Mass Outflows from Dissipative Shocks in Hot Accretion Flows

We consider stationary, axisymmetric hydrodynamic accretion flows in Kerr geometry. As a plausible means of efficiently separating a small population of nonthermal particles from the bulk accretion flows, we investigate the formation of standing dissipative shocks, i.e. shocks at which fraction of the energy, angular momentum and mass fluxes do not participate in the shock transition of the flow that accretes onto the compact object but are lost into collimated (jets) or uncollimated (winds) outflows. The mass loss fraction (at a shock front) is found to vary over a wide range (0 - 95%) depending on flow's angular momentum and energy. On the other hand, the associated energy loss fraction appears to be relatively low (<1%) for a flow onto a non-rotating black hole case, whereas the fraction could be an order of magnitude higher (<10%) for a flow onto a rapidly-rotating black hole. By estimating the escape velocity of the outflowing particles with a mass-accretion rate relevant for typical active galactic nuclei, we find that nearly 10% of the accreting mass could escape to form an outflow in a disk around a non-rotating black hole, while as much as 50% of the matter may contribute to outflows in a disk around a rapidly-rotating black hole. In the context of disk-jet paradigm, our model suggests that shock-driven outflows from accretion can occur in regions not too far from a central engine. Our results imply that a shock front under some conditions could serve as a plausible site where (nonthermal) seed particles of the outflows (jets/winds) are efficiently decoupled from bulk accretion.Comment: 25 pages, 10 black&white figures, Accepted to Ap

Stability of accretion disk around rotating black holes: a pseudo-general-relativistic fluid dynamical study

We discuss the solution of accretion disk when the black hole is chosen to be rotating. We study, how the fluid properties get affected for different rotation parameters of the black hole. We know that no cosmic object is static in Universe. Here the effect of the rotation of the black hole to the space-time is considered following an earlier work of the author, where the pseudo-Newtonian potential was prescribed for the Kerr geometry. We show that, with the inclusion of rotation of the black hole, the valid disk parameter region dramatically changes and disk becomes unstable. Also we discuss about the possibility of shock in accretion disk around rotating black holes. When the black hole is chosen to be rotating, the sonic locations of the accretion disk get shifted or disappear, making the disk unstable. To bring it in the stable situation, the angular momentum of the accreting matter has to be reduced/enhanced (for co/counter-rotating disk) by means of some physical process.Comment: 24 Latex pages including 7 figures; Accepted for publication in Astrophysical Journa

Isothermal Shock Formation in Non-Equatorial Accretion Flows around Kerr Black Holes

We explore isothermal shock formation in non-equatorial, adiabatic accretion flows onto a rotating black hole, with possible application to some active galactic nuclei (AGNs). The isothermal shock jump conditions as well as the regularity condition, previously developed for one-dimensional (1D) flows in the equatorial plane, are extended to two-dimensional (2D), non-equatorial flows, to explore possible geometrical effects. The basic hydrodynamic equations with these conditions are self-consistently solved in the context of general relativity to explore the formation of stable isothermal shocks. We find that strong shocks are formed in various locations above the equatorial plane, especially around a rapidly-rotating black hole with the prograde flows (rather than a Schwarzschild black hole). The retrograde flows are generally found to develop weaker shocks. The energy dissipation across the shock in the hot non-equatorial flows above the cooler accretion disk may offer an attractive illuminating source for the reprocessed features, such as the iron fluorescence lines, which are often observed in some AGNs.Comment: 22 pages with 11 figures, presented at 5th international conference on high energy density laboratory astrophysics in Tucson, Arizona. accepted to Ap

Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.This study was supported by the Federal Ministry of Education and Research (BMBF, Germany, FKZ 01EO1502). This work was supported, in part, by the William Harvey Research Foundation and forms part of the research themes contributing to the translational research portfolio of Barts and the London Cardiovascular Biomedical Research Unit that is supported and funded by the National Institute of Health Research. This work also contributes to the Organ Protection research theme of the Barts Centre for Trauma Sciences supported by the Barts and The London Charity (Award 753/1722). JP was supported by the German Research Foundation SFB 1039. AH was supported by the Swiss National Science Foundation

