Detection of subthreshold pulses in neurons with channel noise

Neurons are subject to various kinds of noise. In addition to synaptic noise, the stochastic opening and closing of ion channels represents an intrinsic source of noise that affects the signal processing properties of the neuron. In this paper, we studied the response of a stochastic Hodgkin-Huxley neuron to transient input subthreshold pulses. It was found that the average response time decreases but variance increases as the amplitude of channel noise increases. In the case of single pulse detection, we show that channel noise enables one neuron to detect the subthreshold signals and an optimal membrane area (or channel noise intensity) exists for a single neuron to achieve optimal performance. However, the detection ability of a single neuron is limited by large errors. Here, we test a simple neuronal network that can enhance the pulse detecting abilities of neurons and find dozens of neurons can perfectly detect subthreshold pulses. The phenomenon of intrinsic stochastic resonance is also found both at the level of single neurons and at the level of networks. At the network level, the detection ability of networks can be optimized for the number of neurons comprising the network.Comment: 14 pages, 9 figure

The galaxy's 157 micron (C 2) emission: Observations by means of a spectroscopic lunar-occultation technique

Galactic (C II) 157 micron, fine-structure emission was estimated. At a Galactic longitude of 8 deg, the peak power observed in a 7' x 7' field is approx. 5 x 10 to the -9 Watt. The method used to detect this radiation involved chopping against the cold side of the Moon

Highly ejected J = 16 to 15 rotational transitions of CO at 162.8 mirons in the Orion cloud

The first observations of the J = 16 to J = 15, 162.8 microns transition of CO from an astronomical source are reported. Measurements were carried out on the Kleinmann-Low Nebula. The intensity observed is in good agreement with predictions from previous spectroscopic work carried out in the far infrared. The observation strengthens the previous claim that approximately 1.5 solar mass of molecular hydrogen is heated to a temperature above 750 K within the shocked region in the Nebula. Upper limits to he OH intensity in the F2 (2Pi 1/2) transitions J = 3/2 to J = 1/2 which fall into two groups centered respectively at 163.12 and 163.40 are presented

Observations of the 145.5 micron (OI) emission line in the Orion nebula

A first set of observations of the (OI) 3P to 3P1 (145.5 micron) transition was obtained. The line was observed both in a beam centered on the Trapezium, and in a 7 times wider beam encompassing most of the Orion Nebula. A wide beam map of the region was constructed which shows that most of the emission is confined to the central regions of the nebula. These observations may be compared with reported measurement of the 3P1 to 3P2 (63.2 micron) transition in Orion and are consistent with optically thin emission in the 145.5 micron line and self-adsorbed 63.2 micron emission lines. Mechanisms are discussed for the excitation of neutral oxygen. It is included that much of the observed emission originates in the thin, radio-recombination-line-emitting CII/HI envelope bordering on the HII region

Brain natriuretic peptide and NT-proBNP levels reflect pulmonary artery systolic pressure in trekkers at high altitude.

Our objective was to evaluate the utility of the natriuretic peptides BNP (brain natriuretic peptide) and NT-proBNP as markers of pulmonary artery systolic pressure (PASP) in trekkers ascending to high altitude (HA). 20 participants had BNP and NT-proBNP assayed and simultaneous echocardiographic assessment of PASP performed during a trek to 5150 m. PASP increased significantly (p=0.006) with ascent from 24+/-4 to 39+/-11 mm Hg at 5150 m. At 5150 m those with a PASP>/=40 mm Hg (n=8) (versus those with PASP/=400 pg/ml) rise in NT-proBNP at 5150 m (n=4) PASP was significantly higher: 45.9+/-7.5 vs. 32.2+/-6.2 mm Hg (p=0.015). BNP and NT-proBNP may reflect elevated PASP, a central feature of high altitude pulmonary oedema, at HA

The Energetics of Molecular Gas in NGC 891 from H_2 and Far-infrared Spectroscopy

