545 research outputs found
Charge and Spin Currents Generated by Dynamical Spins
We demonstrate theoretically that a charge current and a spin current are
generated by spin dynamics in the presence of spin-orbit interaction in the
perturbative regime. We consider a general spin-orbit interaction including the
spatially inhomogeneous case. Spin current due to spin damping is identified as
one origin of generated charge current, but other contributions exist, such as
the one due to an induced conservative field and the one arising from the
inhomogeneity of spin-orbit interaction.Comment: 14 pages, 4 figure
Conductance fluctuations in the presence of spin scattering
Electron transport through disordered systems that include spin scatterers is
studied numerically. We consider three kinds of magnetic impurities: the Ising,
the XY and the Heisenberg. By extending the transfer matrix method to include
the spin degree of freedom, the two terminal conductance is calculated. The
variance of conductance is halved as the number of spin components of the
magnetic impurities increases. Application of the Zeeman field in the lead
causes a further halving of the variance under certain conditions.Comment: to be published in Phys. Rev.
Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer
FLAURA ClinicalTrials.gov number, NCT02296125BACKGROUND:
Osimertinib is an oral, third-generation, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that selectively inhibits both EGFR-TKI-sensitizing and EGFR T790M resistance mutations. We compared osimertinib with standard EGFR-TKIs in patients with previously untreated, EGFR mutation-positive advanced non-small-cell lung cancer (NSCLC).
METHODS:
In this double-blind, phase 3 trial, we randomly assigned 556 patients with previously untreated, EGFR mutation-positive (exon 19 deletion or L858R) advanced NSCLC in a 1:1 ratio to receive either osimertinib (at a dose of 80 mg once daily) or a standard EGFR-TKI (gefitinib at a dose of 250 mg once daily or erlotinib at a dose of 150 mg once daily). The primary end point was investigator-assessed progression-free survival.
RESULTS:
The median progression-free survival was significantly longer with osimertinib than with standard EGFR-TKIs (18.9 months vs. 10.2 months; hazard ratio for disease progression or death, 0.46; 95% confidence interval [CI], 0.37 to 0.57; P<0.001). The objective response rate was similar in the two groups: 80% with osimertinib and 76% with standard EGFR-TKIs (odds ratio, 1.27; 95% CI, 0.85 to 1.90; P=0.24). The median duration of response was 17.2 months (95% CI, 13.8 to 22.0) with osimertinib versus 8.5 months (95% CI, 7.3 to 9.8) with standard EGFR-TKIs. Data on overall survival were immature at the interim analysis (25% maturity). The survival rate at 18 months was 83% (95% CI, 78 to 87) with osimertinib and 71% (95% CI, 65 to 76) with standard EGFR-TKIs (hazard ratio for death, 0.63; 95% CI, 0.45 to 0.88; P=0.007 [nonsignificant in the interim analysis]). Adverse events of grade 3 or higher were less frequent with osimertinib than with standard EGFR-TKIs (34% vs. 45%).
