Occupational therapy for stroke patients - A systematic review

Ergotherapie helpt patiënten die een beroerte gehad hebben bij het revalideren. Ook mensen met reumatoïde artritis (RA) hebben baat bij ergotherapie, onder andere door instructie over gewrichtsbeschermende maatregelen. Dit blijkt uit NIVEL onderzoek in opdracht van het Reumafonds en het College voor Zorgverzekeringen (CvZ). NIVEL onderzoeker Esther Steultjens vergeleek, schiftte en analyseerde de resultaten van al het onderzoek naar de effectiviteit van ergotherapie bij Reumatoïde Artritis (37 wetenschappelijke studies) en beroertes (32 wetenschappelijke studies) van de afgelopen 40 jaar. De resultaten zijn gebaseerd op een klein aantal, omdat de meeste gevonden studies van beperkte kwaliteit zijn. Beroerte Steultjens concludeert dat bij mensen die een beroerte gehad hebben ergotherapie de sociale participatie en de zelfredzaamheid bevordert. Vaardigheidstraining leidt ook tot enige verbetering van de zelfredzaamheid. Ze vond onvoldoende bewijs voor het nut van spalken om de spierspanning te verminderen. Per jaar krijgen ongeveer 32.000 mensen in Nederland een beroerte. Na een jaar heeft 66% van de overlevenden problemen met zelfstandig functioneren, driekwart van de overlevenden heeft problemen met een zinvolle tijdsbesteding. Steultjens: "Uit dit onderzoek blijkt dat ergotherapie een belangrijke rol heeft in de multidisciplinaire aanpak van de revalidatie van mensen met een beroerte." Reumatoïde artritis (RA) Steultjens concludeert dat er bewijs is dat ergotherapie bij mensen met RA een positief effect heeft op het kunnen verrichten van dagelijkse activiteiten en op het verlichten van pijn. Vooral instructies over het nemen van gewrichtsbeschermende maatregelen hebben invloed op het functioneren. Het spalken van aangedane ledematen lijkt de pijn te verminderen, ook al kan het de patiënt hinderen bij het bewegen. RA is een chronische ontsteking van de gewrichten die het dagelijks functioneren van ongeveer 145.000 Nederlanders beperkt. Ergotherapie is een vorm van paramedisch handelen die zich richt op het verbeteren van het dagelijks functioneren. De ergotherapeutische behandeling streeft ernaar het uitvoeren van taken te vergemakkelijken door met de patiënten sommige dagelijkse activiteiten te trainen en ze voor andere compensatiestrategieën aan te leren. Andere onderdelen van de ergotherapeutische behandeling zijn het geven van leefstijladviezen (zoals gewrichtsbeschermende of energiebesparende maatregelen) en advies/instructie over hulpmiddelen en spalktherapie. Het onderzoek is opgezet en uitgevoerd volgens de richtlijnen van de Cochrane Collaboration. Dit is een internationale organisatie die het maken, actualiseren en verspreiden van de resultaten van systematisch literatuuronderzoek naar de effecten van gezondheidszorg tot doel heeft. Arthritis Care & Research, Volume 47, Issue 6, 2002 Occupational therapy for rheumatoid arthritis: A systematic review Esther M. J. Steultjens , Joost Dekker, Lex M. Bouter, Dirkjan van Schaardenburg, Marie-Antoinette H. van Kuyk, Cornelia H. M. van den Ende Arthritis Care & Research is het Official Journal of the Association of Rheumatology Health Professionals

Long survival of primary diffuse leptomeningeal gliomatosis following radiotherapy and temozolomide: case report and literature review

<p>Abstract</p> <p>Objective</p> <p>Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare neoplasm with a short survival time of a few months. there is currently no standardized therapeutic approach for PDLG.</p> <p>Materials and methods</p> <p>We report on a 53-year-old male patient who presented with epileptic seizures, gait disturbance, paraparesis and sensory deficits in the dermatomes T8-10.</p> <p>Results</p> <p>Magnetic resonance imaging (MRI) revealing numerous spinal and cranial gadolinium-enhancing nodules in the meninges and histopathology led us to diagnose primary diffuse leptomeningeal gliomatosis with WHO grade III astrocytic cells. Consecutively, the patient underwent craniospinal radiotherapy (30 Gy) and 11 sequential cycles of temozolomide. This regimen led to partial tumor regression. Thirteen months later, spinal MRI revealed tumor progression. Second-line chemotherapy with 5 cycles of irinotecan and bevacizumab did not prevent further clinical deterioration. The patient died twenty-two months after diagnosis, being the longest survival time described thus far with respect to PDLG consisting of astrocytic tumor cells.</p> <p>Conclusions</p> <p>Radiochemotherapy including temozolomide, as established standard therapy for brain malignant astrocytomas, might be valid as a basic therapeutic strategy for this PDLG subtype.</p

Foreseeing the future of mutualistic communities beyond collapse

International audienc

Predictors of undergoing multivisceral resection, margin status and survival in Dutch patients with locally advanced colorectal cancer

