2,724 research outputs found
Cadaveric Renal Transplantation in Diabetics in the 1980's: with Special Reference to Cyclosporine.
Study of advanced fuel system concepts for commercial aircraft and engines
The impact on a commercial transport aircraft of using fuels which have relaxed property limits relative to current commercial jet fuel was assessed. The methodology of the study is outlined, fuel properties are discussed, and the effect of the relaxation of fuel properties analyzed. Advanced fuel system component designs that permit the satisfactory use of fuel with the candidate relaxed properties in the subject aircraft are described. The two fuel properties considered in detail are freezing point and thermal stability. Three candidate fuel system concepts were selected and evaluated in terms of performance, cost, weight, safety, and maintainability. A fuel system that incorporates insulation and electrical heating elements on fuel tank lower surfaces was found to be most cost effective for the long term
Sand in the wheels, or oiling the wheels, of international finance? : New Labour's appeal to a 'new Bretton Woods'
Tony Blairβs political instinct typically is to associate himself only with the future. As such, his explicit appeal to βthe pastβ in his references to New Labourβs desire to establish a βnew Bretton Woodsβ is sufficient in itself to arouse some degree of analytical curiosity (see Blair 1998a). The fact that this appeal was made specifically in relation to Bretton Woods is even more interesting. The resonant image of the international economic context established by the original Bretton Woods agreements invokes a style and content of policy-making which Tony Blair typically dismisses as neither economically nor politically consistent with his preferred vision of the future (see Blair 2000c, 2001b)
Novel Stromal Biomarkers in Human Breast Cancer Tissues Provide Evidence for the More Malignant Phenotype of Estrogen Receptor-Negative Tumors
Research efforts were focused on genetic alterations in epithelial cancer cells. Epithelial-stromal interactions play a crucial role in cancer initiation, progression, invasion, angiogenesis, and metastasis; however, the active role of stroma in human breast tumorigenesis in relation to estrogen receptor (ER) status of epithelial cells has not been explored. Using proteomics and biochemical approaches, we identified two stromal proteins in ER-positive and ER-negative human breast cancer tissues that may affect malignant transformation in breast cancer. Two putative biomarkers, T-cell receptor alpha (TCR-Ξ±) and zinc finger and BRCA1-interacting protein with a KRAB domain (ZBRK1), were detected in leukocytes of ER-positive and endothelial cells of ER-negative tissues, respectively. Our data suggest an immunosuppressive role of leukocytes in invasive breast tumors, propose a multifunctional nature of ZBRK1 in estrogen receptor regulation and angiogenesis, and demonstrate the aggressiveness of ER-negative human breast carcinomas. This research project may identify new stromal drug targets for the treatment of breast cancer patients
Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective
This Report has a number of inter-related general purposes. One is to explore the extent to which food, nutrition, physical activity, and body composition modify the risk of cancer, and to specify which factors are most important. To the extent that environmental factors such as food, nutrition, and physical activity influence the risk of cancer, it is a preventable disease. The Report specifies recommendations based on solid evidence which, when followed, will be expected to reduce the incidence of cancer
Quantum Transition between an Antiferromagnetic Mott Insulator and Superconductor in Two Dimensions
We consider a Hubbard model on a square lattice with an additional
interaction, , which depends upon the square of a near-neighbor hopping. At
half-filling and a constant value of the Hubbard repulsion, increasing the
strength of the interaction drives the system from an antiferromagnetic
Mott insulator to a superconductor. This conclusion is reached
on the basis of zero temperature quantum Monte Carlo simulations on lattice
sizes up to .Comment: 4 pages (latex) and 4 postscript figure
Local Electronic Structure of a Single Magnetic Impurity in a Superconductor
The electronic structure near a single classical magnetic impurity in a
superconductor is determined using a fully self-consistent Koster-Slater
algorithm. Localized excited states are found within the energy gap which are
half electron and half hole. Within a jellium model we find the new result that
the spatial structure of the positive-frequency (electron-like) spectral weight
(or local density of states), can differ strongly from that of the negative
frequency (hole-like) spectral weight. The effect of the impurity on the
continuum states above the energy gap is calculated with good spectral
resolution for the first time. This is also the first three-dimensional
self-consistent calculation for a strong magnetic impurity potential.Comment: 13 pages, RevTex, change in heuristic picture, no change in numerical
result
Josephson current through a Luttinger liquid
We study the Josephson effect through a one-dimensional system of interacting
electrons, connected to two superconductors by tunnel junctions. The
interactions are treated in the framework of the one-channel Luttinger model.
At zero temperature, the Josephson critical current is found to decay
algebraically with increasing distance between the junctions. The exponent is
proportional to the strength of the Coulomb interaction. If the Luttinger
liquid has a finite size, the Josephson current depends on the total number of
electrons modulo 4. These parity effects are studied for the ring, coupled
capacitively to a gate-voltage and threaded by a magnetic flux. The Josephson
current changes continuously as a function of the gate voltage and {\em
stepwise} as a function of the magnetic flux. The electron-electron interaction
introduces {\em qualitatively} new features compared to the non-interacting
case.Comment: 8 pages REVTEX , 4 figures available upon reques
Evidence for a superfluid density in t--J ladders
Applying three independent techniques, we give numerical evidence for a
finite superfluid density in isotropic hole-doped t--J ladders: We show the
existence of anomalous flux quantization, emphasising the contrasting behaviour
to that found in the `Luttinger liquid' regime stabilised at low electron
densities; We consider the nature of the low-lying excitation modes, finding
the 1-D analog of the superconducting state; And using a density matrix
renormalization group approach, we find long range pairing correlations and
exponentially decaying spin-spin correlations.Comment: 4 pages, revtex, postscript figs included, submitted to PR
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