Serous tubal intraepithelial carcinomas associated with high-grade serous ovarian carcinomas: a systematic review.

Background Serous tubal intraepithelial carcinomas (STICs) have been documented in high-grade serous ovarian carcinomas (HGSOCs). However, the rate of association between STICs and HGSOCs and, therefore, the fraction of HGSOCs that are likely to have originated from the fallopian tube (FT), has remained unclear. Objective To appraise the literature describing the association between STICs and established HGSOCs. Search strategy Ovid MEDLINE and EMBASE were searched. Selection criteria Studies were included if they evaluated the frequency of STICs in HGSOCs, and were published in an English peer-reviewed journal. Data collection and analysis Appropriate studies were evaluated for their compliance with the ‘Strengthening and Reporting of Observational Studies in Epidemiology (STROBE)’ criteria. Main results Ten articles met the study selection criteria. The reported coexistence between STICs and HGSOCs ranged from 11% to 61% (mean: 31%, 95% CI: 17–46%). STICs were rarely found in other gynaecological cancers. Small sample size, lack of objective criteria to identify STICs and the retrospective nature of the studies contributed to the variability in reporting the rate of the association. Conclusions STICs were identified commonly in the FTs of women with HGSOC. Finding the true rate of association between STICs and HGSOCs will require further investigations. While there is evidence that a fraction of HGSOCs arise from the FTs, an accurate estimate of that fraction remains to be determined. The lack of an accurate estimate of the association makes it difficult to evaluate the potential magnitude of reduction of HGSOCs following prophylactic salpingectomy.</p

Serous tubal intraepithelial carcinomas associated with high-grade serous ovarian carcinomas: a systematic review.

Background Serous tubal intraepithelial carcinomas (STICs) have been documented in high-grade serous ovarian carcinomas (HGSOCs). However, the rate of association between STICs and HGSOCs and, therefore, the fraction of HGSOCs that are likely to have originated from the fallopian tube (FT), has remained unclear. Objective To appraise the literature describing the association between STICs and established HGSOCs. Search strategy Ovid MEDLINE and EMBASE were searched. Selection criteria Studies were included if they evaluated the frequency of STICs in HGSOCs, and were published in an English peer-reviewed journal. Data collection and analysis Appropriate studies were evaluated for their compliance with the ‘Strengthening and Reporting of Observational Studies in Epidemiology (STROBE)’ criteria. Main results Ten articles met the study selection criteria. The reported coexistence between STICs and HGSOCs ranged from 11% to 61% (mean: 31%, 95% CI: 17–46%). STICs were rarely found in other gynaecological cancers. Small sample size, lack of objective criteria to identify STICs and the retrospective nature of the studies contributed to the variability in reporting the rate of the association. Conclusions STICs were identified commonly in the FTs of women with HGSOC. Finding the true rate of association between STICs and HGSOCs will require further investigations. While there is evidence that a fraction of HGSOCs arise from the FTs, an accurate estimate of that fraction remains to be determined. The lack of an accurate estimate of the association makes it difficult to evaluate the potential magnitude of reduction of HGSOCs following prophylactic salpingectomy.</p

ASKFOOD, a knowledge alliance between businesses and academia in the food-related sectors to leverage innovation and sustainability

ASKFOOD, a knowledge alliance between businesses and academia in the food-related sectors to leverage innovation and sustainability/Pittia, P.; Di Falco, G.; Schleining, G.; Tsaltas, D.; Drausinger, J.; Verker, R.; Biesdorf, B.; Medic, H.; Lazaro-Mojica, J.; Sabbatini, G.; Salta, F..-ELETTRONICO.-(2020).((Intervento presentato al convegno 34th EFFoST International Conference Bridging high-tech, food-tech and health: Consumer-oriented innovations

Reliability of visual diagnosis of endometriosis

ObjectiveTo determine whether accuracy of visual diagnosis of endometriosis at laparoscopy is determined by stage of disease.DesignProspective longitudinal cohort study (Canadian Task Force classification II-2).SettingTertiary referral centers in three Australian states.PatientsOf 1439 biopsy specimens, endometriosis was proved in at least one specimen in 431 patients.InterventionsLaparoscopy with visual diagnosis and staging of endometriosis followed by histopathologic analysis and confirmation. Operations were performed by five experienced laparoscopic gynecologists.Measurements and main resultsHistopathologic confirmation of visual diagnosis of endometriosis adjusted for significant covariates. Endometriosis was accurately diagnosed in 49.7% of American Society for Reproductive Medicine (ASRM) stage I, which was significantly less accurate than for other stages of endometriosis. Deep endometriosis was more likely to be diagnosed accurately than superficial endometriosis (adjusted odds ratio, 2.51; 95% confidence interval, 1.50-4.18; p ConclusionThe accuracy of visual diagnosis of endometriosis was substantially influenced by American Society of Reproductive Medicine stage, the depth and volume of the lesion, and to a lesser extent the location of the lesion.Shavi Fernando, Pei Qian Soh, Michael Cooper, Susan Evans, Geoffrey Reid, Jim Tsaltas, Luk Rombaut

Disruption and Overexpression of the Gene Encoding ACC (1-Aminocyclopropane-1-Carboxylic Acid) Deaminase in Soil-Borne Fungal Pathogen Verticillium dahliae Revealed the Role of ACC as a Potential Regulator of Virulence and Plant Defense

It has been suggested that some microorganisms, including plant growth-promoting rhizobacteria, manipulate the level of ethylene in plants by degrading 1-aminocyclopropane-1-carboxylic acid (ACC), an ethylene precursor, into α-ketobutyrate and ammonia, using ACC deaminase (ACCd). Here, we investigated whether ACCd of Verticillium dahliae, a soil-borne fungal pathogen of many important crops, is involved in causing vascular wilt disease. Overexpression of the V. dahliae gene encoding this enzyme, labeled as ACCd, significantly increased virulence in both tomato and eggplant, while disruption of ACCd reduced virulence. Both types of mutant produced more ethylene than a wild-type (70V-WT) strain, although they significantly differed in ACC content. Overexpression strains lowered ACC levels in the roots of infected plants, while the amount of ACC in the roots of plants infected with deletion mutants increased. To test the hypothesis that ACC acts as a signal for controlling defense, roots of WT and Never-ripe (Nr) tomato plants were treated with ACC before V. dahliae inoculation. Plants pretreated with ACC displayed less severe symptoms than untreated controls. Collectively, our results suggest a novel role of ACC as a regulator of both plant defense and pathogen virulence