Experimental prospects for precision observables in e−e+→qqˉe^{-}e^{+}\rightarrow q\bar{q} with q=b,cq=b,c processes at the ILC operating at 250 and 500 GeV of center of mass

Future Higgs Factories will allow the precise study of $e^{-}e^{+}\rightarrow q\bar{q}$ with $q=s,c,b,t$ interactions at different energies, from the Z-pole up to high energies never reached before. In this contribution, we will discuss the experimental prospects for the measurement of differential observables in $e^{-}e^{+}\rightarrow b\bar{b}$ and $e^{-}e^{+}\rightarrow c\bar{c}$ processes at high energies, 250 and 500 GeV, using full simulation samples and the full reconstruction chain from the ILD concept group. These processes call for superb primary and secondary vertex measurements, a high tracking efficiency to correctly measure the vertex charge and excellent hadron identification capabilities using $dE/dx$. This latter aspect will be discussed in detail together with its implementation within the standard flavour tagging tools developed for ILD (LCFI+). In addition, prospects associated with potential improvements using cluster counting techniques instead of traditional $dE/dx$ will be discussed.Comment: This work was carried out in the framework of the ILD concept group. Talk presented at the International Workshop on Future Linear Colliders (LCWS 2023), 15-19 May 2023. C23-05-15.

Transforming triangulations on non planar-surfaces

We consider whether any two triangulations of a polygon or a point set on a non-planar surface with a given metric can be transformed into each other by a sequence of edge flips. The answer is negative in general with some remarkable exceptions, such as polygons on the cylinder, and on the flat torus, and certain configurations of points on the cylinder.Comment: 19 pages, 17 figures. This version has been accepted in the SIAM Journal on Discrete Mathematics. Keywords: Graph of triangulations, triangulations on surfaces, triangulations of polygons, edge fli

Using historical lesion volume data in the design of a new phase II clinical trial in acute stroke

<p><b>Background and Purpose:</b> Clinical research into the treatment of acute stroke is complicated, is costly, and has often been unsuccessful. Developments in imaging technology based on computed tomography and magnetic resonance imaging scans offer opportunities for screening experimental therapies during phase II testing so as to deliver only the most promising interventions to phase III. We discuss the design and the appropriate sample size for phase II studies in stroke based on lesion volume.</p> <p><b>Methods:</b> Determination of the relation between analyses of lesion volumes and of neurologic outcomes is illustrated using data from placebo trial patients from the Virtual International Stroke Trials Archive. The size of an effect on lesion volume that would lead to a clinically relevant treatment effect in terms of a measure, such as modified Rankin score (mRS), is found. The sample size to detect that magnitude of effect on lesion volume is then calculated. Simulation is used to evaluate different criteria for proceeding from phase II to phase III.</p> <p><b>Results:</b> The odds ratios for mRS correspond roughly to the square root of odds ratios for lesion volume, implying that for equivalent power specifications, sample sizes based on lesion volumes should be about one fourth of those based on mRS. Relaxation of power requirements, appropriate for phase II, lead to further sample size reductions. For example, a phase III trial comparing a novel treatment with placebo with a total sample size of 1518 patients might be motivated from a phase II trial of 126 patients comparing the same 2 treatment arms.</p> <p><b>Discussion:</b> Definitive phase III trials in stroke should aim to demonstrate significant effects of treatment on clinical outcomes. However, more direct outcomes such as lesion volume can be useful in phase II for determining whether such phase III trials should be undertaken in the first place.</p&gt

Quality Improvement in Sweet Red Wines Through an Alternative Grape-Drying System

A sensorial analysis was undertaken and the colour parameters and phenolic profile were measured fortwo types of Andalusian sweet red wines. Two wines types were studied, i.e. commercial and alternativewines elaborated with musts from grapes obtained by traditional sun drying and by chamber dryingunder controlled temperatures respectively. Results show that the alternative wines obtained in this studywere analytically closer to typical red wines in their lower concentration of browning compounds, a highcontribution of red and blue colour, and hence having a more suitable hue than the traditional sweetwines. Furthermore, the alternative wines were the richest in monomeric anthocyanins, flavan-3-ols andflavonols, which give these wines their antioxidant properties. Their sensorial characteristics were acceptedby consumers, which means that the alternative grape-drying system improves the quality of sweet redwines relative to those obtained by the traditional method