

Two Tier Hox Collinearity Mediates Vertebrate Axial Patterning

A two tier mechanism mediates Hox collinearity. Besides the familiar collinear chromatin modification within each Hox cluster (nanocollinearity), there is also a macrocollinearity tier. Individual Hox clusters and individual cells are coordinated and synchronized to generate multiscale (macro and nano) collinearity in the early vertebrate embryo. Macro-collinearity is mediated by three non-cell autonomous Hox–Hox interactions. These mediate temporal collinearity in early NOM (non-organizer mesoderm), time space translation where temporal collinearity is translated to spatial collinearity along the early embryo’s main body axis and neural transformation, where Hox expression is copied monospecifically from NOM mesoderm to overlying neurectoderm in the late gastrula. Unlike nanocollinearity, which is Hox cluster restricted, axial macrocollinearity extends into the head and EAD domains, thus covering the whole embryonic anterior-posterior (A-P) axis. EAD: extreme anterior domain, the only A-P axial domain anterior to the head. The whole time space translation mechanism interacts with A-P signaling pathways via “decision points,” separating different domains on the axis

Competing Patterns of Signaling Activity in Dictyostelium discoideum

Quantitative experiments are described on spatio-temporal patterns of coherent chemical signaling activity in populations of {\it Dictyostelium discoideum} amoebae. We observe competition between spontaneously firing centers and rotating spiral waves that depends strongly on the overall cell density. At low densities, no complete spirals appear and chemotactic aggregation is driven by periodic concentric waves, whereas at high densities the firing centers seen at early times nucleate and are apparently entrained by spiral waves whose cores ultimately serve as aggregation centers. Possible mechanisms for these observations are discussed.Comment: 10 pages, RevTeX, 4 ps figures, accepted in PR

Experimental aerodynamic characteristics of two V/STOL fighter/attack aircraft configurations at Mach numbers from 1.6 to 2.0

Tests were conducted in the Ames 9 by 7 ft supersonic wind tunnel to measure the aerodynamic characteristics of two horizontal attitude takeoff and landing V/STOL fighter/attack aircraft concepts. One concept featured a jet diffuser ejector for its vertical lift system and the other employed a remote augmentation lift system (RALS). Test results for Mach numbers from 1.6 to 2.0 are reported. Effects of varying the angle of attack (-4 deg to +17 deg), angle of sideslip (-4 deg to +8 deg) Mach number, and configuration building were investigated. The effects of wing trailing edge flap deflections, canard incidence, and vertical tail deflections were also explored as well as the effects of varying the canard longitudinal location and shapes of the inboard nacelle body strakes

Design of Rail Instrumentation for Wind Tunnel Sonic Boom Measurements and Computational-Experimental Comparisons

An innovative pressure rail concept for wind tunnel sonic boom testing of modern aircraft configurations with very low overpressures was designed with an adjoint-based solution-adapted Cartesian grid method. The computational method requires accurate free-air calculations of a test article as well as solutions modeling the influence of rail and tunnel walls. Specialized grids for accurate Euler and Navier-Stokes sonic boom computations were used on several test articles including complete aircraft models with flow-through nacelles. The computed pressure signatures are compared with recent results from the NASA 9- x 7-foot Supersonic Wind Tunnel using the advanced rail design

NASA Ames Sonic Boom Testing

Multiple sonic boom wind tunnel models were tested in the NASA Ames Research Center 9-by 7-Foot Supersonic Wind Tunnel to reestablish related test techniques in this facility. The goal of the testing was to acquire higher fidelity sonic boom signatures with instrumentation that is significantly more sensitive than that used during previous wind tunnel entries and to compare old and new data from established models. Another objective was to perform tunnel-to-tunnel comparisons of data from a Gulfstream sonic boom model tested at the NASA Langley Research Center 4-foot by 4-foot Unitary Plan Wind Tunnel

Bird wings act as a suspension system that rejects gusts

Musculoskeletal systems cope with many environmental perturbations without neurological control. These passive preflex responses aid animals to move swiftly through complex terrain. Whether preflexes play a substantial role in animal flight is uncertain. We investigated how birds cope with gusty environments and found that their wings can act as a suspension system, reducing the effects of vertical gusts by elevating rapidly about the shoulder. This preflex mechanism rejected the gust impulse through inertial effects, diminishing the predicted impulse to the torso and head by 32% over the first 80 ms, before aerodynamic mechanisms took effect. For each wing, the centre of aerodynamic loading aligns with the centre of percussion, consistent with enhancing passive inertial gust rejection. The reduced motion of the torso in demanding conditions simplifies crucial tasks, such as landing, prey capture and visual tracking. Implementing a similar preflex mechanism in future small-scale aircraft will help to mitigate the effects of gusts and turbulence without added computational burden

Extensive polycistronism and antisense transcription in the Mammalian Hox clusters

Animal science