Background: The aim of this nationwide observational study was to evaluate factors associated with multivisceral resection (MVR), margin status and overall survival in locally advanced colorectal cancer (CRC). Material and methods: Patients with (y)pT4, cM0 CRC between 2006 and 2017 were selected from the Netherlands Cancer Registry. Cox-proportional hazards modelling was used for survival analysis, stratified for T4a and T4b. Annual hospital volume cut-off was 75 for colon and 40 for rectal resections. Results: A total of 11.930 patients were included and 2410 patients (20.2%) underwent MVR. Factors associated with MVR for colon and rectal cancer besides cT4 category were more recent diagnosis (OR 3.61, CI 95% 3.06–4.25 (colon) and OR 2.72, CI 95% 1.82–4.08 (rectum)) and high hospital volume (OR 1.20, CI 95% 1.05–1.38 (colon) and OR 2.17, CI 95% 1.55–3.04 (rectum)). Patients ≥70 year were less likely to undergo MVR for colon cancer (OR 0.80, 95% CI 0.70–0.90). Risk factors for incomplete resection were cT4 (OR 3.08, CI 95% 2.35–4.04 (colon) and OR 1.82, CI 95% 1.13–2.94 (rectum)) and poor/undifferentiated tumors (OR 1.41, CI 95% 1.14–1.72 (colon) and OR 1.69, CI 95% 1.05–2.74 (rectum)). More recent diagnosis was independently associated with less incomplete resections in colon cancer (OR 0.58, CI 95% 0.40–0.76). Independent predictors of survival were age, resection margin, nodal status and adjuvant chemotherapy, but not MVR. Conclusion: Treatment of locally advanced CRC with MVR at population level was influenced by year of diagnosis and hospital volume. Margin status in colon cancer improved substantially over time.</p

Predictors of undergoing multivisceral resection, margin status and survival in Dutch patients with locally advanced colorectal cancer

Background: The aim of this nationwide observational study was to evaluate factors associated with multivisceral resection (MVR), margin status and overall survival in locally advanced colorectal cancer (CRC). Material and methods: Patients with (y)pT4, cM0 CRC between 2006 and 2017 were selected from the Netherlands Cancer Registry. Cox-proportional hazards modelling was used for survival analysis, stratified for T4a and T4b. Annual hospital volume cut-off was 75 for colon and 40 for rectal resections. Results: A total of 11.930 patients were included and 2410 patients (20.2%) underwent MVR. Factors associated with MVR for colon and rectal cancer besides cT4 category were more recent diagnosis (OR 3.61, CI 95% 3.06–4.25 (colon) and OR 2.72, CI 95% 1.82–4.08 (rectum)) and high hospital volume (OR 1.20, CI 95% 1.05–1.38 (colon) and OR 2.17, CI 95% 1.55–3.04 (rectum)). Patients ≥70 year were less likely to undergo MVR for colon cancer (OR 0.80, 95% CI 0.70–0.90). Risk factors for incomplete resection were cT4 (OR 3.08, CI 95% 2.35–4.04 (colon) and OR 1.82, CI 95% 1.13–2.94 (rectum)) and poor/undifferentiated tumors (OR 1.41, CI 95% 1.14–1.72 (colon) and OR 1.69, CI 95% 1.05–2.74 (rectum)). More recent diagnosis was independently associated with less incomplete resections in colon cancer (OR 0.58, CI 95% 0.40–0.76). Independent predictors of survival were age, resection margin, nodal status and adjuvant chemotherapy, but not MVR. Conclusion: Treatment of locally advanced CRC with MVR at population level was influenced by year of diagnosis and hospital volume. Margin status in colon cancer improved substantially over time.</p

Radiotherapy for patients with ledderhose disease:long-term effects, side effects and patient-rated outcome

BACKGROUND: The purpose of this study was to investigate the long-term effects of radiotherapy for patients with Ledderhose disease. METHODS: Questionnaires were sent to all patients with Ledderhose disease who had been treated with radiotherapy at our centre between 2008 and 2017 and who consented to participate. Radiotherapy was performed with orthovolt or electrons in two separate courses of five daily fractions of 3 Gy. The questionnaires addressed items such as pain from Ledderhose disease (Brief Pain Inventory), quality of life (EURO-QOL-5D-5L), long-term side effects, and patients' levels of satisfaction with the effect of treatment. Descriptive statistics and non-parametric tests were used to analyse the results. RESULTS: A total of 102 feet were irradiated in 67 patients (28 men, 39 women). Radiotherapy resulted in significant pain reduction: the mean pain score prior to radiotherapy, collected retrospectively, was 5.7 and 1.7 at time of assessment (p-value<0.001). The following pain response scores were reported: progressive pain (0%), no change (22%; 22 feet), partial pain response (37%; 38 feet) and complete pain response (absence of pain) (41%; 42 feet). Seventy-eight percent of patients were satisfied with the treatment effect and 57% did not consider radiotherapy burdensome. The scores for societal perspective (0.856) and patients' perspective on quality of life (82.3) were each comparable to the reference values from the Dutch population in the same age category (0.857 and 80.6, respectively). The most commonly reported residual long-term side effect was dryness of the skin (n=10; 15%). CONCLUSION: Radiotherapy for Ledderhose disease results in long-term pain reduction in the majority of patients and has limited side effects. The treatment is well tolerated, patients feel satisfied, and quality of life is comparable to the reference population