405 research outputs found
Overview of ASDEX Upgrade results
The ASDEX Upgrade (AUG) programme is directed towards physics input to critical
elements of the ITER design and the preparation of ITER operation, as well as addressing
physics issues for a future DEMO design. Since 2015, AUG is equipped with a new pair of
3-strap ICRF antennas, which were designed for a reduction of tungsten release during ICRF
operation. As predicted, a factor two reduction on the ICRF-induced W plasma content could
be achieved by the reduction of the sheath voltage at the antenna limiters via the compensation
of the image currents of the central and side straps in the antenna frame. There are two main
operational scenario lines in AUG. Experiments with low collisionality, which comprise
current drive, ELM mitigation/suppression and fast ion physics, are mainly done with freshly
boronized walls to reduce the tungsten influx at these high edge temperature conditions. Full
ELM suppression and non-inductive operation up to a plasma current of Ip = 0.8 MA could
be obtained at low plasma density. Plasma exhaust is studied under conditions of high neutral
divertor pressure and separatrix electron density, where a fresh boronization is not required.
Substantial progress could be achieved for the understanding of the confinement degradation
by strong D puffing and the improvement with nitrogen or carbon seeding. Inward/outward
shifts of the electron density profile relative to the temperature profile effect the edge stability
via the pressure profile changes and lead to improved/decreased pedestal performance.
Seeding and D gas puffing are found to effect the core fueling via changes in a region of high
density on the high field side (HFSHD).
The integration of all above mentioned operational scenarios will be feasible and
naturally obtained in a large device where the edge is more opaque for neutrals and higher
plasma temperatures provide a lower collisionality. The combination of exhaust control
with pellet fueling has been successfully demonstrated. High divertor enrichment values of
nitrogen EN 10 have been obtained during pellet injection, which is a prerequisite for the
simultaneous achievement of good core plasma purity and high divertor radiation levels.
Impurity accumulation observed in the all-metal AUG device caused by the strong neoclassical
inward transport of tungsten in the pedestal is expected to be relieved by the higher
neoclassical temperature screening in larger devices.European Commission (EUROfusion 633053
Overview of progress in European medium sized tokamaks towards an integrated plasma-edge/wall solution
Integrating the plasma core performance with an edge and scrape-off layer (SOL) that leads
to tolerable heat and particle loads on the wall is a major challenge. The new European
medium size tokamak task force (EU-MST) coordinates research on ASDEX Upgrade
(AUG), MAST and TCV. This multi-machine approach within EU-MST, covering a wide
parameter range, is instrumental to progress in the field, as ITER and DEMO core/pedestal
and SOL parameters are not achievable simultaneously in present day devices. A two prong
approach is adopted. On the one hand, scenarios with tolerable transient heat and particle
loads, including active edge localised mode (ELM) control are developed. On the other hand,
divertor solutions including advanced magnetic configurations are studied. Considerable
progress has been made on both approaches, in particular in the fields of: ELM control with
resonant magnetic perturbations (RMP), small ELM regimes, detachment onset and control,
as well as filamentary scrape-off-layer transport. For example full ELM suppression has now
been achieved on AUG at low collisionality with n = 2 RMP maintaining good confinement
HH(98,y2) 0.95. Advances have been made with respect to detachment onset and control.
Studies in advanced divertor configurations (Snowflake, Super-X and X-point target divertor)
shed new light on SOL physics. Cross field filamentary transport has been characterised in a
wide parameter regime on AUG, MAST and TCV progressing the theoretical and experimental
understanding crucial for predicting first wall loads in ITER and DEMO. Conditions in the
SOL also play a crucial role for ELM stability and access to small ELM regimes.European Commission (EUROfusion 633053
Functional improvement and correlations with symptomatic improvement in adults with attention deficit hyperactivity disorder receiving long-acting methylphenidate
Item does not contain fulltextBACKGROUND: Data on the relationship between core symptoms and daily functioning in adults with attention deficit hyperactivity disorder (ADHD) are limited. Daily functioning was assessed as part of an open-label extension, and associations with symptom scores were evaluated. METHOD: After a 5-week double-blind study with adults with ADHD receiving osmotic-controlled release oral delivery system (OROS) methylphenidate (MPH) 18, 36 or 72 mg/day, or placebo, participants were eligible for a 7-week open-label extension in which all patients received OROS MPH. Data for the Conners' Adult ADHD Rating Scale - Observer: Screening Version (CAARS-O:SV) (primary endpoint) have been presented previously. Secondary endpoints included the observer self-reported short version of the CAARS (CAARS-S:S) and the Clinical Global Impressions - Severity Scale (CGI-S). Daily functioning and quality of life were assessed using the Sheehan Disability Scale (SDS) and the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) respectively. In post-hoc analyses, changes in CAARS-O:SV were evaluated in subgroups. Relationships between symptom and functional outcomes were evaluated in a multivariate regression analysis. RESULTS: A total of 370 patients entered the open-label extension. Significant improvements from baseline in CAARS-O:SV were similar regardless of sex, ADHD subtype, prior treatment or psychiatric co-morbidity. Significant improvements from double-blind baseline were also seen for the CAARS-S:S, CGI-S, SDS and Q-LES-Q. Improvements in the CAARS-O:SV Hyperactivity/Impulsivity subscale were associated with improvements in SDS total and subscale scores, and in the Q-LES-Q score at open-label endpoint. Improvements in CAARS-O:SV Inattention subscale and CGI-S scores were not significantly associated with functional changes. CONCLUSIONS: Improvements in ADHD symptoms relating to hyperactivity and impulsivity in adults receiving OROS MPH are associated with improvements in daily functioning and quality of life.1 januari 201
The Conners Continuous Performance Test CPT3™: Is it a reliable marker to predict neurocognitive dysfunction in Myalgic encephalomyelitis/chronic fatigue syndrome?
