141 research outputs found

    Proverb interpretation in fluent aphasia and Alzheimer's disease: Implications beyond abstract thinking

    Get PDF
    This study compared proverb processing across three groups, i.e. patients with fluent aphasia (APH), patients with Alzheimer's Disease (AD), and normal control subjects (NC). Proverb stimuli were used to examine the effects of group membership and proverb familiarity in two presentation formats (i.e. spontaneous versus multiple-choice) on performance. The sensitivity of cognitive measures as predictors of ability to interpret proverbs was also investigated. In relation to NC subjects, patients with fluent APH exhibited significant difficulty formulating responses for familiar and unfamiliar spontaneous proverbs, whereas patients with AD demonstrated lower performance only on the unfamiliar proverbs. On the multiple-choice paradigm, however, patients with APH exhibited minimal difficulty. Conversely, the patients with AD manifested significant problems selecting the correct abstract response for familiar proverbs. With regard to predictors, language was relevant to familiar proverb interpretations and to proverbs presented in the spontaneous format. Cognition was a sensitive predictor for unfamiliar proverb interpretations and to the multiple-choice format. Deficits on the proverb tasks are discussed with reference to the potential breakdown of underlying linguistic and cognitive processes. The present data support the diagnostic value of proverbs in elucidating brain- behaviour relationships

    Off-fault deformation rate along the southern San Andreas Fault at Mecca Hills inferred from landscape modeling of curved drainages

    Get PDF
    Quantifying off-fault deformation (OFD) rates on geomorphic timescales (10^2-10^5 yr) along strike-slip faults is critical for resolving discrepancies between geologic and geodetic slip-rate estimates, improving knowledge of seismic hazard, and understanding the influence of tectonic motion on landscapes. Quantifying OFD over these timescales is challenging without displacement markers such as offset terraces or geologic contacts. We present a landscape evolution model coupled with distributed lateral tectonic shear to show how drainage basins sheared by lateral tectonic motion can reveal OFD rates. The model shows that OFD rate can control the orientation of drainage basin topography: the faster the OFD rate, the greater the deflection of drainage basins towards a fault-parallel orientation. We apply the model to the southern San Andreas Fault near the Mecca Hills, where drainages basins change in orientation with proximity to the fault. Comparison of observed and modeled topography suggests that the OFD rate in the Mecca Hills follows an exponential-like spatial pattern with a maximum rate nearest the fault of 3.5 ± 1.5 mm/yr, which decays to approximately zero at ~600 m distance from the fault. This rate is applicable since the initiation of differential rock uplift in the Mecca Hills at approximately 760 ka. Our results suggest that OFD in this 800 m study area may be as high as 10% of total plate motion. This example demonstrates that curved drainage basins may be used to estimate OFD rates along strike slip faults

    Subliminal versus supraliminal stimuli activate neural responses in anterior cingulate cortex, fusiform gyrus and insula:a meta-analysis of fMRI studies

    Get PDF
    Background: Non-conscious neural activation may underlie various psychological functions in health and disorder. However, the neural substrates of non-conscious processing have not been entirely elucidated. Examining the differential effects of arousing stimuli that are consciously, versus unconsciously perceived will improve our knowledge of neural circuitry involved in non-conscious perception. Here we conduct preliminary analyses of neural activation in studies that have used both subliminal and supraliminal presentation of the same stimulus. Methods: We use Activation Likelihood Estimation (ALE) to examine functional Magnetic Resonance Imaging (fMRI) studies that uniquely present the same stimuli subliminally and supraliminally to healthy participants during functional magnetic resonance imaging (fMRI). We included a total of 193 foci from 9 studies representing subliminal stimulation and 315 foci from 10 studies representing supraliminal stimulation. Results: The anterior cingulate cortex is significantly activated during both subliminal and supraliminal stimulus presentation. Subliminal stimuli are linked to significantly increased activation in the right fusiform gyrus and right insula. Supraliminal stimuli show significantly increased activation in the left rostral anterior cingulate. Conclusions: Non-conscious processing of arousing stimuli may involve primary visual areas and may also recruit the insula, a brain area involved in eventual interoceptive awareness. The anterior cingulate is perhaps a key brain region for the integration of conscious and non-conscious processing. These preliminary data provide candidate brain regions for further study in to the neural correlates of conscious experience

    Place preference induced by nucleus accumbens amphetamine is impaired by local blockade of Group II metabotropic glutamate receptors in rats

    Get PDF
    BACKGROUND: The nucleus accumbens (NAc) plays a critical role in amphetamine-produced conditioned place preference (CPP). In previous studies, NAc basal and amphetamine-produced DA transmission was altered by Group II mGluR agents. We tested whether NAc amphetamine CPP depends on Group II mGluR transmission. RESULTS: NAc injections (0.5 μl/side) of the Group II mGluR antagonist (2 S)- a-ethylglutamic acid (EGLU: 0.01–0.8 μg but not 0.001 μg) impaired CPP. The drug did not block the acute locomotor effect of amphetamine. CONCLUSION: Results suggest that Group II mGluRs may be necessary for the establishment of NAc amphetamine-produced CPP. These receptors may also mediate other forms of reward-related learning dependent on this structure

    Transforming growth factor β recruits persistent MAPK signaling to regulate long-term memory consolidation in Aplysia californica.

    No full text
    In this study, we explore the mechanistic relationship between growth factor signaling and kinase activity that supports the protein synthesis-dependent phase of long-term memory (LTM) consolidation for sensitization ofAplysia Specifically, we examine LTM for tail shock-induced sensitization of the tail-elicited siphon withdrawal (T-SW) reflex, a form of memory that requires both (i) extracellular signal-regulated kinase (ERK1/2; MAPK) activity within identified sensory neurons (SNs) that mediate the T-SW and (ii) the activation of transforming growth factor β (TGFβ) signaling. We now report that repeated tail shocks that induce intermediate-term (ITM) and LTM for sensitization, also induce a sustained post-training phase of MAPK activity in SNs (lasting at least 1 h). We identified two mechanistically distinct phases of post-training MAPK: (i) an immediate phase that does not require ongoing protein synthesis or TGFβ signaling, and (ii) a sustained phase that requires both protein synthesis and extracellular TGFβ signaling. We find that LTM consolidation requires sustained MAPK, and is disrupted by inhibitors of protein synthesis and TGFβ signaling during the consolidation window. These results provide strong evidence that TGFβ signaling sustains MAPK activity as an essential mechanistic step for LTM consolidation
    corecore