Profile of allergy-related articles in the primary academic publication for UK General Practitioners

Background: Concern is often expressed about primary health care professionals’ lack of knowledge about allergies, particularly diagnostic testing and the management of atopic disorders. Limited training opportunities in allergy have been documented in both undergraduate and postgraduate education. The British Journal of General Practice is the leading UK-based Family Practice journal, it has a strong clinical focus. The BJGP was established in 1953. It is a high quality journal and is the world’s 2nd most highly cited journal of general practice and primary care. Methods: Keyword search of bjgp.org. Terms used were ‘allergy’, ‘allergies’, ‘allergic’, ‘rhinitis’, ‘urticaria’, ‘eczema’, ‘angioedema’. All titles and articles from 1953 to 2013 were searched. Full copies of relevant publications were downloaded and variables extracted, including title, year of publication, type of article, clinical focus. As a comparator a similar search was conducted for articles about asthma using the search term ‘asthma’. Results: 41 allergy-related articles were identified in the 60 years since the journal was launched. In the same time period there were 147 articles about asthma. In 31 of the 60 years reviewed there were no articles at all about any allergy-related topic. The focus of the articles published were eczema (6), food allergy (6), rhinoconjunctivitis (5), anaphylaxis (4), urticaria (1). There were no articles on angioedema. Some articles addressed multiple atopic disorders, eg ‘Allergic diseases in the elderly’ (1968), ‘Allergic disorders amongst horticultural, agricultural and forestry workers’ [letter] (1965). Conclusions: Allergy has a low profile in the British Journal of General Practice. This low profile persists despite the increasing prevalence of atopic disorders and major national reports highlighting the need for better care of the allergic patient in primary care. Our exploratory study highlights a missed opportunity to educate and inform General Practitioners about allergy through this widely circulated journal. Further work is needed to understand better why so few articles on allergy are published in the BJGP. If the paucity of publications reflects the number of articles submitted then BSACI members interested in informing and improving allergy management in General Practice should include the BJGP on their list of target journals. Where next: To share these observations with the Editor of the BJGP to understand whether they reflect editorial policy or lack of submissions from clinicians and researchers with expertise in allergy. To work with the BJGP to identify collaborative initiatives to address the serious mismatch between the prevalence of allergy in the clinical consultation and the number of allergy- related articles in the literature for GPs

The JCMT dense gas survey of the Perseus Molecular Cloud

We present the results of a large-scale survey of the very dense gas in the Perseus molecular cloud using HCO+ and HCN (J = 4 - 3) transitions. We have used this emission to trace the structure and kinematics of gas found in pre- and protostellar cores, as well as in outflows. We compare the HCO+/HCN data, highlighting regions where there is a marked discrepancy in the spectra of the two emission lines. We use the HCO+ to identify positively protostellar outflows and their driving sources, and present a statistical analysis of the outflow properties that we derive from this tracer. We find that the relations we calculate between the HCO+ outflow driving force and the Menv and Lbol of the driving source are comparable to those obtained from similar outflow analyses using 12CO, indicating that the two molecules give reliable estimates of outflow properties. We also compare the HCO+ and the HCN in the outflows, and find that the HCN traces only the most energetic outflows, the majority of which are driven by young Class 0 sources. We analyse the abundances of HCN and HCO+ in the particular case of the IRAS 2A outflows, and find that the HCN is much more enhanced than the HCO+ in the outflow lobes. We suggest that this is indicative of shock-enhancement of HCN along the length of the outflow; this process is not so evident for HCO+, which is largely confined to the outflow base.Comment: 25 pages, 14 figures, 9 table

JMASM36: Nine Pseudo R^2 Indices for Binary Logistic Regression Models (SPSS)

This syntax program is an applied complement to Veall and Zimmermann (1994), Menard (2000), and Smith and McKenna (2013) and produces nine pseudo R2 indices, not readily accessible in statistical software such as SPSS, which are used to describe the results from binary logistic regression analyses

Logistic Regression Under Sparse Data Conditions

The impact of sparse data conditions was examined among one or more predictor variables in logistic regression and assessed the effectiveness of the Firth (1993) procedure in reducing potential parameter estimation bias. Results indicated sparseness in binary predictors introduces bias that is substantial with small sample sizes, and the Firth procedure can effectively correct this bias

Routine data linkage to identify and monitor diabetes in clozapine-treated patients with schizophrenia

No abstract available

The MAREDAT global database of high performance liquid chromatography marine pigment measurements

A global pigment database consisting of 35 634 pigment suites measured by high performance liquid chromatography was assembled in support of the MARine Ecosytem DATa (MAREDAT) initiative. These data originate from 136 field surveys within the global ocean, were solicited from investigators and databases, compiled, and then quality controlled. Nearly one quarter of the data originates from the Laboratoire d\u27Oceanographie de Villefranche (LOV), with an additional 17% and 19% stemming from the US JGOFS and LTER programs, respectively. The MAREDAT pigment database provides high quality measurements of the major taxonomic pigments including chlorophylls a and b, 19\u27-butanoyloxyfucoxanthin, 19\u27-hexanoyloxyfucoxanthin, alloxanthin, divinyl chlorophyll a, fucoxanthin, lutein, peridinin, prasinoxanthin, violaxanthin and zeaxanthin, which may be used in varying combinations to estimate phytoplankton community composition. Quality control measures consisted of flagging samples that had a total chlorophyll a concentration of zero, had fewer than four reported accessory pigments, or exceeded two standard deviations of the log-linear regression of total chlorophyll a with total accessory pigment concentrations. We anticipate the MAREDAT pigment database to be of use in the marine ecology, remote sensing and ecological modeling communities, where it will support model validation and advance our global perspective on marine biodiversity. The original dataset together with quality control flags as well as the gridded MAREDAT pigment data may be downloaded from PANGAEA: http://doi.pangaea.de/10.1594/PANGAEA.793246

Effect of folic acid supplementation in pregnancy on preeclampsia: The folic acid clinical trial study

Copyright © 2013 Shi Wu Wen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Preeclampsia (PE) is hypertension with proteinuria that develops during pregnancy and affects at least 5% of pregnancies. The Effect of Folic Acid Supplementation in Pregnancy on Preeclampsia: the Folic Acid Clinical Trial (FACT) aims to recruit 3,656 high risk women to evaluate a new prevention strategy for PE: supplementation of folic acid throughout pregnancy. Pregnant women with increased risk of developing PE presenting to a trial participating center between 80/7 and 166/7 weeks of gestation are randomized in a 1: 1 ratio to folic acid 4.0 mg or placebo after written consent is obtained. Intent-to-treat population will be analyzed. The FACT study was funded by the Canadian Institutes of Health Research in 2009, and regulatory approval from Health Canada was obtained in 2010. A web-based randomization system and electronic data collection system provide the platform for participating centers to randomize their eligible participants and enter data in real time. To date we have twenty participating Canadian centers, of which eighteen are actively recruiting, and seven participating Australian centers, of which two are actively recruiting. Recruitment in Argentina, UK, Netherlands, Brazil, West Indies, and United States is expected to begin by the second or third quarter of 2013. This trial is registered with NCT01355159. © 2013 Shi Wu Wen et al.The Canadian Institutes of Healt