CONCLUSIONS:
Osimertinib showed efficacy superior to that of standard EGFR-TKIs in the first-line treatment of EGFR mutation-positive advanced NSCLC, with a similar safety profile and lower rates of serious adverse events. (Funded by AstraZeneca; FLAURA ClinicalTrials.gov number, NCT02296125 .).info:eu-repo/semantics/publishedVersio
Effective magnetization damping for a dynamical spin texture in metallic ferromagnet
An additional magnetization damping for an inhomogeneous spin texture in metallic ferromagnets is calculated
on the basis of the s–d exchange model. The effect of conduction electrons on the magnetization dynamics is
accounted for the case of slowly varying spin texture within adiabatic approximation by using a coordinate transformation
to the local quantization axis. The moving magnetic vortex in a circular nanodot made of permalloy is
considered as an example. The dependence of the damping on the dot geometrical sizes is obtained. It is found
that the additional damping can reach up to 50% of magnitude of the phenomenological Gilbert damping in the
Landau–Lifshitz equation of magnetization motion and should be taken into account for any inhomogeneous
spin texture dynamics in ferromagnetic metals
Charge and Spin Transport in Magnetic Tunnel Junctions: Microscopic Theory
We study the charge and spin currents passing through a magnetic tunnel
junction (MTJ) on the basis of a tight-binding model. The currents are
evaluated perturbatively with respect to the tunnel Hamiltonian. The charge
current has the form , where and denote the directions of
the magnetization in the free layer and fixed layer, respectively. The constant
vanishes when one or both layers are insulators, {while the constant
disappears when both layers are insulators or the same ferromagnets.} The first
term in the expression for charge current represents dissipation driven by the
effective electric field induced by the dynamic magnetization. In addition,
from an investigation of the spin current, we obtain the microscopic expression
for the enhanced Gilbert damping constant . We show that
is proportional to the tunnel conductance and depends on the
bias voltage.Comment: 13 pages, 1 figure, accepted for publication in Journal of the
Physical Society of Japa
Spin Seebeck insulator
Thermoelectric generation is an essential function of future energy-saving
technologies. However, this generation has been an exclusive feature of
electric conductors, a situation which inflicts a heavy toll on its
application; a conduction electron often becomes a nuisance in thermal design
of devices. Here we report electric-voltage generation from heat flowing in an
insulator. We reveal that, despite the absence of conduction electrons, a
magnetic insulator LaY2Fe5O12 converts a heat flow into spin voltage. Attached
Pt films transform this spin voltage into electric voltage by the inverse spin
Hall effect. The experimental results require us to introduce thermally
activated interface spin exchange between LaY2Fe5O12 and Pt. Our findings
extend the range of potential materials for thermoelectric applications and
provide a crucial piece of information for understanding the physics of the
spin Seebeck effect.Comment: 19 pages, 5 figures (including supplementary information
Perturbation theory of the dynamic inverse spin Hall effect with charge conservation
We present gauge-invariant theory of the dynamic inverse spin Hall effect
driven by the spin--orbit interaction in metallic systems. Charge conservation
is imposed diagrammatically by including vertex corrections. We show the charge
current is induced by an effective electric field that is proportional to the
spin current pumped by the magnetization dynamics. The result is consistent
with recent experiments.Comment: 16pages, 5figure
Spin Caloritronics
This is a brief overview of the state of the art of spin caloritronics, the
science and technology of controlling heat currents by the electron spin degree
of freedom (and vice versa).Comment: To be published in "Spin Current", edited by S. Maekawa, E. Saitoh,
S. Valenzuela and Y. Kimura, Oxford University Pres
Characteristics and outcomes of patients with advanced non-small-cell lung cancer who declined to participate in randomised clinical chemotherapy trials
There are inadequate data on the outcomes of patients who declined to participate in randomised clinical trials as compared with those of participants. We retrospectively reviewed the patient characteristics and treatment outcomes of both participants and non-participants in the two randomised trials for chemotherapy-naive advanced non-small-cell lung cancer. Trial 1 compared four platinum-based combination regimens. Trial 2 compared two sequences of carboplatin plus paclitaxel and gefitinib therapies. Nineteen of 119 (16%) and 153 (37%) patients declined to participate in Trials 1 and 2, respectively. Among the background patient characteristics, the only variable associated with trial participation or declining was the patients' attending physicians (P<0.001). Important differences were not observed in the clinical outcomes between participants and non-participants, for whom the response rates were 30.6 vs 34.2% and the median survival times were 489 vs 461 days, respectively. The hazard ratio for overall survival, adjusted for other confounding variables, was 0.965 (95% confidence interval: 0.73–1.28). In conclusion, there was no evidence to suggest any difference in the characteristics and clinical outcomes between participants and non-participants. Trial designs and the doctor–patient relationship may have an impact on the patient accrual to randomised trials
- …