Comment on "1/f noise in the Bak-Sneppen model"

Contrary to the recently published results by Daerden and Vanderzande [Phys. Rev. E 53, 4723 (1996)], we show that the time correlation function in the random-neighbor version of the Bak-Sneppen model can be well approximated by an exponential giving rise to a 1/f2 power spectrum.Comment: 2 pages, 2 figure

Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling

AbstractThe generation of excessive amounts of reactive oxygen species (ROS) leads to cellular oxidative stress that underlies a variety of forms of hepatocyte injury and death including that from alcohol. Although ROS can induce cell damage through direct effects on cellular macromolecules, the injurious effects of ROS are mediated largely through changes in signal transduction pathways such as the mitogen-activated protein kinase c-Jun N-terminal kinase (JNK). In response to alcohol, hepatocytes have increased levels of the enzyme cytochrome P450 2E1 (CYP2E1) which generates an oxidant stress that promotes the development of alcoholic steatosis and liver injury. These effects are mediated in large part through overactivation of JNK that alters cell death pathways. Targeting the JNK pathway or its downstream effectors may be a useful therapeutic approach to the oxidative stress generated by CYP2E1 in alcoholic liver disease

Crop expansion and conservation priorities in tropical countries

Expansion of cropland in tropical countries is one of the principal causes of biodiversity loss, and threatens to undermine progress towards meeting the Aichi Biodiversity Targets. To understand this threat better, we analysed data on crop distribution and expansion in 128 tropical countries, assessed changes in area of the main crops and mapped overlaps between conservation priorities and cultivation potential. Rice was the single crop grown over the largest area, especially in tropical forest biomes. Cropland in tropical countries expanded by c. 48,000 km2 per year from 1999–2008. The countries which added the greatest area of new cropland were Nigeria, Indonesia, Ethiopia, Sudan and Brazil. Soybeans and maize are the crops which expanded most in absolute area. Other crops with large increases included rice, sorghum, oil palm, beans, sugar cane, cow peas, wheat and cassava. Areas of high cultivation potential—while bearing in mind that political and socio-economic conditions can be as influential as biophysical ones—may be vulnerable to conversion in the future. These include some priority areas for biodiversity conservation in tropical countries (e.g., Frontier Forests and High Biodiversity Wilderness Areas), which have previously been identified as having ‘low vulnerability’, in particular in central Africa and northern Australia. There are also many other smaller areas which are important for biodiversity and which have high cultivation potential (e.g., in the fringes of the Amazon basin, in the Paraguayan Chaco, and in the savanna woodlands of the Sahel and East Africa). We highlight the urgent need for more effective sustainability standards and policies addressing both production and consumption of tropical commodities, including robust land-use planning in agricultural frontiers, establishment of new protected areas or REDD+ projects in places agriculture has not yet reached, and reduction or elimination of incentives for land-demanding bioenergy feedstock

Disk Dominated States of 4U 1957+11: Chandra, XMM, and RXTE Observations of Ostensibly the Most Rapidly Spinning Galactic Black Hole

We present simultaneous Chandra-HETG and RXTE observations of a moderate flux `soft state' of the black hole candidate 4U1957+11. These spectra, having a minimally discernible hard X-ray excess, are an excellent test of modern disk atmosphere models that include the effects of black hole spin. The HETG data show that the soft disk spectrum is only very mildly absorbed with N_H =1-2 X 10^{21} cm^-2. These data additionally reveal 13.449 A NeIX absorption consistent with the warm/hot phase of the interstellar medium. The fitted disk model implies a highly inclined disk around a low mass black hole rapidly rotating with normalized spin a*~1. We show, however, that pure Schwarzschild black hole models describe the data extremely well, albeit with large disk atmosphere ``color-correction'' factors. Standard color-correction factors can be attained if one additionally incorporates mild Comptonization. We find that the Chandra observations do not uniquely determine spin. Similarly, XMM/RXTE observations, taken only six weeks later, are equally unconstraining. This lack of constraint is partly driven by the unknown mass and unknown distance of 4U1957+11; however, it is also driven by the limited bandpass of Chandra and XMM. We therefore present a series of 48 RXTE observations taken over the span of several years and at different brightness/hardness levels. These data prefer a spin of a*~1, even when including a mild Comptonization component; however, they also show evolution of the disk atmosphere color-correction factors. If the rapid spin models with standard atmosphere color-correction factors of h_d=1.7 are to be believed, then the RXTE observations predict that 4U1957+11 can range from a 3 M_sun black hole at 10 kpc with a*~0.83 to a 16 M_sun black hole at 22 kpc with a* ~ 1, with the latter being statistically preferred.Comment: 16 pages (emulateapj style). Accepted for Publication in the Astrophysical Journa

