Coordination of growth rate, cell cycle, stress response, and metabolic activity in

We studied the relationship between growth rate and genome-wide gene expression, cell cycle progression, and glucose metabolism in 36 steady-state continuous cultures limited by one of six different nutrients (glucose, ammonium, sulfate, phosphate, uracil, or leucine). The expression of more than one quarter of all yeast genes is linearly correlated with growth rate, independent of the limiting nutrient. The subset of negatively growth-correlated genes is most enriched for peroxisomal functions, whereas positively correlated genes mainly encode ribosomal functions. Many (not all) genes associated with stress response are strongly correlated with growth rate, as are genes that are periodically expressed under conditions of metabolic cycling. We confirmed a linear relationship between growth rate and the fraction of the cell population in the G0/G1 cell cycle phase, independent of limiting nutrient. Cultures limited by auxotrophic requirements wasted excess glucose, whereas those limited on phosphate, sulfate, or ammonia did not; this phenomenon (reminiscent of the “Warburg effect ” in cancer cells) was confirmed in batch cultures. Using an aggregate of gene expression values, we predict (in both continuous and batch cultures) an “instantaneous growth rate. ” This concept is useful in interpreting the system-level connections among growth rate, metabolism, stress, and the cell cycle

Relativistic theory of inverse beta-decay of polarized neutron in strong magnetic field

The relativistic theory of the inverse beta-decay of polarized neutron, $\nu _{e} + n \to p + e ^{-}$, in strong magnetic field is developed. For the proton wave function we use the exact solution of the Dirac equation in the magnetic filed that enables us to account exactly for effects of the proton momentum quantization in the magnetic field and also for the proton recoil motion. The effect of nucleons anomalous magnetic moments in strong magnetic fields is also discussed. We examine the cross section for different energies and directions of propagation of the initial neutrino accounting for neutrons polarization. It is shown that in the super-strong magnetic field the totally polarized neutron matter is transparent for neutrinos propagating antiparallel to the direction of polarization. The developed relativistic approach can be used for calculations of cross sections of the other URCA processes in strong magnetic fields.Comment: 41 pages in LaTex including 11 figures in PostScript, discussion on nucleons AMM interaction with magnetic field is adde

Neutrino opacity in magnetised hot and dense nuclear matter

We study the neutrino interaction rates in hot matter at high densities in the presence of uniform magnetic field. The neutrino cross-sections involving both the charged current absorption and neutral current scattering reactions on baryons and leptons have been considered. We have in particular considered the interesting case when the magnetic field is strong enough to completely polarise the protons and electrons in supernovae and neutron stars. The opacity in such a situation is considerably modified and the cross-section develops anisotropy. This has implications for phenomenon invoked in the literature to explain the observed pulsar kicks.Comment: 22 latex pages and 7 postscript figure

Neutrino propagation in a random magnetic field

The active-sterile neutrino conversion probability is calculated for neutrino propagating in a medium in the presence of random magnetic field fluctuations. Necessary condition for the probability to be positive definite is obtained. Using this necessary condition we put constraint on the neutrino magnetic moment from active-sterile electron neutrino conversion in the early universe hot plasma and in supernova.Comment: 11 page

Multiwavelength optical observations of chromospherically active binary systems V. FF UMa (2RE J0933+624): a system with orbital period variation

This is the fifth paper in a series aimed at studying the chromospheres of active binary systems using several optical spectroscopic indicators to obtain or improve orbital solution and fundamental stellar parameters. We present here the study of FF UMa (2RE J0933+624), a recently discovered, X-ray/EUV selected, active binary with strong H_alpha emission. The objectives of this work are, to find orbital solutions and define stellar parameters from precise radial velocities and carry out an extensive study of the optical indicators of chromospheric activity. We obtained high resolution echelle spectroscopic observations during five observing runs from 1998 to 2004. We found radial velocities by cross correlation with radial velocity standard stars to achieve the best orbital solution. We also measured rotational velocity by cross-correlation techniques and have studied the kinematic by galactic space- velocity components (U, V, W) and Eggen criteria. Finally, we have determined the chromospheric contribution in optical spectroscopic indicators, from Ca II H & K to Ca II IRT lines, using the spectral subtraction technique. We have found that this system presents an orbital period variation, higher than previously detected in other RS CVn systems. We determined an improved orbital solution, finding a circular orbit with a period of 3.274 days. We derived the stellar parameters, confirming the subgiant nature of the primary component and obtained rotational velocities (vsini), of 33.57 km/s and 32.38 km/s for the primary and secondary components respectively. From our kinematic study, we can deduce its membership to the Castor moving group. Finally, the activity study has given us a better understanding of the possible mechanisms that produce the orbital period variation.Comment: Latex file with 16 pages, 18 figures. Available at http://www.ucm.es/info/Astrof/invest/actividad/actividad_pub.html Accepted for publication in: Astronomy & Astrophysics (A&A

