Synthesis, structural characterization and antibacterial studies of some biosensitive mixed ligand copper(II) complexes

1611-1614A series of copper(II) complexes of mixed ligands with Schiff bases derived from 2-aminophenol/2-aminobenzoic acid with substituted benzaldehydes and 1,10-phenonthroline have been synthesized. Microanalytical, magnetic susceptibility, IR, UV-vis, CV, ESR and mass spectral techniques have been used to confirm the structure of these complexes. Their low electrical conductance values indicate that all the complexes are non-electrolytes. The monomeric nature of the complexes is evidenced from their magnetic susceptibility values. Electronic and EPR spectra of the complexes suggest that they have distorted octahedral geometry. The electrochemical behavior, the anodic and cathodic potential and the number of electron transfer have been calculated using cyclic voltammogram. The synthesized compounds have been tested against microorganisms such as Escherichia coli, Bacillus subtilis, Micrococcus luteus and Proteus vulgaris. A comparative study of the MIC values of the ligands and the complexes indicate that the complexes exhibit higher antibacterial activity than the free ligand and control

JSCS–3787 +548.7:615.281–188 Original scientific paper

Designing, synthesis and spectral characterization of Schiff base transition metal complexes: DNA cleavage and antimicrobial activity studie

Synthesis, spectral characterization, theoretical, antimicrobial, DNA interaction and in vitro anticancer studies of Cu(II) and Zn(II) complexes with pyrimidine-morpholine based Schiff base ligand

Novel Cu(II) (1) and Zn(II) (2) complexes with 4-(1-(4-morpholinophenyl)ethylideneamino)pyrimidine-5-carbonitrile) (L) have been synthesized and characterized by various spectroscopic and analytical techniques. DFT (density functional theory) studies result confirms that, LMCT mechanism have been done between L and M(II) ions. The antimicrobial studies indicate that the ligand L and complexes 1 & 2 exhibit higher activity against the E. coli bacteria and C. albicans fungi. The groove binding mode of ligand L and complexes 1 & 2 with CT-DNA have been confirmed by electronic absorption, competitive binding, viscometric and cyclic voltammetric studies. The electronic absorption titration of ligand L and complexes 1 & 2 with DNA have been carried out in different buffer solutions (pH 4.0, 7.0 & 10.0). The Kb values of ligand L and complexes 1 & 2 are higher in acidic buffer at pH 4.0 (Kb = 2.42 × 105, L; 2.8 × 105, 1; 2.65 × 105, 2) and the results revealed that, the interaction of synthesized compounds with DNA were higher in the acidic medium than basic and neutral medium. Furthermore, CT-DNA cleavage studies of ligand L and complexes 1 & 2 have been studied. The in vitro anticancer activities results show that complexes 1 & 2 have moderate cytotoxicity against cancer cell lines and low toxicity on normal cell line than ligand L. Keywords: Pyrimidine, Morpholine, DFT, Antimicrobial, DNA binding, Anticancer studie