Droplet impingement and wetting behavior on a chemically heterogeneous surface in the Beyond-Cassie-Baxter regime

Peer reviewedPostprin

Deformation and breakup of single drop in laminar and transitional jet flows

The authors gratefully acknowledge the financial support from the National Key R&D Program of China (2017YFB0306701), National Natural Science Foundation of China (No.21676007)，the Fundamental Research Funds for the Central Universities (XK1802-1), and Scientific Research and Technology Development Projects of China National Petroleum Corporation (No. 2016B-2605).Peer reviewedPostprin

Direction of Arrival Estimation and Sensor Array Error Calibration Based on Blind Signal Separation

We consider estimating the direction of arrival (DOA) in the presence of sensor array error. In the proposed method, a blind signal separation method, the Joint Approximation and Diagonalization of Eigenmatrices (JADE) algorithm, is implemented to separate the signal vector and the mixing matrix consisting of the array manifold matrix and the sensor array error matrix. Based on a new mixing matrix and the reconstruction of the array output vector of each individual signal, we propose a novel DOA estimation method and sensor array error calibration procedure. This method is independent of array phase errors and performs well against difference of SNR of signals. Numerical simulations verify the effectiveness of the proposed method

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

Medulloblastoma is the most common malignant brain tumor of childhood. Despite numerous advances, clinical challenges range from recurrent and progressive disease to long-term toxicities in survivors. The lack of more effective, less toxic therapies results from our limited understanding of medulloblastoma growth. Although TP53 is the most commonly altered gene in cancers, it is rarely mutated in medulloblastoma. Accumulating evidence, however, indicates that TP53 pathways are disrupted in medulloblastoma. Wild-typep53-induced phosphatase 1 (WIP1 or PPM1D) encodes a negative regulator of p53. WIP1 amplification (17q22-q23) and its overexpression have been reported in diverse cancer types. We examined primary medulloblastoma specimens and cell lines, and detected WIP1 copy gain and amplification prevalent among but not exclusively in the tumors with 17q gain and isochromosome 17q (i17q), which are among the most common cytogenetic lesions in medulloblastoma. WIP1 RNA levels were significantly higher in the tumors with 17q gain or i17q. Immunoblots confirmed significant WIP1 protein in primary tumors, generally higher in those with 17q gain or i17q. Under basal growth conditions and in response to the chemotherapeutic agent, etoposide, WIP1 antagonized p53-mediated apoptosis in medulloblastoma cell lines. These results indicate that medulloblastoma express significant levels of WIP1 that modulate genotoxic responsiveness by negatively regulating p53

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

The Wild-type p53-induced phosphatase 1, Wip1 (or PPM1D), is unusual in that it is a serine/threonine phosphatase with oncogenic activity. A member of the type 2C phosphatases (PP2Cδ), Wip1 has been shown to be amplified and overexpressed in multiple human cancer types, including breast and ovarian carcinomas. In rodent primary fibroblast transformation assays, Wip1 cooperates with known oncogenes to induce transformed foci. The recent identification of target proteins that are dephosphorylated by Wip1 has provided mechanistic insights into its oncogenic functions. Wip1 acts as a homeostatic regulator of the DNA damage response by dephosphorylating proteins that are substrates of both ATM and ATR, important DNA damage sensor kinases. Wip1 also suppresses the activity of multiple tumor suppressors, including p53, ATM, p16INK4a and ARF. We present evidence that the suppression of p53, p38 MAP kinase, and ATM/ATR signaling pathways by Wip1 are important components of its oncogenicity when it is amplified and overexpressed in human cancers

The design and implementation of a high speed parallel optical receiver module based on passive coupling

An advanced structure of passive optical coupling for the application of optical interconnect with the high coupling efficiency and the high alignment precision was proposed, and a12-channel high-speed parallel optical receiver module based on this advanced coupling technique was designed and fabricated using an850nm GaAs photoelectric detector(PD) array and a fiber array. The error amount of coupling was less than1μm and the coupling efficiency was more than80 percent. The optical signals was directly coupled into PD array through a fiber array. We got a wide open eye diagram with data rate of3.318 Gbit/s for each channel and the total data rate of40 Gbit/s from the receiver module. Compared with active optical coupling, the passive optical coupling simplified the coupling process and enhanced the work efficiency. It's suited for large-scale production