Toy Models for Galaxy Formation versus Simulations

We describe simple useful toy models for key processes of galaxy formation in its most active phase, at z > 1, and test the approximate expressions against the typical behaviour in a suite of high-resolution hydro-cosmological simulations of massive galaxies at z = 4-1. We address in particular the evolution of (a) the total mass inflow rate from the cosmic web into galactic haloes based on the EPS approximation, (b) the penetration of baryonic streams into the inner galaxy, (c) the disc size, (d) the implied steady-state gas content and star-formation rate (SFR) in the galaxy subject to mass conservation and a universal star-formation law, (e) the inflow rate within the disc to a central bulge and black hole as derived using energy conservation and self-regulated Q ~ 1 violent disc instability (VDI), and (f) the implied steady state in the disc and bulge. The toy models provide useful approximations for the behaviour of the simulated galaxies. We find that (a) the inflow rate is proportional to mass and to (1+z)^5/2, (b) the penetration to the inner halo is ~50% at z = 4-2, (c) the disc radius is ~5% of the virial radius, (d) the galaxies reach a steady state with the SFR following the accretion rate into the galaxy, (e) there is an intense gas inflow through the disc, comparable to the SFR, following the predictions of VDI, and (f) the galaxies approach a steady state with the bulge mass comparable to the disc mass, where the draining of gas by SFR, outflows and disc inflows is replenished by fresh accretion. Given the agreement with simulations, these toy models are useful for understanding the complex phenomena in simple terms and for back-of-the-envelope predictions.Comment: Resubmitted to MNRAS after responding to referee's comments; Revised figure

What are effective medication combinations for dyslipidemia?

Many combination drug therapies are effective in treating dyslipidemia. Compared with statin monotherapy, combinations that include ezetimibe (Zetia), a bile acid sequestrant, or niacin further lower low- density lipoprotein (LDL) cholesterol (strength of recommendation [SOR]: A), and increase the likelihood of attaining National Cholesterol Education Program (NCEP) LDL cholesterol goals (SOR: B). Adding ezetimibe to a bile acid sequestrant reduces LDL cholesterol (SOR: B). Fibrate or niacin added to statin monotherapy provide mixed lipid-modifying effects for combined dyslipidemia (SOR: A)

Five-minute Apgar score and educational outcomes: retrospective cohort study of 751 369 children

Background: The Apgar score is used worldwide for assessing the clinical condition and short-term prognosis of newborn infants. Evidence for a relationship with long-term educational outcomes is conflicting. We investigated whether Apgar score at 5 min after birth was associated with additional support needs (ASN) and educational attainment. Methods: Data on pregnancy, delivery and later educational outcomes for children attending Scottish schools between 2006 and 2011 were collated by linking individual-level data from national educational and maternity databases. The relationship between Apgar score and overall ASN, type-specific ASN and educational attainment was assessed using binary, multinomial and generalised ordinal logistic regression models, respectively. Missing covariate data were imputed. Results: Of the 751 369 children eligible, 9741 (1.3%) had a low or intermediate Apgar score and 49 962 (6.6%) had ASN. Low Apgar score was independently associated with overall ASN status (adjusted OR for Apgar ≤3, OR 1.52 95% CI 1.35 to 1.70), as well as ASN due to cognitive (OR 1.26, 95% CI 1.09 to 1.47), sensory (OR 2.49 95% CI 1.66 to 3.73) and motor (OR 3.57, 95% CI 2.86 to 4.47) impairments. There was a dose-response relationship between Apgar score and overall ASN status: of those scoring 0–3, 10.1% had ASN, compared with 9.1% of those scoring 4–7 and 6.6% of those scoring 7–10. A low Apgar score was associated with lower educational attainment, but this was not robust to adjustment for confounders. Conclusions: Apgar scores are associated with long-term as well as short-term prognoses, and with educational as well as clinical outcomes at the population level

Mapping the real space distributions of galaxies in SDSS DR7: I. Two Point Correlation Functions

Using a method to correct redshift space distortion (RSD) for individual galaxies, we mapped the real space distributions of galaxies in the Sloan Digital Sky Survey (SDSS) Data Release 7 (DR7). We use an ensemble of mock catalogs to demonstrate the reliability of our method. Here as the first paper in a series, we mainly focus on the two point correlation function (2PCF) of galaxies. Overall the 2PCF measured in the reconstructed real space for galaxies brighter than $^{0.1}{\rm M}_r-5\log h=-19.0$ agrees with the direct measurement to an accuracy better than the measurement error due to cosmic variance, if the reconstruction uses the correct cosmology. Applying the method to the SDSS DR7, we construct a real space version of the main galaxy catalog, which contains 396,068 galaxies in the North Galactic Cap with redshifts in the range $0.01 \leq z \leq 0.12$. The Sloan Great Wall, the largest known structure in the nearby Universe, is not as dominant an over-dense structure as appears to be in redshift space. We measure the 2PCFs in reconstructed real space for galaxies of different luminosities and colors. All of them show clear deviations from single power-law forms, and reveal clear transitions from 1-halo to 2-halo terms. A comparison with the corresponding 2PCFs in redshift space nicely demonstrates how RSDs boost the clustering power on large scales (by about $40-50\%$ at scales $\sim 10 h^{-1}{\rm {Mpc}}$) and suppress it on small scales (by about $70-80\%$ at a scale of $0.3 h^{-1}{\rm {Mpc}}$).Comment: 19 pages, 13 figure