Habitable Zones in the Universe

Habitability varies dramatically with location and time in the universe. This was recognized centuries ago, but it was only in the last few decades that astronomers began to systematize the study of habitability. The introduction of the concept of the habitable zone was key to progress in this area. The habitable zone concept was first applied to the space around a star, now called the Circumstellar Habitable Zone. Recently, other, vastly broader, habitable zones have been proposed. We review the historical development of the concept of habitable zones and the present state of the research. We also suggest ways to make progress on each of the habitable zones and to unify them into a single concept encompassing the entire universe.Comment: 71 pages, 3 figures, 1 table; to be published in Origins of Life and Evolution of Biospheres; table slightly revise

The characteristics of millisecond pulsar emission: I. Spectra, pulse shapes and the beaming fraction

We have monitored a large sample of millisecond pulsars using the 100-m Effelsberg radio telescope in order to compare their radio emission properties to the slowly rotating population. With some notable exceptions, our findings suggest that the two groups of objects share many common properties. A comparison of the spectral indices between samples of normal and millisecond pulsars demonstrates that millisecond pulsar spectra are not significantly different from those of normal pulsars. There is evidence, however, that millisecond pulsars are slightly less luminous and less efficient radio emitters compared to normal pulsars. We confirm recent suggestions that a diversity exists among the luminosities of millisecond pulsars with the isolated millisecond pulsars being less luminous than the binary millisecond pulsars. There are indications that old millisecond pulsars exhibit somewhat flatter spectra than the presumably younger ones. We present evidence that millisecond pulsar profiles are only marginally more complex than those found among the normal pulsar population. Moreover, the development of the profiles with frequency is rather slow, suggesting very compact magnetospheres. The profile development seems to anti-correlate with the companion mass and the spin period, again suggesting that the amount of mass transfer in a binary system might directly influence the emission properties. The angular radius of radio beams of millisecond pulsars does not follow the scaling predicted from a canonical pulsar model which is applicable for normal pulsars. Instead they are systematically smaller. The smaller inferred luminosity and narrower emission beams will need to be considered in future calculations of the birth-rate of the Galactic population.Comment: 40 pages, 14 figures, accepted for publication in Ap

Neutrino-Nucleon Interactions in Magnetized Neutron-Star Matter: The Effects of Parity Violation

We study neutrino-nucleon scattering and absorption in a dense, magnetized nuclear medium. These are the most important sources of neutrino opacity governing the cooling of a proto-neutron star in the first tens of seconds after its formation. Because the weak interaction is parity violating, the absorption and scattering cross-sections depend asymmetrically on the directions of the neutrino momenta with respect to the magnetic field. We develop the moment formalism of neutrino transport in the presence of such asymmetric opacities and derive explicit expressions for the neutrino flux and other angular moments of the Boltzmann transport equation. For a given neutrino species, there is a drift flux of neutrinos along the magnetic field in addition to the usual diffusive flux. This drift flux depends on the deviation of the neutrino distribution function from thermal equilibrium. Hence, despite the fact that the neutrino cross-sections are asymmetric throughout the star, asymmetric neutrino flux can be generated only in the outer region of the proto-neutron star where the neutrino distribution deviates significantly from thermal equilibrium. In addition to the asymmetric absorption opacity arising from nucleon polarization, we find the contribution of the electron (or positron) ground state Landau level. For neutrinos of energy less than a few times the temperature, this is the dominant source of asymmetric opacity. Lastly, we discuss the implication of our result to the origin of pulsar kicks: in order to generate kick velocity of a few hundred km/s from asymmetric neutrino emission using the parity violation effect, the proto-neutron star must have a dipole magnetic field of at least $10^{15}-10^{16}$ G.Comment: 35 pages, no figures, submitted to Phys.Rev.

Astrobiological Complexity with Probabilistic Cellular Automata

Search for extraterrestrial life and intelligence constitutes one of the major endeavors in science, but has yet been quantitatively modeled only rarely and in a cursory and superficial fashion. We argue that probabilistic cellular automata (PCA) represent the best quantitative framework for modeling astrobiological history of the Milky Way and its Galactic Habitable Zone. The relevant astrobiological parameters are to be modeled as the elements of the input probability matrix for the PCA kernel. With the underlying simplicity of the cellular automata constructs, this approach enables a quick analysis of large and ambiguous input parameters' space. We perform a simple clustering analysis of typical astrobiological histories and discuss the relevant boundary conditions of practical importance for planning and guiding actual empirical astrobiological and SETI projects. In addition to showing how the present framework is adaptable to more complex situations and updated observational databases from current and near-future space missions, we demonstrate how numerical results could offer a cautious rationale for continuation of practical SETI searches.Comment: 37 pages, 11 figures, 2 tables; added journal reference belo