458 research outputs found
Scaling of stiffness energy for 3d +/-J Ising spin glasses
Large numbers of ground states of 3d EA Ising spin glasses are calculated for
sizes up to 10^3 using a combination of a genetic algorithm and Cluster-Exact
Approximation. A detailed analysis shows that true ground states are obtained.
The ground state stiffness (or domain wall) energy D is calculated. A D ~ L^t
behavior with t=0.19(2) is found which strongly indicates that the 3d model has
an equilibrium spin-glass-paramagnet transition for non-zero T_c.Comment: 4 pages, 4 figure
Patterns and predictors of inpatient falls and fall-related injuries in a large academic hospital
Specific-Heat Exponent of Random-Field Systems via Ground-State Calculations
Exact ground states of three-dimensional random field Ising magnets (RFIM)
with Gaussian distribution of the disorder are calculated using
graph-theoretical algorithms. Systems for different strengths h of the random
fields and sizes up to N=96^3 are considered. By numerically differentiating
the bond-energy with respect to h a specific-heat like quantity is obtained,
which does not appear to diverge at the critical point but rather exhibits a
cusp. We also consider the effect of a small uniform magnetic field, which
allows us to calculate the T=0 susceptibility. From a finite-size scaling
analysis, we obtain the critical exponents \nu=1.32(7), \alpha=-0.63(7),
\eta=0.50(3) and find that the critical strength of the random field is
h_c=2.28(1). We discuss the significance of the result that \alpha appears to
be strongly negative.Comment: 9 pages, 9 figures, 1 table, revtex revised version, slightly
extende
Ordered phase in the two-dimensional randomly coupled ferromagnet
True ground states are evaluated for a 2d Ising model with random near
neighbor interactions and ferromagnetic second neighbor interactions (the
Randomly Coupled Ferromagnet). The spin glass stiffness exponent is positive
when the absolute value of the random interaction is weaker than the
ferromagnetic interaction. This result demonstrates that in this parameter
domain the spin glass like ordering temperature is non-zero for these systems,
in strong contrast to the 2d Edwards-Anderson spin glass.Comment: 7 pages; 9 figures; revtex; new version much extende
Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.
BACKGROUND—Combination antiplatelet therapy with clopidogrel and aspirin may reduce the rate of recurrent stroke during the first 3 months after a minor ischemic stroke or transient ischemic attack (TIA). A trial of combination antiplatelet therapy in a Chinese population has shown a reduction in the risk of recurrent stroke. We tested this combination in an international population. METHODS—In a randomized trial, we assigned patients with minor ischemic stroke or high-risk TIA to receive either clopidogrel at a loading dose of 600 mg on day 1, followed by 75 mg per day, plus aspirin (at a dose of 50 to 325 mg per day) or the same range of doses of aspirin alone. The dose of aspirin in each group was selected by the site investigator. The primary efficacy outcome in a time-to-event analysis was the risk of a composite of major ischemic events, which was defined as ischemic stroke, myocardial infarction, or death from an ischemic vascular event, at 90 days. RESULTS—A total of 4881 patients were enrolled at 269 international sites. The trial was halted after 84% of the anticipated number of patients had been enrolled because the data and safety monitoring board had determined that the combination of clopidogrel and aspirin was associated with both a lower risk of major ischemic events and a higher risk of major hemorrhage than aspirin alone at 90 days. Major ischemic events occurred in 121 of 2432 patients (5.0%) receiving clopidogrel plus aspirin and in 160 of 2449 patients (6.5%) receiving aspirin plus placebo (hazard ratio, 0.75; 95% confidence interval [CI], 0.59 to 0.95; P = 0.02), with most events occurring during the first week after the initial event. Major hemorrhage occurred in 23 patients (0.9%) receiving clopidogrel plus aspirin and in 10 patients (0.4%) receiving aspirin plus placebo (hazard ratio, 2.32; 95% CI, 1.10 to 4.87; P = 0.02). CONCLUSIONS—In patients with minor ischemic stroke or high-risk TIA, those who received a combination of clopidogrel and aspirin had a lower risk of major ischemic events but a higher risk of major hemorrhage at 90 days than those who received aspirin alone. (Funded by the National Institute of Neurological Disorders and Stroke; POINT ClinicalTrials.gov number, NCT00991029.
A new method for analyzing ground-state landscapes: ballistic search
A ``ballistic-search'' algorithm is presented which allows the identification
of clusters (or funnels) of ground states in Ising spin glasses even for
moderate system sizes. The clusters are defined to be sets of states, which are
connected in state-space by chains of zero-energy flips of spins. The technique
can also be used to estimate the sizes of such clusters. The performance of the
method is tested with respect to different system sizes and choices of
parameters. As an application the ground-state funnel structure of
two-dimensional +or- J spin glasses of systems up to size L=20 is analyzed by
calculating a huge number of ground states per realization. A T=0 entropy per
spin of s_0=0.086(4)k_B is obtained.Comment: 10 pages, 11 figures, 35 references, revte
Fragmentation of protonated ions of peptides containing cysteine, cysteine sulfinic acid, and cysteine sulfonic acid
Ground-state behavior of the 3d +/-J random-bond Ising model
Large numbers of ground states of the three-dimensional random-bond
Ising model are calculated for sizes up to using a combination of a
genetic algorithm and Cluster-Exact Approximation. Several quantities are
calculated as function of the concentration of the antiferromagnetic bonds.
The critical concentration where the ferromagnetic order disappears is
determined using the Binder cumulant of the magnetization. A value of
is obtained. From the finite-size behavior of the Binder
cumulant and the magnetization critical exponents and
are calculated.Comment: 8 pages, 11 figures, revte
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