People with cerebral palsy and their family’s preferences about genomics research

Introduction: The goal of this study was to understand individuals with cerebral palsy (CP) and their family’s attitudes and preferences to genomic research, including international data sharing and biobanking. Methods: Individuals with CP and their family members were invited to participate in the web-based survey via email (NSW/ACT CP Register) or via posts on social media by Cerebral Palsy Alliance, CP Research Network, and CP Now. Survey responses included yes/no/unsure, multiple choices, and Likert scales. Fisher’s exact and χ2 tests were used to assess if there were significant differences between subgroups. Results: Individuals with CP and their families (n = 145) were willing to participate in genomics research (68%), data sharing (82%), and biobanking efforts (75%). This willingness to participate was associated with completion of tertiary education, previous genetic testing experience, overall higher genomic awareness, and trust in international researchers. The survey respondents also expressed ongoing communication and diverse information needs regarding the use of their samples and data. Major concerns were associated with privacy and data security. Discussion: The success of genomic research and international data sharing efforts in CP are contingent upon broad support and recruitment. Ongoing consultation and engagement of individuals with CP and their families will facilitate trust and promote increased awareness of genomics in CP that may in turn maximize participant uptake and recruitment

Effects of Feed Truck RPM on Pellet Quality, Unloading Speed, and Feed Line Location on Pellet Quality and Nutrient Segregation

Two separate studies were conducted at one commercial feed mill and six commercial wean-to-finish pig sites in northwest Iowa to determine the effects of feed truck unloading auger RPM on pellet quality and unloading time (Exp. 1) and the effects of feed line location on pellet quality and nutrient concentration of intact pellets and their fines (Exp. 2). For Exp. 1, feed samples were taken from each compartment of an 8-compartment, 24-ton Walinga (Walinga Inc., Guelph, Ontario) feed truck. Feed was unloaded using 3 unloading speeds as determined by the truck RPM of 900, 1,150, and 1,400. Each compartment was timed during unloading, and percentage fines and PDI were determined from each sample taken. The same truck was used 6 times, allowing for 16 replications per unloading speed and 6 replications per compartment. The compartment located closest to the truck cab was denoted as compartment 1, and the compartment located closest to the rear of the truck was denoted as compartment 8. An unloading speed × trailer compartment interaction (P = 0.031) was observed. The difference in unloading time for each compartment became progressively less, the closer the compartment was to the back of the truck. The percentage of fines formed was not significantly different among unloading speeds. The percentage of fines formed during unloading tended to increase (quadratic; P = 0.081) from the first to the eighth compartment, with the maximum percentage of fines formed occurring in the fifth compartment. In Exp. 2, pelleted feed was sampled as feed was unloaded into a commercial feed bin at 6 wean-to-finish barn sites. Each barn was equipped with 2 separate feed lines that transported feed from the bin into the barn. Feed samples were taken inside the barn at the feeder closest to the bin (20 ft), halfway from the bin (115 ft), and the farthest from the bin (250 ft) for each feed line. Samples were analyzed for percentage fines and PDI. During analysis, fines and complete pellets were separated, and a nutrient profile was determined for each. No interactions were observed between feed line location and nutrient profile of the fines and pellets. There was no effect of feed line location on pellet PDI, percentage fines, percentage fines formed, or pellet and fines nutrient profile. Fines had decreased (P \u3c 0.05) CP and P but increased (P \u3c 0.05) ADF, crude fiber, Ca, ether extract, and starch were observed when compared to the composition of pellets. In conclusion, feed flow from the compartments closer to the cab resulted in fewer fines formed from loading to unloading. Decreasing unloading speed significantly increased the amount of time taken to unload a feed truck. No differences were observed in the amount of fines formed for any of the unloading speeds. There appear to be no differences in pellet quality among feed line locations within a commercial wean to finish barn; however, there are significant differences in nutrient profile between fines and pellets

Laser clad and HVOF sprayed Stellite 6 coating in chlorine rich environment with KCI at 700 °C

