Comparison Analysis Between Male and Female of Consumer Purchase Behavior of Yamaha Mio

Humans have many needs and wants that they must fulfill in his life. Motorcycles is one requirement that must be met to be used as a means of transportation. Male and female have their own criteria for selecting the type of motorcycle they want. Male and female have different decision-making to buy a motorcycle. The method used in this research is the method of comparative data, collecting data through questionnaires, data analysis methods (validity and reliability), hypothesis testing and independent sample t-test. The results showed a significant difference between male and female in the purchasing behavior of consumers towards Yamaha Mio. Yamaha Mio sellers should consider offering their products for men and women differently. Keywords: decision making, consumer purchase behavio

Direct compression properties of microcrystalline cellulose and its silicified product

The influence of silicified microcrystalline cellulose (SMCC) on the flow, compaction and tableting properties of metronidazole powder was investigated. The study compared medium grades of both SMCC and standard microcrystalline cellulose (MCC) as direct compressible excipients. The bulk densities, Hausner quotient (Hf), compressibility index (CI) and angle of repose of the formulations were evaluated. Compacts of the metronidazole containing different concentrations of SMCC or MCC (10-30% w/w) were made at compression forces of 20 to 30 KN and evaluated for their physical characteristics. The flow behaviour of the drug was improved in the presence of SMCC. Formulations containing 25% w/w SMCC had lower CI and Hf values than those made with 30% w/w MCC. The crushing strength of the compacts increased with concentration of the excipients at all the compression forces used. At similar concentrations of SMCC and MCC, compacts of the formulations containing SMCC exhibited higher crushing strengths. SMCC shows great promise as a filler-binder-disintegrant in direct compression of oral tablet formulations from both mechanical and economic viewpoints. Keywords: metronidazole, tablets, direct compression, Silicified Microcrystalline cellulose, microcrystalline celluloseThe East and Central African Journal of Pharmaceutical Sciences Vol. 7(3) 2004: 56-5

Chemical properties of thymoquinone, a monoterpene isolated from the seeds of Nigella sativa Linn.

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Thymoquinone is the main ingredient of the essential oil extracted from the seeds of Nigella sativa L. (Ranunculaceae). The monoterpene is considered to be the active pharmaceutical ingredient in the seeds, which have traditionally been highly prized for their medicinal properties. The compound has been the focus of a considerable number of pharmacological investigations and has been reviewed regularly for its action against a variety of inflammatory diseases, its effect on metabolic syndrome, and its potential anticancer properties. While discussing the chemical and pharmacological properties of thymoquinone, recent reviews have reflected on the keto-enol tautomerism of thymoquinone. Specifically, thymoquinone is described as a tautomeric compound, where the keto-form is said to be the major configuration that is responsible for its pharmacological properties [1, 2]. In both reviews, reference is made to a 2005 review by Salem [3]. The latter review discusses a range of activities of thymoquinone, mainly on cell signalling and antioxidant (scavenging) molecular mediators involved in the process of inflammation. However, no mention is made in this review of keto- or enol forms of thymoquinone. Moreover, the chemical structure of thymoquinone does not allow keto-enol tautomerism

Pengembangan Sistem Manajemen Pembelajaran Pemrograman Bahasa Scheme, Java, PHP, dan Perl

Secara konvensional proses pembelajaran dilakukan dalam bentuk diskusi ataupun penyampaian materi di dalam suatu kelas atau perkuliahan. Proses pembelajaran seperti ini sulit diterapkan pada bidang pemrograman terutama untuk kelas besar. Keterampilan dalam membuat suatu algoritme, logika, bahasa pemrograman, dan pengetahuan-pengetahuan lain seperti matematika juga sangat diperlukan dalam membuat suatu program komputer. Pada kondisi ini, sistem manajemen pembelajaran atau learning management system (LMS) memiliki peranan penting dalam melengkapi dan memperbaiki proses pembelajaran konvensional di bidang pemrograman. Tim Olimpiade Komputer Indonesia (TOKI) telah mengembangkan aplikasi SMP pemrograman yang disebut TOKI Learning Contest (LC) untuk bahasa pemrograman Pascal, C, dan C++. Penelitian ini menganalisis TOKI LC dan mengembangkan sistem manajemen pembelajaran agar dapat mendukung dan melengkapi proses pembelajaran di bidang pemrograman untuk mahasiswa bidang studi ilmu komputer atau informatika dengan menambahkan sistem penilaian bahasa Scheme, Java, PHP, dan Perl dan menguji kinerja masing-masing bahasa. Penelitian ini telah menambahkan grader otomatis untuk empat bahasa pemrograman yaitu Scheme, Java, PHP, dan Perl, yang memenuhi konsep asynchronous e-learning. Hasil menunjukkan bahwa kinerja run time pada bahasa pemrograman Java menggunakan waktu yang lebih lama. Selain itu penggunaan memory space pada bahasa Java menggunakan memori yang cukup besar untuk menjalankan setiap program dibandingkan bahasa pemrograman lain

Produktivitas Penangkapan Ikan Tenggiri (Scomberomorus Commerson) Menggunakan Pancing Ulur Di PerairanKabupaten Bintan