Mycobacterium tuberculosis evasion of Guanylate Binding Protein-mediated host defense in mice requires the ESX1 secretion system [preprint]

Cell-intrinsic immune mechanisms control intracellular pathogens that infect eukaryotes. The intracellular pathogen Mycobacterium tuberculosis (Mtb) evolved to withstand cell-autonomous immunity to cause persistent infections and disease. A potent inducer of cell-autonomous immunity is the lymphocyte-derived cytokine IFNγ. While the production of IFNγ by T cells is essential to protect against Mtb, it is not capable of fully eradicating Mtb infection. This suggests that Mtb evades a subset of IFNγ-mediated antimicrobial responses, yet what mechanisms Mtb resists remains unclear. The IFNγ-inducible Guanylate binding proteins (GBPs) are key host defense proteins able to control infections with intracellular pathogens. GBPs were previously shown to directly restrict Mycobacterium bovis BCG yet their role during Mtb infection has remained unknown. Here, we examine the importance of a cluster of five GBPs on mouse chromosome 3 in controlling Mycobacterial infection. While M. bovis BCG is directly restricted by GBPs, we find that the GBPs on chromosome 3 do not contribute to the control of Mtb replication or the associated host response to infection. The differential effects of GBPs during Mtb versus M. bovis BCG infection is at least partially explained by the absence of the ESX1 secretion system from M. bovis BCG, since Mtb mutants lacking the ESX1 secretion system become similarly susceptible to GBP-mediated immune defense. Therefore, this specific genetic interaction between the murine host and Mycobacteria reveals a novel function for the ESX1 virulence system in the evasion of GBP-mediated immunity

Low Reynolds number hydrodynamics of asymmetric, oscillating dumbbell pairs

Active dumbbell suspensions constitute one of the simplest model system for collective swimming at low Reynolds number. Generalizing recent work, we derive and analyze stroke-averaged equations of motion that capture the effective hydrodynamic far-field interaction between two oscillating, asymmetric dumbbells in three space dimensions. Time-averaged equations of motion, as those presented in this paper, not only yield a considerable speed-up in numerical simulations, they may also serve as a starting point when deriving continuum equations for the macroscopic dynamics of multi-swimmer suspensions. The specific model discussed here appears to be particularly useful in this context, since it allows one to investigate how the collective macroscopic behavior is affected by changes in the microscopic symmetry of individual swimmers.Comment: 10 pages, to appear in EPJ Special Topic

Correlated radio--X-ray variability of Galactic Black Holes: A radio--X-ray flare in Cygnus X-1

We report on the first detection of a quasi-simultaneous radio-X-ray flare of Cygnus X-1. The detection was made on 2005 April 16 with pointed observations by the Rossi X-ray Timing Explorer and the Ryle telescope, during a phase where the black hole candidate was close to a transition from the its soft into its hard state. The radio flare lagged the X-rays by approximately 7 minutes, peaking at 3:20 hours barycentric time (TDB 2453476.63864). We discuss this lag in the context of models explaining such flaring events as the ejection of electron bubbles emitting synchrotron radiation.Comment: 4 pages, 4 figure