Recent Developments in Three Dimensional Radiation Transport Using the Green's Function Technique

In the future, astronauts will be sent into space for longer durations of time compared to previous missions. The increased risk of exposure to dangerous radiation, such as Galactic Cosmic Rays and Solar Particle Events, is of great concern. Consequently, steps must be taken to ensure astronaut safety by providing adequate shielding. In order to better determine and verify shielding requirements, an accurate and efficient radiation transport code based on a fully three dimensional radiation transport model using the Green's function technique is being develope

Mapping the Real Space Distributions of Galaxies in SDSS DR7: II. Measuring the growth rate, clustering amplitude of matter and biases of galaxies at redshift 0.10.1

We extend the real-space mapping method developed in Shi et at. (2016) so that it can be applied to flux-limited galaxy samples. We use an ensemble of mock catalogs to demonstrate the reliability of this extension, showing that it allows for an accurate recovery of the real-space correlation functions and galaxy biases. We also demonstrate that, using an iterative method applied to intermediate-scale clustering data, we can obtain an unbiased estimate of the growth rate of structure $f\sigma_8$, which is related to the clustering amplitude of matter, to an accuracy of $\sim 10\%$. Applying this method to the Sloan Digital Sky Survey (SDSS) Data Release 7 (DR7), we construct a real-space galaxy catalog spanning the redshift range $0.01 \leq z \leq 0.2$, which contains 584,473 galaxies in the north Galactic cap (NGC). Using this data, we infer \fss at a median redshift $z=0.1$, which is consistent with the WMAP9 cosmology at the $1\sigma$ level. By combining this measurement with the real-space clustering of galaxies and with galaxy-galaxy weak lensing measurements for the same sets of galaxies, we are able to break the degeneracy between $f$, $\sigma_8$, and $b$. From the SDSS DR7 data alone, we obtain the following cosmological constraints at redshift $z=0.1$: $f=$$0.464^{+0.040}_{-0.040}$, $\sigma_8=0.769^{+0.121}_{-0.089}$, and $b=1.910^{+0.234}_{-0.268}$, $1.449^{+0.194}_{-0.196}$, $1.301^{+0.170}_{-0.177}$, and $1.196^{+0.159}_{-0.161}~$ for galaxies within different absolute magnitude bins $^{0.1}{\rm M}_r-5\log h=[-23,0, -22.0], [-22,0, -21.0], [-21.0, -20.0]$ and $[-20.0, -19.0]$, respectively

Increased risk of HIV and other drug-related harms associated with injecting in public places: national bio-behavioural survey of people who inject drugs

Background: Whilst injecting drugs in public places is considered a proxy for high risk behaviour among people who inject drugs (PWID), studies quantifying its relationship with multiple drug-related harms are lacking and none have examined this in the context of an ongoing HIV outbreak (located in Glasgow, Scotland). We aimed to: 1) estimate the prevalence of public injecting in Scotland and associated risk factors; and 2) estimate the association between public injecting and HIV, current HCV, overdose, and skin and soft tissue infections (SSTI). Methods: Cross-sectional, bio-behavioural survey (including dried blood spot testing to determine HIV and HCV infection) of 1469 current PWID (injected in last 6 months) recruited by independent interviewers from 139 harm reduction services across Scotland during 2017–18. Primary outcomes were: injecting in a public place (yes/no); HIV infection; current HCV infection; self-reported overdose in the last year (yes/no) and SSTI the last year (yes/no). Multi-variable logistic regression was used to determine factors associated with public injecting and to estimate the association between public injecting and drug-related harms (HIV, current HCV, overdose and SSTI). Results: Prevalence of public injecting was 16% overall in Scotland and 47% in Glasgow city centre. Factors associated with increased odds of public injecting were: recruitment in Glasgow city centre (aOR=5.45, 95% CI 3.48–8.54, p<0.001), homelessness (aOR=3.68, 95% CI 2.61–5.19, p<0.001), high alcohol consumption (aOR=2.42, 95% CI 1.69–3.44, p<0.001), high injection frequency (≥4 per day) (aOR=3.16, 95% CI 1.93–5.18, p<0.001) and cocaine injecting (aOR=1.46, 95% CI 1.00 to 2.13, p = 0.046). Odds were lower for those receiving opiate substitution therapy (OST) (aOR=0.37, 95% CI 0.24 to 0.56, p<0.001) and older age (per year increase) (aOR=0.97, 95% CI 0.95 to 0.99, p = 0.013). Public injecting was associated with an increased risk of HIV infection (aOR=2.11, 95% CI 1.13–3.92, p = 0.019), current HCV infection (aOR=1.49, 95% CI 1.01–2.19, p = 0.043), overdose (aOR=1.59, 95% CI 1.27–2.01, p<0.001) and SSTI (aOR=1.42, 95% CI 1.17–1.73, p<0.001). Conclusions: These findings highlight the need to address the additional harms observed among people who inject in public places and provide evidence to inform proposals in the UK and elsewhere to introduce facilities that offer safer drug consumption environments