We have studied the molecular hydrogen energetics of the edge-on spiral galaxy NGC 891, using a 34 position map in the lowest three pure rotational H_2 lines observed with the Spitzer Infrared Spectrograph. The S(0), S(1), and S(2) lines are bright with an extinction-corrected total luminosity of ~2.8 × 10^7 L_☉, or 0.09% of the total-infrared luminosity of NGC 891. The H_2 line ratios are nearly constant along the plane of the galaxy—we do not observe the previously reported strong drop-off in the S(1)/S(0) line intensity ratio in the outer regions of the galaxy, so we find no evidence for the very massive cold CO-free molecular clouds invoked to explain the past observations. The H_2 level excitation temperatures increase monotonically indicating that there is more than one component to the emitting gas. More than 99% of the mass is in the lowest excitation (T_(ex) ~ 125 K) "warm" component. In the inner galaxy, the warm H_2 emitting gas is ~16% of the CO(1-0)-traced cool molecular gas, while in the outer regions the fraction is twice as high. This large mass of warm gas is heated by a combination of the far-UV photons from stars in photodissociation regions (PDRs) and the dissipation of turbulent kinetic energy. Including the observed far-infrared [O I] and [C II] fine-structure line emission and far-infrared continuum emission in a self-consistent manner to constrain the PDR models, we find essentially all of the S(0) and most (70%) of the S(1) line arise from low excitation PDRs, while most (80%) of the S(2) and the remainder of the S(1) line emission arise from low-velocity microturbulent dissipation

Resolving Star Formation on Sub-Kiloparsec Scales in the High-Redshift Galaxy SDP.11 Using Gravitational Lensing

We investigate the properties of the interstellar medium, star formation, and the current-day stellar population in the strongly-lensed star-forming galaxy H-ATLAS J091043.1-000321 (SDP.11), at z = 1.7830, using new Herschel and ALMA observations of far-infrared fine-structure lines of carbon, oxygen and nitrogen. We report detections of the [O III] 52 um, [N III] 57 um, and [O I] 63 um lines from Herschel/PACS, and present high-resolution imaging of the [C II] 158 um line, and underlying continuum, using ALMA. We resolve the [C II] line emission into two spatially-offset Einstein rings, tracing the red- and blue-velocity components of the line, in the ALMA/Band-9 observations at 0.2" resolution. The values seen in the [C II]/FIR ratio map, as low as ~ 0.02% at the peak of the dust continuum, are similar to those of local ULIRGs, suggesting an intense starburst in this source. This is consistent with the high intrinsic FIR luminosity (~ 3 x 10^12 Lo), ~ 16 Myr gas depletion timescale, and < 8 Myr timescale since the last starburst episode, estimated from the hardness of the UV radiation field. By applying gravitational lensing models to the visibilities in the uv-plane, we find that the lensing magnification factor varies by a factor of two across SDP.11, affecting the observed line profiles. After correcting for the effects of differential lensing, a symmetric line profile is recovered, suggesting that the starburst present here may not be the result of a major merger, as is the case for local ULIRGs, but instead could be powered by star-formation activity spread across a 3-5 kpc rotating disk.Comment: 17 pages, 8 figures, 3 tables, accepted for publication in the Astrophysical Journa

Search for correlation effects in linear chains of trapped ions

We report a precise search for correlation effects in linear chains of 2 and 3 trapped Ca+ ions. Unexplained correlations in photon emission times within a linear chain of trapped ions have been reported, which, if genuine, cast doubt on the potential of an ion trap to realize quantum information processing. We observe quantum jumps from the metastable 3d 2D_{5/2} level for several hours, searching for correlations between the decay times of the different ions. We find no evidence for correlations: the number of quantum jumps with separations of less than 10 ms is consistent with statistics to within errors of 0.05%; the lifetime of the metastable level derived from the data is consistent with that derived from independent single-ion data at the level of the experimental errors 1%; and no rank correlations between the decay times were found with sensitivity to rank correlation coefficients at the level of |R| = 0.024.Comment: With changes to introduction. 5 pages, including 4 figures. Submitted to Europhys. Let