7 research outputs found

    Prognostic significance and correlation to gene expression profile of EZH2 mutations in diffuse large B‐cell lymphoma (DLBL) in 2 large prospective studies

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    EZH2, a histone methyl transferase subunit of Polycomb repressor complex 2, is frequently mutated in DLBL. Inhibitors of EZH2 have demonstrated promising responses in early clinical trials. We examined the frequency of EZH2 mutation in 2 large prospective series of DLBL and correlated this to clinical outcomes in relation to other biological features
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