Mackerel is one of the main targets of hand line fishing in the Tambelan coastal waters, Bintan Regency. The mackerel catch data were collected by following the hand line fishing operation as many as 40 trips from December 2013 to April 2014. The productivity data of hand line fishing were calculated based on the time of fishing operations (morning, noon, afternoon). The average productivity of hand line fishing in the morning, daytime and afternoon were 0.051 kg/minutes, 0.036 kg/minutes and 0.033 kg/minutes, respectively. Handline fishing productivity in the morning was not significantly different with at the daytime, however there was a significant different in productivity between in the morning and in the afternoon. Whilst, the fishing productivity at the daytime was not significantly different with that in the afternoon

Promosi, Harga dan Kualitas Layanan terhadap Keputusan Konsumen Menggunakan Listrik Pintar pada Wilayah Manado Malalayang 1

Perkembangan dunia bisnis kini semakin dinamis seiring dengan semakin meningkatnya permintaan masyarakat terhadap produk dan jasa untuk memenuhi segala kebutuhannya. PT. PLN (Persero) adalah Perusahan BUMN yang bergerak dibidang penyediaan jasa kelistrikan di Indonesia, salah satunya adalah PT. PLN (Persero) cabang Manado sebagai agen listrik yang bertugas untuk membangun kegiatan-kegiatan usaha yang berkaitan dengan kelistrikan, yang tujuan untuk meningkatkan kesejahteraan masyarakat serta mendorong peningkatan ekonomi. Penelitian ini bertujuan untuk menguji pengaruh promosi, harga dan kualitas layanan terhadap keputusan konsumen. Metode penelitian yang di gunakan asosiatif. Populasi penelitian ini berjumlah 703 pengguna dan sampel yang digunakan sebanyak 100 orang. Teknik sampling yang digunakan adalah sampling jenuh. Variabel yang digunakan keputusan konsumen, promosi, harga dan kualitas layanan. Teknik analisis yang digunakan adalah regersi linier berganda. Hasil analisis menunjukan promosi, harga dan kualitas layanan berpengaruh secara simultan terhadap keputusan konsumen. Sedangkan analisis parsial menunjukan hanya untuk kualitas layanan yang berpengaruh signifikan terhadap keputusan konsumen. Pihak PLN sebaiknya memperhatikan faktor harga karena berpengaruh terhadap keputusan konsumen. Kata kunci: promosi, harga, kualitas layanan, keputusan konsume

CRISPR Associated Diversity within a Population of Sulfolobus islandicus

Predator-prey models for virus-host interactions predict that viruses will cause oscillations of microbial host densities due to an arms race between resistance and virulence. A new form of microbial resistance, CRISPRs (clustered regularly interspaced short palindromic repeats) are a rapidly evolving, sequence-specific immunity mechanism in which a short piece of invading viral DNA is inserted into the host's chromosome, thereby rendering the host resistant to further infection. Few studies have linked this form of resistance to population dynamics in natural microbial populations.We examined sequence diversity in 39 strains of the archeaon Sulfolobus islandicus from a single, isolated hot spring from Kamchatka, Russia to determine the effects of CRISPR immunity on microbial population dynamics. First, multiple housekeeping genetic markers identify a large clonal group of identical genotypes coexisting with a diverse set of rare genotypes. Second, the sequence-specific CRISPR spacer arrays split the large group of isolates into two very different groups and reveal extensive diversity and no evidence for dominance of a single clone within the population.The evenness of resistance genotypes found within this population of S. islandicus is indicative of a lack of strain dominance, in contrast to the prediction for a resistant strain in a simple predator-prey interaction. Based on evidence for the independent acquisition of resistant sequences, we hypothesize that CRISPR mediated clonal interference between resistant strains promotes and maintains diversity in this natural population

Truncation in the tcdC region of the Clostridium difficile PathLoc of clinical isolates does not predict increased biological activity of Toxin B or Toxin A

<p>Abstract</p> <p>Background</p> <p>The increased severity of disease associated with the NAP1 strain of <it>Clostridium difficile </it>has been attributed to mutations to the <it>tcdC </it>gene which codes for a negative regulator of toxin production. To assess the role of hyper-production of Toxins A and B in clinical isolates of <it>Clostridium difficile</it>, two NAP1-related and five NAP1 non-related strains were compared.</p> <p>Methods</p> <p>Sequencing was performed on <it>tcdC</it>, <it>tcdR</it>, and <it>tcdE</it> to determine if there were differences that might account for hyper-production of Toxin A and Toxin B in NAP1-related strains. Biological activity of Toxin B was evaluated using the HFF cell CPE assay and Toxin A biological activity was assessed using the Caco-2 Trans-membrane resistance assay.</p> <p>Results</p> <p>Our results confirm that Toxin A and Toxin B production in NAP1-related strains and ATCC 43255 occurs earlier in the exponential growth phase compared to most NAP1-nonrelated clinical isolates. Despite the hyper-production observed in ATCC 43255 it had no mutations in <it>tcdC</it>, <it>tcdR </it>or <it>tcdE</it>. Analysis of the other clinical isolates indicated that the kinetics and ultimate final concentration of Toxin A and B did not correlate with the presence or lack of alterations in <it>tcdC</it>, <it>tcdR </it>or <it>tcdE</it>.</p> <p>Conclusion</p> <p>Our data do not support a direct role for alterations in the <it>tcdC </it>gene as a predictor of hyperproduction of Toxin A and B in NAP1-related strains.</p