IntroductionThe main objective is to delimit the cognitive dysfunction associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in adult patients by applying the Continuous Performance Test (CPT3™). Additionally, provide empirical evidence on the usefulness of this computerized neuropsychological test to assess ME/CFS.MethodThe final sample (n = 225; 158 Patients/67 Healthy controls) were recruited in a Central Sensitization Syndromes (CSS) specialized unit in a tertiary hospital. All participants were administered this neuropsychological test.ResultsThere were significant differences between ME/CFS and healthy controls in all the main measures of CPT3™. Mainly, patients had a worse indicator of inattentiveness, sustained attention, vigilance, impulsivity, slow reaction time, and more atypical T-scores, which is associated with a likelihood of having a disorder characterized by attention deficits, such as Attention Deficit Hyperactivity Disorder (ADHD). In addition, relevant correlations were obtained between the CPT3™ variables in the patient’s group. The most discriminative indicators of ME/CFS patients were Variability and Hit Reaction Time, both measures of response speed.ConclusionThe CPT3™ is a helpful tool to discriminate neurocognitive impairments from attention and response speed in ME/CFS patients, and it could be used as a marker of ME/CFS severity for diagnosing or monitoring this disease
Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
Attention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric disorders and traits. In this review, we summarize and interpret the existing literature on the genetic architecture of these comorbidities based on hypothesis-generating approaches. Quantitative genetic studies indicate that genetic factors play a substantial role in the observed co-occurrence of ADHD with many different disorders and traits. Molecular genetic correlations derived from genome-wide association studies and results of studies based on polygenic risk scores confirm the general pattern but provide effect estimates that are smaller than those from twin studies. The identification of the specific genetic variants and biological pathways underlying co-occurrence using genome-wide approaches is still in its infancy. The first analyses of causal inference using genetic data support causal relationships between ADHD and comorbid disorders, although bidirectional effects identified in some instances point to complex relationships. While several issues in the methodology and inferences from the results are still to be overcome, this review shows that the co-occurrence of ADHD with many psychiatric disorders and traits is genetically interpretable.</p
Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
Attention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric disorders and traits. In this review, we summarize and interpret the existing literature on the genetic architecture of these comorbidities based on hypothesis-generating approaches. Quantitative genetic studies indicate that genetic factors play a substantial role in the observed co-occurrence of ADHD with many different disorders and traits. Molecular genetic correlations derived from genome-wide association studies and results of studies based on polygenic risk scores confirm the general pattern but provide effect estimates that are smaller than those from twin studies. The identification of the specific genetic variants and biological pathways underlying co-occurrence using genome-wide approaches is still in its infancy. The first analyses of causal inference using genetic data support causal relationships between ADHD and comorbid disorders, although bidirectional effects identified in some instances point to complex relationships. While several issues in the methodology and inferences from the results are still to be overcome, this review shows that the co-occurrence of ADHD with many psychiatric disorders and traits is genetically interpretable.</p
First measurements of a scintillator based fast-ion loss detector near the ASDEX Upgrade divertor
Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
Attention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric disorders and traits. In this review, we summarize and interpret the existing literature on the genetic architecture of these comorbidities based on hypothesis-generating approaches. Quantitative genetic studies indicate that genetic factors play a substantial role in the observed co-occurrence of ADHD with many different disorders and traits. Molecular genetic correlations derived from genome-wide association studies and results of studies based on polygenic risk scores confirm the general pattern but provide effect estimates that are smaller than those from twin studies. The identification of the specific genetic variants and biological pathways underlying co-occurrence using genome-wide approaches is still in its infancy. The first analyses of causal inference using genetic data support causal relationships between ADHD and comorbid disorders, although bidirectional effects identified in some instances point to complex relationships. While several issues in the methodology and inferences from the results are still to be overcome, this review shows that the co-occurrence of ADHD with many psychiatric disorders and traits is genetically interpretable.</p
Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
Attention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric disorders and traits. In this review, we summarize and interpret the existing literature on the genetic architecture of these comorbidities based on hypothesis-generating approaches. Quantitative genetic studies indicate that genetic factors play a substantial role in the observed co-occurrence of ADHD with many different disorders and traits. Molecular genetic correlations derived from genome-wide association studies and results of studies based on polygenic risk scores confirm the general pattern but provide effect estimates that are smaller than those from twin studies. The identification of the specific genetic variants and biological pathways underlying co-occurrence using genome-wide approaches is still in its infancy. The first analyses of causal inference using genetic data support causal relationships between ADHD and comorbid disorders, although bidirectional effects identified in some instances point to complex relationships. While several issues in the methodology and inferences from the results are still to be overcome, this review shows that the co-occurrence of ADHD with many psychiatric disorders and traits is genetically interpretable.</p
Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
Attention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric disorders and traits. In this review, we summarize and interpret the existing literature on the genetic architecture of these comorbidities based on hypothesis-generating approaches. Quantitative genetic studies indicate that genetic factors play a substantial role in the observed co-occurrence of ADHD with many different disorders and traits. Molecular genetic correlations derived from genome-wide association studies and results of studies based on polygenic risk scores confirm the general pattern but provide effect estimates that are smaller than those from twin studies. The identification of the specific genetic variants and biological pathways underlying co-occurrence using genome-wide approaches is still in its infancy. The first analyses of causal inference using genetic data support causal relationships between ADHD and comorbid disorders, although bidirectional effects identified in some instances point to complex relationships. While several issues in the methodology and inferences from the results are still to be overcome, this review shows that the co-occurrence of ADHD with many psychiatric disorders and traits is genetically interpretable.</p
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