14,171 research outputs found
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How Useful are High-Precision Delta ?17O Data in Defining the Asteroidal Sources of Meteorites?: Evidence from Main-Group Pallasites, Primitive and Differentiated Achondrites
High-precision oxygen isotope analysis is capable of revealing important information about the relationship between different meteorite groups. New data confirm that the main-group pallasites are from a distinct source to either the HEDs or mesosiderites
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The rocks from space initiative and the space safari
This paper reports the successes of a new initiative in the UK using electronic resources, such as virtual learning environments and e-classrooms, for planetary and space science public engagement activities
Dry Friction due to Adsorbed Molecules
Using an adiabatic approximation method, which searches for Tomlinson
model-like instabilities for a simple but still realistic model for two
crystalline surfaces in the extremely light contact limit, with mobile
molecules present at the interface, sliding relative to each other, we are able
to account for the virtually universal occurrence of "dry friction." The model
makes important predictions for the dependence of friction on the strength of
the interaction of each surface with the mobile molecules.Comment: four pages of latex, figure provide
Study of high altitude plume impingement
Computer program has been developed as analytical tool to predict severity of effects of exhaust of rocket engines on adjacent spacecraft surfaces. Program computes forces, moments, pressures, and heating rates on surfaces immersed in or subjected to exhaust plume environments. Predictions will be useful in design of systems where such problems are anticipated
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Oxygen isotope ratios of large cosmic spherules: Carbonaceous and ordinary chondrite parent bodies
Development and critical evaluation of a generic 2-D agro-hydrological model (SMCR_N) for the responses of crop yield and nitrogen composition to nitrogen fertilizer
Models play an important role in optimizing fertilizer use in agriculture to maintain sustainable crop production and to minimize the risk to the environment. In this study, we present a new Simulation Model for Crop Response to Nitrogen fertilizer (SMCR_N). The SMCR_N model, based on the recently developed model EU-Rotate_N for the N-economies of a wide range of crops and cropping systems, includes new modules for the estimation of N in the roots and an associated treatment of the recovery of soil mineral N by crops, for the reduction of growth rates by excessive fertilizer-N, and for the N mineralization from soil organic matter. The validity of the model was tested against the results from 32 multi-level fertilizer experiments on 16 different crop species. For this exercise none of the coefficients or parameters in the model was adjusted to improve the agreement between measurement and simulation. Over the practical range of fertilizer-N levels model predictions were, with few exceptions, in good agreement with measurements of crop dry weight (excluding fibrous roots) and its %N. The model considered that the entire reduction of soil inorganic N during growth was due to the sum of nitrate leaching, retention of N in fibrous roots and N uptake by the rest of the plant. The good agreement between the measured and simulated uptakes suggests that in this arable soil, losses of N from other soil processes were small. At high levels of fertilizer-N yields were dominated by the negative osmotic effect of fertilizer-N and model predictions for some crops were poor. However, the predictions were significantly improved by using a different value for the coefficient defining the osmotic effect for saline sensitive crops. The developed model SMCR_N uses generally readily available inputs, and is more mechanistic than most agronomic models and thus has the potential to be used as a tool for optimizing fertilizer practice
Generation of internal stress and its effects
Internal stresses may be generated continually in many polycrystalline materials. Their existence is manifested by changes in crystal defect concentration and arrangement, by surface observations, by macroscopic shape changes and particularly by alteration of mechanical properties when external stresses are simultaneously imposed
The measurement of the winds near the ocean surface with a radiometer-scatterometer on Skylab
The author has identified the following significant results. There were a total of twenty-six passes in the ZLV mode that yielded useful data. Six were in the in-track noncontiguous mode; all others were in the cross-track noncontiguous mode. The wind speed and direction, as effectively determined in a neutral atmosphere at 19.5 m above the sea surface, were found for each cell scanned by S193. It is shown how the passive microwave measurements were used both to compute the attenuation of the radar beam and to determine those cells where the backscatter measurement was suspect. Given the direction of the wind from some independent source, with the typical accuracy of measurement by available meteorological methods, a backscatter measurement at a nadir angle of 50, 43, or 32 deg can be used to compute the speed of the wind averaged over the illuminated area
Functional Evaluation of AMD-Associated Risk Variants of Complement Factor B
Purpose: The 32W and 32Q variants of complement factor B (CFB) are associated with reduced risk of developing neovascular age-related macular degeneration (AMD) compared with the common 32R allele. The objective of this study was to determine if the most protective R32Q variant affects the neovascular process in a manner consistent with the reported reduced disease association.
Methods: The 32R, 32W, and 32Q human CFB variants were expressed in human embryonic kidney 293T cells and purified from culture supernatant. The ex vivo mouse fetal metatarsal explant model was used to investigate the effect of these three human CFB variants on angiogenesis. Metatarsal bones were isolated from mouse embryos and cultured in the presence of the three CFB variants, and angiogenesis was measured following immunostaining of fixed samples. ELISAs were used to quantify C3 and VEGF protein levels in metatarsal culture and quantitative PCR to measure Cfb, C3, and Vegf expression.
Results: We show here that the three CFB variants have different biological activities in the mouse metatarsal assay, with CFBR32 exhibiting significantly greater angiogenic activity than CFBQ32 or CFBW32, which were broadly similar. We also observed differences in macrophage phenotype with these two variants that may contribute to their activities in this experimental model.
Conclusions: We have demonstrated that the biological activities of CFBR32, CFBW32, and CFBQ32 are consistent with their AMD risk association, and we provide functional evidence of roles for these variants in angiogenesis that may be relevant to the pathogenesis of the neovascular form of AMD
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