Certain minimal varieties are set-theoretic complete intersections

We present a class of homogeneous ideals which are generated by monomials and binomials of degree two and are set-theoretic complete intersections. This class includes certain reducible varieties of minimal degree and, in particular, the presentation ideals of the fiber cone algebras of monomial varieties of codimension two

Cosmic Swarms: A search for Supermassive Black Holes in the LISA data stream with a Hybrid Evolutionary Algorithm

We describe a hybrid evolutionary algorithm that can simultaneously search for multiple supermassive black hole binary (SMBHB) inspirals in LISA data. The algorithm mixes evolutionary computation, Metropolis-Hastings methods and Nested Sampling. The inspiral of SMBHBs presents an interesting problem for gravitational wave data analysis since, due to the LISA response function, the sources have a bi-modal sky solution. We show here that it is possible not only to detect multiple SMBHBs in the data stream, but also to investigate simultaneously all the various modes of the global solution. In all cases, the algorithm returns parameter determinations within $5\sigma$ (as estimated from the Fisher Matrix) of the true answer, for both the actual and antipodal sky solutions.Comment: submitted to Classical & Quantum Gravity. 19 pages, 4 figure

A Reciprocal Cell–Cell Interaction Mediated by NT-3 and Neuregulins Controls the Early Survival and Development of Sympathetic Neuroblasts

Neurotrophin 3 (NT-3) can support the survival of some embryonic sympathetic neuroblasts before they become nerve growth factor dependent. We show that NT-3 is produced in vivo by nonneuronal cells neighboring embryonic sympathetic ganglia. NT-3 mRNA is produced by these nonneuronal cells in vitro and is up-regulated by platelet-derived growth factor, ciliary neurotrophic factor, and glial growth factor 2 (a neuregulin). Nonneuronal cell–conditioned medium promotes survival and induces TrkA expression in isolated sympathetic neuroblasts, and this activity is blocked by anti-NT-3 antibody. Neuroblasts also enhance NT-3 production by nonneuronal cells. Neuroblasts synthesize several forms of neuregulin, and antibodies to neuregulin attenuate the effect of the neuroblasts on the nonneuronal cells. These data suggest a reciprocal cell–cell interaction, in which neuroblast-derived neuregulins promote NT-3 production by neighboring nonneuronal cells, which in turn promotes neuroblast survival and further differentiation

STIM Proteins and Orai Ca2+ Channels Are Involved in the Intracellular Pathways Activated by TLQP-21 in RAW264.7 Macrophages

TLQP-21 is a neuropeptide which has been implicated in regulation of nociception and other relevant physiologic functions. Although recent studies identified C3a and gC1q receptors as targets for TLQP-21, its intracellular molecular mechanisms of action remain largely unidentified. Our aim was (i) to explore the intracellular signaling pathway(s) activated by JMV5656, a novel derivative of TLQP-21, in RAW264.7 macrophages, and (ii) to assess linkages of these pathways with its purported receptors. JMV5656 stimulated, in a dose-dependent fashion, a rapid and transient increase in intracellular Ca2+ concentrations in RAW264.7 cells; repeated exposure to the peptide resulted in a lower response, suggesting a possible desensitization mechanism of the receptor. In particular, JMV5656 increased cytoplasmic Ca2+ levels by a PLC-dependent release of Ca2+ from the endoplasmic reticulum. STIM proteins and Orai Ca2+ channels were activated and played a crucial role. In fact, treatment of the cells with U73122 and thapsigargin modulated the increase of intracellular Ca2+ levels stimulated by JMV5656. Moreover, in RAW264.7 cells intracellular Ca2+ increases did not occur through the binding of JMV5656 to the C3a receptor, since the increase of intracellular Ca2+ levels induced by JMV5656 was not affected by specific siRNA against C3aR. In summary, our study provides new indications for the downstream effects of JMV5656 in macrophages, suggesting that it could activate receptors different from the C3aR

Implementing the Five-A Model of technical refinement: Key roles of the sport psychologist

There is increasing evidence for the significant contribution provided by sport psychologists within applied coaching environments. However, this rarely considers their skills/knowledge being applied when refining athletes’ already learned and well-established motor skills. Therefore, this paper focuses on how a sport psychologist might assist a coach and athlete to implement long-term permanent and pressure proof refinements. It highlights key contributions at each stage of the Five-A Model—designed to deliver these important outcomes—providing both psychomotor and psychosocial input to the support delivery. By employing these recommendations, sport psychologists can make multiple positive contributions to completion of this challenging task

Inducible Germline IgMs Bridge Trypanosome Lytic Factor Assembly and Parasite Recognition

Acknowledgments This work was supported by NSF Bread award IOS-1249166 and Hunter College (J.R.); CUNY Science Scholarship (J.V.); Hunter College HHMI UGRAD Science Education grant 52007535 (E.H.); NIH/NIAID award AI085973 (N.P.); Wellcome Trust award 082786 (J.S.). We thank George Cross and Ana Rodriguez for the parasite lines and VSG preparations used in this study.Peer reviewedPostprin