CLUPI, a high-performance Imaging System on the rover of theExoMars Mission 2020 to doscover biofabrics on MARS. Science objectives and development status

The scientific objectives of the 2020 ExoMars rover mission are to search for traces of past or present life and to characterise the near-sub surface. Both objectives require study of the rock/regolith materials in terms of structure, textures, mineralogy, and elemental and organic composition. The 2020 ExoMars rover payload consists of a suite of complementary instruments designed to reach These objectives. CLUPI, the high-performance colour close up imager, on board the 2020 ExoMars Rover plays an important role in attaining the mission objectives: it is the equivalent of the hand lens that no geologist is without when undertaking field work. CLUPI is a powerful, highly integrated miniaturized (<900g) low-power robust imaging system, able to sustain very low temperatures (–120°C). CLUPI has a working distance from 11.5cm to infinite providing outstanding pictures with a color detector of 2652x1768x3. At 11.5cm, the spatial resolution is 8 micrometer/pixel in color. The optical-mechanical interface is a smart assembly that can sustain a wide temperature range. The concept benefits from wellproven heritage: Proba, Rosetta, MarsExpress and Smart-1 missions

The Close-Up Imager Onboard the ESA ExoMars Rover: Objectives, Description, Operations and Science Validation Activities

The Close-Up Imager (CLUPI) onboard the ESA ExoMars Rover is a powerful high-resolution color camera specifically designed for close-up observations. Its accommodation on the movable drill allows multiple po- sitioning. The science objectives of the instrument are geological characterization of rocks in terms of texture, structure, and color and the search for potential morphological biosignatures. We present the CLUPI science objectives, performance, and technical description, followed by a description of the instrument’s planned operations strategy during the mission on Mars. CLUPI will contribute to the rover mission by surveying the geological environment, acquiring close-up images of outcrops, observing the drilling area, inspecting the top portion of the drill borehole (and deposited fines), monitoring drilling operations, and imaging samples col- lected by the drill. A status of the current development and planned science validation activities is also given. Key Words: Mars-Biosignatures-Planetary Instrumentation. Astrobiology 17, 595–611

Spatial multi-omic map of human myocardial infarction

Myocardial infarction is a leading cause of death worldwide1. Although advances have been made in acute treatment, an incomplete understanding of remodelling processes has limited the effectiveness of therapies to reduce late-stage mortality2. Here we generate an integrative high-resolution map of human cardiac remodelling after myocardial infarction using single-cell gene expression, chromatin accessibility and spatial transcriptomic profiling of multiple physiological zones at distinct time points in myocardium from patients with myocardial infarction and controls. Multi-modal data integration enabled us to evaluate cardiac cell-type compositions at increased resolution, yielding insights into changes of the cardiac transcriptome and epigenome through the identification of distinct tissue structures of injury, repair and remodelling. We identified and validated disease-specific cardiac cell states of major cell types and analysed them in their spatial context, evaluating their dependency on other cell types. Our data elucidate the molecular principles of human myocardial tissue organization, recapitulating a gradual cardiomyocyte and myeloid continuum following ischaemic injury. In sum, our study provides an integrative molecular map of human myocardial infarction, represents an essential reference for the field and paves the way for advanced mechanistic and therapeutic studies of cardiac disease