Supplementary table 3

Filtered differentially expressed mRNA targets of differentially expressed miRNAs (3 weeks time point

Supplementary table 2

Filtered differentially expressed 38 predicted targets of differentially expressed miRNA at 3 and 7 weeks

Identification and analyses of 51 genes differentially expressed at both PND1 and PND70.

<p>A. Intersection of genes differentially expressed at PND1 and PND70. B. Hierarchical clustering of 51 genes differentially expressed at both PND 1 and PND70. C. Principal component analysis of 51 genes differentially expressed at both PND 1 and PND70. (Arrows added for clarity) D. Pathway Architect analysis of 51 genes differentially expressed at both PND 1 and PND70.</p

Plasma ALT and AST in arsenic-exposed and -unexposed PND70 ApoE-knockout mice.

<p>Mean±S.E. n = 8−9 (*p<0.026; #p = 0.056).</p

Determination of As levels in livers of pregnant dams and GD18 fetuses after 10 days exposure to 49 ppm As (as NaAsO2) in drinking water.

<p>Means±SD. P<0.01.</p

Cluster maps of enriched transcription factor binding sites (TFBS) in promoters of genes that are differentially expressed at PND1 (101 genes) and PND70 (135 genes) and also are targets of differentially expressed microRNAs at PND1 (Table S6) and PND70 (Table S11) respectively.

<p>Cluster maps of enriched transcription factor binding sites (TFBS) in promoters of genes that are differentially expressed at PND1 (101 genes) and PND70 (135 genes) and also are targets of differentially expressed microRNAs at PND1 (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038713#pone.0038713.s008" target="_blank">Table S6</a>) and PND70 (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038713#pone.0038713.s013" target="_blank">Table S11</a>) respectively.</p

Diagram of experimental design and analytical flow for mRNA and miRNA data.

<p>Diagram of experimental design and analytical flow for mRNA and miRNA data.</p

Interactome maps of differentially expressed mRNAs in livers of arsenic-exposed mice.

<p>A. PND1; B. PND70. Major hubs are annotated.</p

Network analysis of 51 gene signature.

<p>NC = not changed.</p

microRNAs differentially expressed at PND1 and PND70.

<p>microRNAs differentially expressed at PND1 and PND70.</p