Origin and interpretation of kilohertz QPOs from strange stars in X-ray binary system: theoretical hydrodynamical description

We model and interpret the Kilohertz QPOs from the hydrodynamical description of accretion disk around a rapidly rotating compact strange star. The higher QPO frequency is described by the viscous effects of accretion disk leading to shocks, while the lower one is taken to be the Keplerian motion of the accreting matter. Comparing our results with the observations for two of the fastest rotating compact stellar candidates namely, 4U~1636-53 and KS 1731-260, we find that they match to a very good approximation, thus interpreting them as strange stars.Comment: 5 pages including 1 figure; Accepted for publication in ApJLet

Restrictions on the Physical Prescription for the Viscosity in Advection-Dominated Accretion Disks

It has recently been demonstrated that the Shakura-Sunyaev prescription for the kinematic viscosity in an advection-dominated accretion disk yields physically reasonable solutions for the structure of the inflow close to the event horizon. In particular, no violations of relativistic causality occur at the horizon. This is somewhat surprising considering the diffusive nature of the angular momentum transport in the Shakura-Sunyaev scenario, and it is therefore natural to ask whether one can also obtain acceptable solutions for the disk structure based on the various alternative models for the viscosity that have been proposed, including the "deterministic" forms. In this paper we perform a rigorous asymptotic analysis of the structure of an advection-dominated accretion disk close to the event horizon of a nonrotating black hole based on three of the alternative prescriptions for the viscosity that have been suggested in the literature. We constrain the physical disk model by stipulating that the stress must vanish at the horizon, which is the fundamental inner boundary condition imposed by general relativity. Surprisingly, we find that none of the three alternative viscosity prescriptions yield physically acceptable disk structures close to the horizon when the zero-torque condition is applied, whether the flow is in vertical hydrostatic equilibrium or free-fall. Hence we conclude that the original Shakura-Sunyaev prescription is the only one proposed so far that is physically consistent close to the event horizon.Comment: accepted for publication in the Astrophysical Journa

MHD Shock Conditions for Accreting Plasma onto Kerr Black Holes - I

We extend the work by Appl and Camenzind (1988) for special relativistic magnetohydrodynamic (MHD) jets, to fully general relativistic studies of the standing shock formation for accreting MHD plasma in a rotating, stationary and axisymmetric black hole magnetosphere. All the postshock physical quantities are expressed in terms of the relativistic compression ratio, which can be obtained in terms of preshock quantities. Then, the downstream state of a shocked plasma is determined by the upstream state of the accreting plasma. In this paper sample solutions are presented for slow magnetosonic shocks for accreting flows in the equatorial plane. We find that some properties of the slow magnetosonic shock for the rotating magnetosphere can behave like a fast magnetosonic shock. In fact, it is confirmed that in the limit of weak gravity for the upstream non-rotating accretion plasma where the magnetic field lines are leading and rotating, our results are very similar to the fast magnetosonic shock solution by Appl and Camenzind (1988). However, we find that the situation becomes far more complicated due to the effects of strong gravity and rotation, such as the frame dragging-effects. We show the tendency that the large spin of the black hole makes the slow magnetosonic shock strong for the accretion solutions with the same energy-flux.Comment: 22 pages, 8 figures, accepted to Ap

Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis

Background: Hepatic dysfunction and jaundice are traditionally viewed as late features of sepsis and portend poor outcomes. We hypothesized that changes in liver function occur early in the onset of sepsis, yet pass undetected by standard laboratory tests. Methods and Findings: In a long-term rat model of faecal peritonitis, biotransformation and hepatobiliary transport were impaired, depending on subsequent disease severity, as early as 6 h after peritoneal contamination. Phosphatidylinositol-3-kinase (PI3K) signalling was simultaneously induced at this time point. At 15 h there was hepatocellular accumulation of bilirubin, bile acids, and xenobiotics, with disturbed bile acid conjugation and drug metabolism. Cholestasis was preceded by disruption of the bile acid and organic anion transport machinery at the canalicular pole. Inhibitors of PI3K partially prevented cytokine-induced loss of villi in cultured HepG2 cells. Notably, mice lacking the PI3Kγ gene were protected against cholestasis and impaired bile acid conjugation. This was partially confirmed by an increase in plasma bile acids (e.g., chenodeoxycholic acid [CDCA] and taurodeoxycholic acid [TDCA]) observed in 48 patients on the day severe sepsis was diagnosed; unlike bilirubin (area under the receiver-operating curve: 0.59), these bile acids predicted 28-d mortality with high sensitivity and specificity (area under the receiver-operating curve: CDCA: 0.77; TDCA: 0.72; CDCA+TDCA: 0.87). Conclusions: Liver dysfunction is an early and commonplace event in the rat model of sepsis studied here; PI3K signalling seems to play a crucial role. All aspects of hepatic biotransformation are affected, with severity relating to subsequent prognosis. Detected changes significantly precede conventional markers and are reflected by early alterations in plasma bile acids. These observations carry important implications for the diagnosis of liver dysfunction and pharmacotherapy in the critically ill. Further clinical work is necessary to extend these concepts into clinical practice. Please see later in the article for the Editors' Summary

Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

Inflammatory caspase sensing of cytosolic lipopolysaccharide (LPS) triggers pyroptosis and the concurrent release of damage-associated molecular patterns (DAMPs). Collectively, DAMPs are key determinants that shape the aftermath of inflammatory cell death. However, the identity and function of the individual DAMPs released are poorly defined. Our proteomics study revealed that cytosolic LPS sensing triggered the release of galectin-1, a β-galactoside-binding lectin. Galectin-1 release is a common feature of inflammatory cell death, including necroptosis. In vivo studies using galectin-1-deficient mice, recombinant galectin-1 and galectin-1-neutralizing antibody showed that galectin-1 promotes inflammation and plays a detrimental role in LPS-induced lethality. Mechanistically, galectin-1 inhibition of CD45 (Ptprc) underlies its unfavorable role in endotoxin shock. Finally, we found increased galectin-1 in sera from human patients with sepsis. Overall, we uncovered galectin-1 as a bona fide DAMP released as a consequence of cytosolic LPS sensing, identifying a new outcome of inflammatory cell death.Fil: Russo, Ashley J.. UConn Health School of Medicine; Estados UnidosFil: Vasudevan, Swathy O.. UConn Health School of Medicine; Estados UnidosFil: Mendez Huergo, Santiago Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Kumari, Puja. UConn Health School of Medicine; Estados UnidosFil: Menoret, Antoine. UConn Health School of Medicine; Estados UnidosFil: Duduskar, Shivalee. Jena University Hospital; AlemaniaFil: Wang, Chengliang. UConn Health School of Medicine; Estados UnidosFil: Pérez Sáez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Fettis, Margaret M.. University of Florida; Estados UnidosFil: Li, Chuan. UConn Health School of Medicine; Estados UnidosFil: Liu, Renjie. University of Florida; Estados UnidosFil: Wanchoo, Arun. University of Florida; Estados UnidosFil: Chandiran, Karthik. UConn Health School of Medicine; Estados UnidosFil: Ruan, Jianbin. UConn Health School of Medicine; Estados UnidosFil: Vanaja, Sivapriya Kailasan. UConn Health School of Medicine; Estados UnidosFil: Bauer, Michael. Jena University Hospital; AlemaniaFil: Sponholz, Christoph. Jena University Hospital; AlemaniaFil: Hudalla, Gregory A.. University of Florida; Estados UnidosFil: Vella, Anthony T.. UConn Health School of Medicine; Estados UnidosFil: Zhou, Beiyan. UConn Health School of Medicine; Estados UnidosFil: Deshmukh, Sachin D.. Jena University Hospital; AlemaniaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rathinam, Vijay A.. UConn Health School of Medicine; Estados Unido