141 research outputs found
Robustness of the rule-learning effect in 7-month-old infants: A close, multicenter replication of Marcus et al. (1999)
Failure to release iron from transferrin in a Chinese hamster ovary cell mutant pleiotropically defective in endocytosis.
Robustness of the rule‐learning effect in 7‐month‐old infants: a close, multicenter replication of Marcus et al. (1999)
NWO401.18.044Theoretical and Experimental Linguistic
The development of gaze following in monolingual and bilingual infants: A multi‐laboratory study
Nanobiopolymer for Direct Targeting and Inhibition of EGFR Expression in Triple Negative Breast Cancer
Treatment options for triple negative breast cancer (TNBC) are generally limited to cytotoxic chemotherapy. Recently, anti-epidermal growth factor receptor (EGFR) therapy has been introduced for TNBC patients. We engineered a novel nanobioconjugate based on a poly(β-L-malic acid) (PMLA) nanoplatform for TNBC treatment. The nanobioconjugate carries anti-tumor nucleosome-specific monoclonal antibody (mAb) 2C5 to target breast cancer cells, anti-mouse transferrin receptor (TfR) antibody for drug delivery through the host endothelial system, and Morpholino antisense oligonucleotide (AON) to inhibit EGFR synthesis. The nanobioconjugates variants were: (1) P (BioPolymer) with AON, 2C5 and anti-TfR for tumor endothelial and cancer cell targeting, and EGFR suppression (P/AON/2C5/TfR), and (2) P with AON and 2C5 (P/AON/2C5). Controls included (3) P with 2C5 but without AON (P/2C5), (4) PBS, and (5) P with PEG and leucine ester (LOEt) for endosomal escape (P/mPEG/LOEt). Drugs were injected intravenously to MDA-MB-468 TNBC bearing mice. Tissue accumulation of injected nanobioconjugates labeled with Alexa Fluor 680 was examined by Xenogen IVIS 200 (live imaging) and confocal microscopy of tissue sections. Levels of EGFR, phosphorylated and total Akt in tumor samples were detected by western blotting
Een opgraving met beperkingen van de resten van een Middeleeuwse burcht aan de Herman Kuijkstraat 28-32 te Geldermalsen
Lit.opg., bijl
Inventariserend veldonderzoek door middel van proefsleuven in het plangebied Zundert - verlengde Hofdreef
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