Laser clads and HVOF coatings from a stellite 6 alloy (Co–Cr–W–C alloy) on 304 stainless steel substrates were exposed both bare and with KCl deposits in 500 ppm HCl with 5% O2 for 250 h at 700 C. SEM/EDX and PXRD analyses with Rietveld refinement were used for assessment of the attack and for analysis of the scales. The bare samples suffered from scale spallation and the scale was mostly composed of Cr2O3, CoCr2O4 and CoO, although due to dilution haematite (Fe2O3) was detected in the scale formed on the laser clad sample. A small amount of hydrated HCl was detected in bare samples. While the corrosion of the bare surfaces was limited to comparatively shallow depths and manifested by g and M7C3 carbide formation, the presence of KCl on the surface led to severe Cr depletion from the HVOF coating (to 1 wt%). Both inward and outward diffusion of elements occurred in the HVOF coating resulting in Kirdendall voids at the coating–steel interface. The laser clad sample performed significantly better in conditions of the KCl deposit-induced corrosion. In addition to the oxides, CoCl2 was detected in the HVOF sample and K3CrO4 was detected in the laser clad sample. Thermodynamic calculations and kinetic simulations were carried out to interpret the oxidation and diffusion behaviours of coatings

Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial

© 2017 Elsevier Ltd Background Reoperation rates are high after surgery for hip fractures. We investigated the effect of a sliding hip screw versus cancellous screws on the risk of reoperation and other key outcomes. Methods For this international, multicentre, allocation concealed randomised controlled trial, we enrolled patients aged 50 years or older with a low-energy hip fracture requiring fracture fixation from 81 clinical centres in eight countries. Patients were assigned by minimisation with a centralised computer system to receive a single large-diameter screw with a side-plate (sliding hip screw) or the present standard of care, multiple small-diameter cancellous screws. Surgeons and patients were not blinded but the data analyst, while doing the analyses, remained blinded to treatment groups. The primary outcome was hip reoperation within 24 months after initial surgery to promote fracture healing, relieve pain, treat infection, or improve function. Analyses followed the intention-to-treat principle. This study was registered with ClinicalTrials.gov, number NCT00761813. Findings Between March 3, 2008, and March 31, 2014, we randomly assigned 1108 patients to receive a sliding hip screw (n=557) or cancellous screws (n=551). Reoperations within 24 months did not differ by type of surgical fixation in those included in the primary analysis: 107 (20%) of 542 patients in the sliding hip screw group versus 117 (22%) of 537 patients in the cancellous screws group (hazard ratio [HR] 0·83, 95% CI 0·63–1·09; p=0·18). Avascular necrosis was more common in the sliding hip screw group than in the cancellous screws group (50 patients [9%] vs 28 patients [5%]; HR 1·91, 1·06–3·44; p=0·0319). However, no significant difference was found between the number of medically related adverse events between groups (p=0·82; appendix); these events included pulmonary embolism (two patients [\u3c1%] vs four [1%] patients; p=0·41) and sepsis (seven [1%] vs six [1%]; p=0·79). Interpretation In terms of reoperation rates the sliding hip screw shows no advantage, but some groups of patients (smokers and those with displaced or base of neck fractures) might do better with a sliding hip screw than with cancellous screws. Funding National Institutes of Health, Canadian Institutes of Health Research, Stichting NutsOhra, Netherlands Organisation for Health Research and Development, Physicians\u27 Services Incorporated

The organic food philosophy. A qualitative exploration of the practices, values, and beliefs of Dutch organic consumers within a cultural-historical frame

Food consumption has been identified as a realm of key importance for progressing the world towards more sustainable consumption overall. Consumers have the option to choose organic food as a visible product of more ecologically integrated farming methods and, in general, more carefully produced food. This study aims to investigate the choice for organic from a cultural-historical perspective and aims to reveal the food philosophy of current organic consumers in The Netherlands. A concise history of the organic food movement is provided going back to the German Lebensreform and the American Natural Foods Movement. We discuss themes such as the wish to return to a more natural lifestyle, distancing from materialistic lifestyles, and reverting to a more meaningful moral life. Based on a number of in-depth interviews, the study illustrates that these themes are still of influence among current organic consumers who additionally raised the importance of connectedness to nature, awareness, and purity. We argue that their values are shared by a much larger part of Dutch society than those currently shopping for organic food. Strengthening these cultural values in the context of more sustainable food choices may help to expand the amount of organic consumers and hereby aid a transition towards more sustainable consumption. © 2012 The Author(s)