Dissipative particle dynamics: the equilibrium for finite time steps

Dissipative particle dynamics (DPD) is a relatively new technique which has proved successful in the simulation of complex fluids. We caution that for the equilibrium achieved by the DPD simulation of a simple fluid the temperature depends strongly on the time step. An analytic expression for the dependence is obtained and shown to agree well with simulation results.Comment: 5 pages, LaTeX, 1 Postscript figure, submitted to Europhys.Letts., Algebraic corrections made to final resul

A Young Planetary-Mass Object in the ρ Oph Cloud Core

We report the discovery of a young planetary-mass brown dwarf in the ρ Oph cloud core. The object was identified as such with the aid of a 1.5-2.4 μm low-resolution spectrum obtained using the NIRC instrument on the Keck I telescope. Based on the COND model, the observed spectrum is consistent with a reddened (A_V ~ 15-16) brown dwarf whose effective temperature is in the range 1200-1800 K. For an assumed age of 1 Myr, comparison with isochrones further constrains the temperature to ~1400 K and suggests a mass of ~2-3 Jupiter masses. The inferred temperature is suggestive of an early T spectral type, which is supported by spectral morphology consistent with weak methane absorption. Based on its inferred distance (~100 pc) and the presence of overlying visual absorption, it is very likely to be a ρ Oph cluster member. In addition, given the estimated spectral type, it may be the youngest and least massive T dwarf found so far. Its existence suggests that the initial mass function for the ρ Oph star-forming region extends well into the planetary-mass regime

Sub-femtosecond electron bunches created by direct laser acceleration in a laser wakefield accelerator with ionization injection

In this work, we will show through three-dimensional particle-in-cell simulations that direct laser acceleration in laser a wakefield accelerator can generate sub-femtosecond electron bunches. Two simulations were done with two laser pulse durations, such that the shortest laser pulse occupies only a fraction of the first bubble, whereas the longer pulse fills the entire first bubble. In the latter case, as the trapped electrons moved forward and interacted with the high intensity region of the laser pulse, micro-bunching occurred naturally, producing 0.5 fs electron bunches. This is not observed in the short pulse simulation.Comment: AAC 201

The phasor-FLIM fingerprints reveal shifts from OXPHOS to enhanced glycolysis in Huntington Disease.

Huntington disease (HD) is an autosomal neurodegenerative disorder caused by the expansion of Polyglutamine (polyQ) in exon 1 of the Huntingtin protein. Glutamine repeats below 36 are considered normal while repeats above 40 lead to HD. Impairment in energy metabolism is a common trend in Huntington pathogenesis; however, this effect is not fully understood. Here, we used the phasor approach and Fluorescence Lifetime Imaging Microscopy (FLIM) to measure changes between free and bound fractions of NADH as a indirect measure of metabolic alteration in living cells. Using Phasor-FLIM, pixel maps of metabolic alteration in HEK293 cell lines and in transgenic Drosophila expressing expanded and unexpanded polyQ HTT exon1 in the eye disc were developed. We found a significant shift towards increased free NADH, indicating an increased glycolytic state for cells and tissues expressing the expanded polyQ compared to unexpanded control. In the nucleus, a further lifetime shift occurs towards higher free NADH suggesting a possible synergism between metabolic dysfunction and transcriptional regulation. Our results indicate that metabolic dysfunction in HD shifts to increased glycolysis leading to oxidative stress and cell death. This powerful label free method can be used to screen native HD tissue samples and for potential drug screening

Ground-runup tests of acoustically treated inlets and fan ducts

Ground performance tests on noise intensity of turbofan engine ducts modified by acoustic lining

The Axiverse Extended: Vacuum Destabilisation, Early Dark Energy and Cosmological Collapse

A model is presented in the philosophy of the "String Axiverse" of Arvanitaki et al (arXiv:0905.4720v2 [hep-th]) that incorporates a coupling of ultralight axions to their corresponding moduli through the mass term. The light fields roll in their potentials at late times and contribute to the dark sector energy densities in the cosmological expansion. The addition of a coupling and extra field greatly enrich the possible phenomenology of the axiverse. There are a number of interesting phases where the axion and modulus components behave as Dark Matter or Dark Energy and can have considerable and distinct effects on the expansion history of the universe by modifying the equation of state in the past or causing possible future collapse of the universe. In future such a coupling may help to alleviate fine tuning problems for cosmological axions. We motivate and present the model, and briefly explore its cosmological consequences numerically.Comment: 13 pages, 17 figures, published in PRD. v3: corrected SUSY interpretation of axion potential scal

HiRes deconvolution of Spitzer infrared images

Spitzer provides unprecedented sensitivity in the infrared (IR), but the spatial resolution is limited by a relatively small aperture (0.85 m) of the primary mirror. In order to maximize the scientific return it is desirable to use processing techniques which make the optimal use of the spatial information in the observations. We have developed a deconvolution technique for Spitzer images. The algorithm, "HiRes" and its implementation has been discussed by Backus et al. in 2005. Here we present examples of Spitzer IR images from the Infrared Array Camera (IRAC) and MIPS, reprocessed using this technique. Examples of HiRes processing include a variety of objects from point sources to complex extended regions. The examples include comparison of Spitzer deconvolved images with high-resolution Keck and Hubble Space Telescope images. HiRes deconvolution improves the visualization of spatial morphology by enhancing resolution (to sub-arcsecond levels in the IRAC bands) and removing the contaminating sidelobes from bright sources. The results thereby represent a significant improvement over previously-published Spitzer images. The benefits of HiRes include (a) sub-arcsec resolution (~0".6-0".8 for IRAC channels); (b) the ability to detect sources below the diffraction-limited confusion level; (c) the ability to separate blended sources, and thereby provide guidance to point-source extraction procedures; (d) an improved ability to show the spatial morphology of resolved sources. We suggest that it is a useful technique to identify features which are interesting enough for follow-up deeper analysis